The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
MR Elastography of the Liver: Preliminary Results
Abstract
PURPOSE: To develop a method for measuring liver stiffness with magnetic resonance (MR) elastography and to prospectively test this technique in healthy volunteers and patients with liver fibrosis. MATERIALS AND METHODS: This HIPAA-compliant study was approved by an institutional review board, and informed consent was obtained from each subject. First, to determine the feasibility of applying shear waves to the liver, a pneumatic acoustic wave generator was developed and tested by using a tissue-simulating gel phantom with ribs on one side and without ribs on the other. The effect of interposed ribs on stiffness measurements was tested. Then, liver stiffness was measured with MR elastography in 12 healthy volunteers (eight men, four women; mean age, 26.7 years; age range, 19-39 years) by using the subcostal approach and the transcostal approach and in 12 patients with chronic liver disease (six men, six women; mean age, 50.5 years; age range, 36-60 years) by using the transcostal approach. Various statistical analyses were performed to assess all measurements. RESULTS: Ex vivo, interposed ribs reduced shear wave amplitude but did not hinder stiffness measurements. In volunteers, the transcostal approach surprisingly yielded better shear waves in the liver than did the subcostal approach. The mean liver shear stiffness was significantly lower in volunteers (mean, 2.0 kPa +/- 0.3 [standard deviation]) than it was in patients with liver fibrosis (mean, 5.6 kPa +/- 5.0; median, 3.7 kPa; range, 2.7-19.2 kPa; P < .001). CONCLUSION: MR elastography of the liver is feasible and shows promise as a quantitative method for noninvasive assessment of liver fibrosis.
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Histological grading and staging of chronic hepatitis
Ishak, K., Baptista, A., Bianchi, L., Callea, F., De Groote, J., Gudat, F., Denk, H., Desmet, V., Korb, G., MacSween, R. N. M., et al. (1995) · Journal of Hepatology · doi:10.1016/0168-8278(95)80226-6 · Cited by 5,029
Elastography: A quantitative method for imaging the elasticity of biological tissues
Ophir, J. (1991) · Ultrasonic Imaging · doi:10.1016/0161-7346(91)90079-w · Cited by 3,776
Natural history of liver fibrosis progression in patients with chronic hepatitis C
Poynard, T., Bedossa, P., & Opolon, P. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07642-8 · Cited by 3,011
Transient elastography: a new noninvasive method for assessment of hepatic fibrosis
Sandrin, L., Fourquet, B., Hasquenoph, J.-M., Yon, S., Fournier, C., Mal, F., Christidis, C., Ziol, M., Poulet, B., Kazemi, F., et al. (2003) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2003.07.001 · Cited by 2,738
Magnetic Resonance Elastography by Direct Visualization of Propagating Acoustic Strain Waves
Muthupillai, R., Lomas, D. J., Rossman, P. J., Greenleaf, J. F., Manduca, A., & Ehman, R. L. (1995) · Science · doi:10.1126/science.7569924 · Cited by 2,116
Self-citationBravo, A. A., Sheth, S. G., & Chopra, S. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102153440706 · Cited by 2,041
Bedossa, P. (1994) · Hepatology · doi:10.1002/hep.1840200104 · Cited by 2,003
Liver fibrosis – from bench to bedside
Friedman, S. L. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00429-4 · Cited by 1,780
Complications following percutaneous liver biopsy
Piccinino, F., Sagnelli, E., Pasquale, G., Giusti, G., Battocchia, A., Bernardi, M., Bertolazzi, R., Bianchi, F. B., Brunelli, E., Budillon, G., et al. (1986) · Journal of Hepatology · doi:10.1016/s0168-8278(86)80075-7 · Cited by 1,202
Magnetic resonance elastography: Non-invasive mapping of tissue elasticity
Manduca, A., Oliphant, T. E., Dresner, M. A., Mahowald, J. L., Kruse, S. A., Amromin, E., Felmlee, J. P., Greenleaf, J. F., & Ehman, R. L. (2001) · Medical Image Analysis · doi:10.1016/s1361-8415(00)00039-6 · Cited by 1,103
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Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting
Ma, X., Qu, X., Zhu, W., Li, Y.-S., Yuan, S., Zhang, H., Liu, J., Wang, P., Lai, C. S. E., Zanella, F., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524510113 · Cited by 872
Magnetic resonance elastography of liver: Technique, analysis, and clinical applications
Venkatesh, S. K., Yin, M., & Ehman, R. L. (2013) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.23731 · Cited by 659
Self-citationFriedrich-Rust, M., Wunder, K., Kriener, S., Sotoudeh, F., Richter, S., Bojunga, J., Herrmann, E., Poynard, T., Dietrich, C. F., Vermehren, J., et al. (2009) · Radiology · doi:10.1148/radiol.2523081928 · Cited by 620
Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis
Georges, P. C., Hui, J.-J., Gombos, Z., McCormick, M. E., Wang, A. Y., Uemura, M., Mick, R., Janmey, P. A., Furth, E. E., & Wells, R. G. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00032.2007 · Cited by 577
Liver stiffness: a novel parameter for the diagnosis of liver disease
Mueller, S. (2010) · Hepatic Medicine: Evidence and Research · doi:10.2147/hmer.s7394 · Cited by 434
Metadata
- Authors
- Rouvière, O., Yin, M., Dresner, M. A., Rossman, P. J., Burgart, L. J., Fidler, J. L., & Ehman, R. L.
- Venue
- Radiology
- Published
- 2006-08
- Volume
- 240
- Issue
- 2
- Pages
- 440-448
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2112348746
- Cited by
- 447
- References
- 31
- FWCI
- 22.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rouvière, O., Yin, M., Dresner, M. A., Rossman, P. J., Burgart, L. J., Fidler, J. L., & Ehman, R. L. (2006). MR Elastography of the Liver: Preliminary Results. Radiology. https://doi.org/10.1148/radiol.2402050606
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