The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting
Open accessAbstract
Significance: The great challenge to developing an in vitro liver model lies in the limitation of current approaches to recapitulate the sophisticated liver microenvironment contributed by the complex microarchitecture and diverse cell combination. We demonstrate an innovative advancement toward simulating natural complexity by integrating a rapid 3D bioprinting technology with tissue engineering to develop a microscale hepatic construct consisting of physiologically relevant hexagonal units of liver cells and supporting cells. The entire construct is fabricated within several seconds on minimal UV illumination. The model enables the structural and functional improvements of human induced pluripotent stem cell-derived hepatic progenitor cells and therefore can be used in early personalized drug screening and liver pathophysiology studies in vitro.
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Cites
Cell-laden microengineered gelatin methacrylate hydrogels
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Vascularized and functional human liver from an iPSC-derived organ bud transplant
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Geometric control of vascular networks to enhance engineered tissue integration and function
Baranski, J. D., Chaturvedi, R. R., Stevens, K. R., Eyckmans, J., Carvalho, B., Solorzano, R. D., Yang, M. T., Miller, J. S., Bhatia, S. N., & Chen, C. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217796110 · Cited by 267
HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells
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Cited by
Advances in engineering hydrogels
Zhang, Y. S., & Khademhosseini, A. (2017) · Science · doi:10.1126/science.aaf3627 · Cited by 2,908
3D bioprinting of collagen to rebuild components of the human heart
Lee, A., Hudson, A. R., Shiwarski, D. J., Tashman, J. W., Hinton, T. J., Yerneni, S., Bliley, J. M., Campbell, P. G., & Feinberg, A. W. (2019) · Science · doi:10.1126/science.aav9051 · Cited by 1,782
3D printing of functional biomaterials for tissue engineering
Zhu, W., Ma, X., Gou, M., Mei, D., Zhang, K., & Chen, S. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.03.014 · Cited by 822
Self-citationBioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs
Ashammakhi, N., Ahadian, S., Xu, C., Montazerian, H., Ko, H., Nasiri, R., Barros, N., & Khademhosseini, A. (2019) · Materials Today Bio · doi:10.1016/j.mtbio.2019.100008 · Cited by 549
Unagolla, J. M., & Jayasuriya, A. C. (2020) · Applied Materials Today · doi:10.1016/j.apmt.2019.100479 · Cited by 544
Metadata
- Authors
- Ma, X., Qu, X., Zhu, W., Li, Y.-S., Yuan, S., Zhang, H., Liu, J., Wang, P., Lai, C. S. E., Zanella, F., Feng, G.-S., Sheikh, F., Chien, S., & Chen, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-02-08
- Volume
- 113
- Issue
- 8
- Pages
- 2206-2211
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2264718512
- Cited by
- 872
- References
- 9
- FWCI
- 38.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Ma, X., Qu, X., Zhu, W., Li, Y.-S., Yuan, S., Zhang, H., Liu, J., Wang, P., Lai, C. S. E., Zanella, F., Feng, G.-S., Sheikh, F., Chien, S., & Chen, S. (2016). Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1524510113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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