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Multiple sclerosis: gadolinium enhancement in MR imaging.
Abstract
Magnetic resonance (MR) images--both nonenhanced and enhanced with gadolinium DTPA/dimeglumine (Gd)--were compared with high-iodine (88.1 g I) computed tomographic (HICT) scans in demonstrating lesions in 15 patients known to have multiple sclerosis (MS). T1-weighted, mixed (T1, proton density, and T2), and T2-weighted MR pulse sequences were used. More than 20 lesions in each of 14 patients were demonstrated by pre-Gd mixed images and T2WI. Nine patients had clinical symptoms of active disease. Gd-enhanced T1WI showed at least one lesion that appeared to correspond with newly reported symptoms or signs. In addition, three clinically stable patients showed enhancement. Enhancement was best seen on 3-minute T1WI. HICT scans showed enhancement in four of the nine patients with active disease and in none of five clinically stable patients. Gd-enhanced MR imaging appears to be more sensitive than HICT in the detection of the transient abnormalities of the blood-brain barrier that occur in patients with active MS and appears capable of distinguishing active lesions that may correspond to the anatomic regions responsible for abnormal clinical findings.
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Cited by
Tofts, P. S., & Kermode, A. G. (1991) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910170208 · Cited by 1,456
Barkhof, F. (1997) · Brain · doi:10.1093/brain/120.11.2059 · Cited by 1,251
KERMODE, A. G., THOMPSON, A. J., TOFTS, P., MACMANUS, D. G., KENDALL, B. E., KINGSLEY, D. P. E., MOSELEY, I. F., RUDGE, P., & MCDONALD, W. I. (1990) · Brain · doi:10.1093/brain/113.5.1477 · Cited by 578
Kappos, L., Moeri, D., Radue, E. W., Schoetzau, A., Schweikert, K., Barkhof, F., Miller, D., Guttmann, C. R., Weiner, H. L., Gasperini, C., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)03053-0 · Cited by 499
Katz, D., Taubenberger, J. K., Cannella, B., McFarlin, D. E., Raine, C. S., & McFarland, H. F. (1993) · Annals of Neurology · doi:10.1002/ana.410340507 · Cited by 387
Metadata
- Authors
- Grossman, R. I., Gonzalez-Scarano, F., Atlas, S. W., Galetta, S., & Silberberg, D. H.
- Venue
- Radiology
- Published
- 1986-12
- Volume
- 161
- Issue
- 3
- Pages
- 721-725
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2131387237
- Cited by
- 289
- References
- 0
- FWCI
- 10.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Grossman, R. I., Gonzalez-Scarano, F., Atlas, S. W., Galetta, S., & Silberberg, D. H. (1986). Multiple sclerosis: gadolinium enhancement in MR imaging. Radiology. https://doi.org/10.1148/radiology.161.3.3786722
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