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Cited by 323

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Idiopathic Pulmonary Fibrosis: Physiologic Tests, Quantitative CT Indexes, and CT Visual Scores as Predictors of Mortality

Best, Alan C., Meng, Jiangfeng, Lynch, Anne M., Bozic, Carmen M., Miller, David, Grunwald, Gary K., Lynch, David A.·2008·Radiology
DOI 10.1148/radiol.2463062200
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Abstract

PURPOSE: To retrospectively evaluate quantitative computed tomographic (CT) indexes, pulmonary function test results, and visual CT scoring as predictors of mortality and to describe serial changes in quantitative CT indexes over 12 months in patients with idiopathic pulmonary fibrosis (IPF). MATERIALS AND METHODS: Institutional review board approval and informed consent were obtained at all participating institutions. One hundred sixty-seven patients (110 men, 57 women; mean age, 63 years +/- 9 [standard deviation]) with IPF were enrolled in a clinical trial. Patients underwent thin-section CT in the supine position at full inspiration at enrollment (baseline) and at 12-month follow-up. After segmentation of the lungs, mean lung attenuation (MLA), skewness, and kurtosis were measured. Extent of ground glass opacity and lung fibrosis were assessed visually. Forced vital capacity (FVC) and total lung capacity (TLC) were measured. Median duration of follow-up for mortality was 1.5 years. Univariate and multivariate survival analyses were used to determine the predictive value of baseline variables for survival. RESULTS: At univariate analysis, baseline variables predictive of death included TLC, fibrosis, skewness, and kurtosis. At multivariate analysis, FVC (P = .006) and fibrosis (P = .002) were predictors of short-term mortality. In 95 patients who had both baseline and follow-up CT scans, fibrosis (P = .030), MLA (P = .003), skewness (P < .001), and kurtosis (P < .001) all showed change indicating disease progression. CONCLUSION: Visually determined disease extent on CT images is a strong independent predictor of mortality in IPF. Serial evaluation of quantitative CT measures can show disease progression in these patients.

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Metadata

Authors
Best, A. C., Meng, J., Lynch, A. M., Bozic, C. M., Miller, D., Grunwald, G. K., & Lynch, D. A.
Venue
Radiology
Publisher
Radiological Society of North America (RSNA)
Published
2008-03
Volume
246
Issue
3
Pages
935-940
ISSN
  • 0033-8419 (ISSN-L)
  • 1527-1315
DOI
10.1148/radiol.2463062200
OpenAlex
W2155709621
Cited by
323
References
19
FWCI
10.30
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Idiopathic Pulmonary Fibrosis: Physiologic Tests, Quantitative CT Indexes, and CT Visual Scores as Predictors of Mortality. https://app.cochat.ai/papers/10.1148/radiol.2463062200
The paper
Best, A. C., Meng, J., Lynch, A. M., Bozic, C. M., Miller, D., Grunwald, G. K., & Lynch, D. A. (2008). Idiopathic Pulmonary Fibrosis: Physiologic Tests, Quantitative CT Indexes, and CT Visual Scores as Predictors of Mortality. Radiology. https://doi.org/10.1148/radiol.2463062200

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.