Human brain: Proton diffusion MR spectroscopy
Abstract
Diffusion of brain metabolites was measured in 10 healthy volunteers by using localized proton diffusion magnetic resonance (MR) spectroscopy. Measurements were conducted with a clinical MR imager by using a stimulated-echo pulse sequence (3,000/60 [repetition time msec/echo time msec], 200-msec mixing time) with additional outside-volume suppression. Motion artifacts due to macroscopic brain movements were compensated by means of peripheral cardiac gating and separate collection of individual spectroscopic acquisitions into a two-dimensional data matrix. Phase errors due to macroscopic motion were subsequently corrected in individual data traces prior to spectral averaging. Mean (+/- 1 standard deviation) apparent diffusion coefficients of choline-containing compounds ([0.13 +/- 0.03] x 10(-3) mm2/sec), creatine and phosphocreatine ([0.15 +/- 0.03] x 10(-3) mm2/sec), and N-acetyl aspartate ([0.18 +/- 0.02] x 10(-3) mm2/sec) were substantially smaller than that of water and were consistent with recently published data obtained in anesthetized and paralyzed animals. Adequate diffusion sensitivity for metabolites in the human brain can be obtained with clinical whole-body imagers despite macroscopic head and brain movements.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Diffusion MRI has been used to investigate the diffusion of nonwater molecules in the human brain, notably metabolites and neurotransmitters.
“Diffusion MRI has also been used to investigate the diffusion of nonwater molecules in the human brain, notably metabolites and neurotransmitters (Posse et al., 1993).”
From 40 Years of diffusion MRI in the brain: From history to emerging frontiers (2026) · cites this paper as Posse et al., 1993
Cites
Spin Diffusion Measurements: Spin Echoes in the Presence of a Time-Dependent Field Gradient
Stejskal, E. O., & Tanner, J. E. (1965) · The Journal of Chemical Physics · doi:10.1063/1.1695690 · Cited by 8,239 · see citing works
Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging.
Bihan, D. L., Breton, E., Lallemand, D. P., Aubin, M., Vignaud, J., & Laval-Jeantet, M. (1988) · Radiology · doi:10.1148/radiology.168.2.3393671 · Cited by 3,174 · see citing works
Self-diffusion in normal and heavy water in the range 1-45.deg.
Mills, R. (1973) · The Journal of Physical Chemistry · doi:10.1021/j100624a025 · Cited by 1,726 · see citing works
Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system.
Moseley, M. E., Cohen, Y., Kucharczyk, J. R., Mintorovitch, J., Asgari, H. S., Wendland, M. F., Tsuruda, J. S., & Norman, D. M. (1990) · Radiology · doi:10.1148/radiology.176.2.2367658 · Cited by 1,132 · see citing works
1H NMR chemical shift selective (CHESS) imaging
Haase, A., Frahm, J., Hänicke, W., & Matthaei, D. (1985) · Physics in Medicine and Biology · doi:10.1088/0031-9155/30/4/008 · Cited by 1,062 · see citing works
Moseley, M. E., Kucharczyk, J. R., Mintorovitch, J., Cohen, Y., Kurhanewicz, J. V., Derugin, N., Asgari, H. S., & Norman, D. M. (2024) · American Journal of Neuroradiology · doi:10.3174/ajnr.45-12.s8 · Cited by 890 · see citing works
Fast magnetic resonance diffusion-weighted imaging of acute human stroke
Warach, S., Chien, D., Li, W., Ronthal, M., & Edelman, R. R. (1992) · Neurology · doi:10.1212/wnl.42.9.1717 · Cited by 881 · see citing works
Localized proton spectroscopy using stimulated echoes
Frahm, J., Merboldt, K., & Hänicke, W. (1987) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(87)90154-5 · Cited by 837 · see citing works
Frahm, J., Bruhn, H., Gyngell, M. L., Merboldt, K. D., Hänicke, W., & Sauter, R. (1989) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910110105 · Cited by 522 · see citing works
Anisotropic diffusion in human white matter: demonstration with MR techniques in vivo.
Chenevert, T. L., Brunberg, J. A., & Pipe, J. G. (1990) · Radiology · doi:10.1148/radiology.177.2.2217776 · Cited by 503 · see citing works
Molecular diffusion nuclear magnetic resonance imaging.
Bihan, D. L. (1991) · PubMed · Cited by 438 · see citing works
Human brain motion and cerebrospinal fluid circulation demonstrated with MR velocity imaging.
Feinberg, D. A., & Mark, A. S. (1987) · Radiology · doi:10.1148/radiology.163.3.3575734 · Cited by 378 · see citing works
Brain parenchyma motion: measurement with cine echo-planar MR imaging.
Poncelet, B. P., Wedeen, V. J., Weisskoff, R. M., & Cohen, M. S. (1992) · Radiology · doi:10.1148/radiology.185.3.1438740 · Cited by 285 · see citing works
Brain motion: measurement with phase-contrast MR imaging.
Enzmann, D. R., & Pelc, N. J. (1992) · Radiology · doi:10.1148/radiology.185.3.1438741 · Cited by 275 · see citing works
van Zijl, P. C. M., MOONEN, C. T. W., Faustino, P., Pekar, J. J., Kaplan, O., & Cohen, J. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3228 · Cited by 220 · see citing works
Comparison of single‐shot localization methods (steam and press) for In vivo proton NMR spectroscopy
MOONEN, C. T. W., von Kienlin, M., van Zijl, P. C. M., Cohen, J. S., Gillen, J., Daly, P. F., & Wolf, G. L. (1989) · NMR in Biomedicine · doi:10.1002/nbm.1940020506 · Cited by 215 · see citing works
Volume-selective multipulse spin-echo spectroscopy
Kimmich, R., & Hoepfel, D. (1987) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(87)90304-0 · Cited by 192 · see citing works
Granot, J. (1986) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(86)90142-3 · Cited by 148 · see citing works
Highly Effective Water Suppression for in vivo proton NMR Spectroscopy (DRYSTEAM)
MOONEN, C. T. W., & van Zijl, P. C. M. (1990) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(90)90106-j · Cited by 140 · see citing works
Effects of susceptibility variations on NMR measurements of diffusion
Zhong, J., Kennan, R. P., & Gore, J. C. (1991) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(91)90217-h · Cited by 125 · see citing works
In vivo magnetic resonance imaging and spectroscopy of humans with a 4 t whole‐body magnet
Barfuss, H., Fischer, H., Hentschel, D., Ladebeck, R., Oppelt, A., Wittig, R., Duerr, W., & Oppelt, R. (1990) · NMR in Biomedicine · doi:10.1002/nbm.1940030106 · Cited by 119 · see citing works
Short Echo Time Proton MR Spectroscopic Imaging
Posse, S., Schuknecht, B., Smith, M. E., van Zijl, P. C. M., HERSCHKOWITZ, N. N., & MOONEN, C. T. W. (1993) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199301000-00001 · Cited by 97 · see citing works
Self-citationMR Imaging of Anisotropically Restricted Diffusion in the Brain of Neonates and Infants
Rutherford, M., Cowan, F. M., Manzur, A. Y., Dubowitz, L. M. S., Pennock, J. M., Hajnal, J. V., YOUNG, I. R., & Bydder, G. M. (1991) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199103000-00002 · Cited by 87 · see citing works
Merboldt, K., Hörstermann, D., Hänicke, W., Bruhn, H., & Frahm, J. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910290123 · Cited by 69 · see citing works
Motion Artifact Compensation in 1H Spectroscopic Imaging by Signal Tracking
Posse, S., Cuénod, C. A., & Bihan, D. L. (1993) · Journal of Magnetic Resonance Series B · doi:10.1006/jmrb.1993.1088 · Cited by 33 · see citing works
Self-citationThe human brain: localized H-1 MR spectroscopy at 1.0 T.
Sauter, R., Loeffler, W., Bruhn, H., & Frahm, J. (1990) · Radiology · doi:10.1148/radiology.176.1.2353095 · Cited by 26 · see citing works
Klammler, F., & Kimmich, R. (1990) · Physics in Medicine and Biology · doi:10.1088/0031-9155/35/1/007 · Cited by 19 · see citing works
Motion rephasing in gradient-localized spectroscopy
Gyngell, M. L., Frahm, J., Merboldt, K. D., Hänicke, W., & Bruhn, H. (1988) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(88)90020-0 · Cited by 11 · see citing works
4780674 Process for imaging by nuclear magnetic resonance
Breton, E., & Bihan, D. L. (1990) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(90)90230-y · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Looking into the functional architecture of the brain with diffusion MRI.
Le Bihan, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1119 · Cited by 1,571 · see citing works
Punwani, S., Ordidge, R. J., Cooper, C. E., Amess, P., & Clemence, M. (1998) · NMR in Biomedicine · doi:10.1002/(sici)1099-1492(199810)11:6 · Cited by 74 · see citing works
Magnetic Resonance Imaging of Acute Stroke
Baird, A. E., & Warach, S. J. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199806000-00001 · Cited by 542 · see citing works
Molecular diffusion, tissue microdynamics and microstructure
Bihan, D. L. (1995) · NMR in Biomedicine · doi:10.1002/nbm.1940080711 · Cited by 497 · see citing works
The Biological Basis of Diffusion Anisotropy
Beaulieu, C. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374709-9.00006-7 · Cited by 231 · see citing works
Assaf, Y., & Cohen, Y. (1998) · Journal of Magnetic Resonance · doi:10.1006/jmre.1997.1313 · Cited by 222 · see citing works
Liu, B., Gao, S., & Li, S. (2017) · Gynecologic and Obstetric Investigation · doi:10.1159/000456006 · Cited by 213 · see citing works
Diffusion tensor magnetic resonance imaging tractography in cognitive disorders
Catani, M. (2006) · Current Opinion in Neurology · doi:10.1097/01.wco.0000247610.44106.3f · Cited by 202 · see citing works
Jones, D. K., Alexander, D. C., Bowtell, R. W., Cercignani, M., Dell’Acqua, F., McHugh, D. J., Miller, K. L., Palombo, M., Parker, G. J. M., Rudrapatna, U. S., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.05.047 · Cited by 179 · see citing works
Nicolay, K., Braun, K. P. J., de Graaf, R. A., Dijkhuizen, R. M., & Kruiskamp, M. J. (2001) · NMR in Biomedicine · doi:10.1002/nbm.686 · Cited by 184 · see citing works
On the nature of the NAA diffusion attenuated MR signal in the central nervous system
Kroenke, C. D., Ackerman, J. J. H., & Yablonskiy, D. A. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20260 · Cited by 162 · see citing works
Diffusion tensor spectroscopy (DTS) of human brain
Ellegood, J., Hanstock, C. C., & Beaulieu, C. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20777 · Cited by 161 · see citing works
Pfeuffer, J., Tkáč, I., & Rolf Gruetter, A. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200004000-00011 · Cited by 151 · see citing works
SPLICE: Sub‐second diffusion‐sensitive MR imaging using a modified fast spin‐echo acquisition mode
Schick, F. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910380418 · Cited by 130 · see citing works
Diffusion of metabolites in normal and ischemic rat brain measured by localized 1H MRS
van der Toorn, A., Dijkhuizen, R. M., Tulleken, C. A. F., & Nicolay, K. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910360614 · Cited by 131 · see citing works
Posse, S., Dager, S. R., Richards, T. L., Yuan, C., Ogg, R. J., Artru, A. A., Müller‐Gärtner, H., & Hayes, C. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910370609 · Cited by 116 · see citing works
Self-citationAssaf, Y., & Cohen, Y. (1999) · NMR in Biomedicine · doi:10.1002/(sici)1099-1492(199910)12:6 · Cited by 101 · see citing works
Ronen, I., Budde, M. D., Ercan, E., Annese, J., Techawiboonwong, A., & WEBB, A. G. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0600-0 · Cited by 96 · see citing works
Madi, S., Hasan, K. M., & Narayana, P. A. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20304 · Cited by 95 · see citing works
T2 measurement of J‐coupled metabolites in the human brain at 3T
Ganji, S., Banerjee, A., Patel, A. M., Zhao, Y. D., Dimitrov, I. E., Browning, J. D., Brown, E. S., Maher, E. A., & Choi, C. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1767 · Cited by 86 · see citing works
Insights into brain microstructure from in vivo DW-MRS
Palombo, M., Shemesh, N., Ronen, I., & Valette, J. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.11.028 · Cited by 81 · see citing works
Anomalous Transverse Relaxation in 1H Spectroscopy in Human Brain at 4 Tesla
Posse, S., Cuénod, C. A., Risinger, R. C., Bihan, D. L., & Balaban, R. S. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330215 · Cited by 80 · see citing works
Self-citationDiffusion tensor spectroscopy and imaging of the arcuate fasciculus
Upadhyay, J., Hallock, K., Ducros, M. G., Kim, D., & Ronen, I. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.08.046 · Cited by 71 · see citing works
Investigating Axonal Damage in Multiple Sclerosis by Diffusion Tensor Spectroscopy
Wood, E. T., Ronen, I., Techawiboonwong, A., Jones, C. K., Barker, P. B., van Zijl, P. C. M., Harrison, D. M., & Reich, D. S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0044-12.2012 · Cited by 70 · see citing works
Assaf, Y., & Cohen, Y. (1998) · NMR in Biomedicine · doi:10.1002/(sici)1099-1492(199804)11:2 · Cited by 67 · see citing works
The Biological Basis of Diffusion Anisotropy
Beaulieu, C. (2014) · Diffusion MRI · doi:10.1016/b978-0-12-396460-1.00008-1 · Cited by 66 · see citing works
Diffusion‐weighted in vivo localized proton MR spectroscopy of human cerebral ischemia and tumor
Harada, M., 宇野, 昌., Hong, F., Hisaoka, S., Nishitani, H., & Matsuda, T. (2002) · NMR in Biomedicine · doi:10.1002/nbm.759 · Cited by 65 · see citing works
Diffusion-Weighted Magnetic Resonance Spectroscopy
Ronen, I., & Valette, J. (2015) · Wiley eBooks · doi:10.1002/9780470034590.emrstm1471 · Cited by 61 · see citing works
Najac, C., Branzoli, F., Ronen, I., & Valette, J. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0968-5 · Cited by 60 · see citing works
MR properties of rat sciatic nerve following trauma
Stanisz, G. J., Midha, R., Munro, C. A., & Henkelman, R. M. (2001) · Magnetic Resonance in Medicine · doi:10.1002/1522-2594(200103)45:3 · Cited by 95 · see citing works
Marchadour, C., Brouillet, E., Hantraye, P., Lebon, V., & Valette, J. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.119 · Cited by 58 · see citing works
Ackerman, J. J. H., & Neil, J. J. (2010) · NMR in Biomedicine · doi:10.1002/nbm.1530 · Cited by 58 · see citing works
Kan, H. E., Techawiboonwong, A., van Osch, M. J. P., Versluis, M. J., Deelchand, D. K., Henry, P., Marjańska, M., van Buchem, M. A., WEBB, A. G., & Ronen, I. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.23129 · Cited by 55 · see citing works
Ellegood, J., Hanstock, C. C., & Beaulieu, C. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20427 · Cited by 51 · see citing works
Single‐shot diffusion trace 1H NMR spectroscopy
de Graaf, R. A., Braun, K. P. J., & Nicolay, K. (2001) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1101 · Cited by 51 · see citing works
Felblinger, J., Kreis, R., & Boesch, C. (1998) · NMR in Biomedicine · doi:10.1002/(sici)1099-1492(199805)11:3 · Cited by 50 · see citing works
Valette, J., Guillermier, M., Besret, L., Hantraye, P., Bloch, G., & Lebon, V. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600353 · Cited by 47 · see citing works
In vivo diffusion spectroscopy. An overview
Nicolay, K., van der Toorn, A., & Dijkhuizen, R. M. (1995) · NMR in Biomedicine · doi:10.1002/nbm.1940080710 · Cited by 47 · see citing works
Bhattacharyya, P. K., Lowe, M. J., & Phillips, M. D. (2007) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21337 · Cited by 42 · see citing works
Diffusion characteristics of large molecules assessed by proton MRS on a whole-body MR system
Lehnert, A., Machann, J., Helms, G., Claussen, C. D., & Schick, F. (2004) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2003.05.007 · Cited by 42 · see citing works
Diffusion properties of NAA in human corpus callosum as studied with diffusion tensor spectroscopy
Upadhyay, J., Hallock, K., Erb, K., Kim, D., & Ronen, I. (2007) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21372 · Cited by 41 · see citing works
Dietrich, O., Heiland, S., Benner, T., & Sartor, K. J. (2000) · Neuroradiology · doi:10.1007/s002340050020 · Cited by 40 · see citing works
Advanced MRI in Multiple Sclerosis: Current Status and Future Challenges
Fox, R. J., Beall, E. B., Bhattacharyya, P. K., Chen, J. T., & Sakaie, K. (2011) · Neurologic Clinics · doi:10.1016/j.ncl.2010.12.011 · Cited by 38 · see citing works
Molecular aspects of magnetic resonance imaging and spectroscopy
Boesch, C. (1999) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(99)00007-2 · Cited by 38 · see citing works
Pattany, P. M., Khamis, I. H., Bowen, B. C., Goodkin, K., Weaver, R. G., Murdoch, J. B., Post, M. J. D., & Quencer, R. M. (2002) · PubMed Central · Cited by 38 · see citing works
Valette, J., Giraudeau, C., Marchadour, C., Djemaï, B., Geffroy, F., Ghaly, M. A., Bihan, D. L., Hantraye, P., Lebon, V., & Lethimonnier, F. (2012) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24193 · Cited by 35 · see citing works
Najac, C., Marchadour, C., Guillermier, M., Houitte, D., SLAVOV, V., Brouillet, E., Hantraye, P., Lebon, V., & Valette, J. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.12.045 · Cited by 35 · see citing works
Diffusion Spectroscopy in Living Systems
van Zijl, P. C. M., Davis, D., & MOONEN, C. T. W. (1994) · Elsevier eBooks · doi:10.1016/b978-0-12-283980-1.50016-8 · Cited by 35 · see citing works
In vivo diffusion MRS investigation of non‐water molecules in biological tissues
Cao, P., & Wu, E. X. (2016) · NMR in Biomedicine · doi:10.1002/nbm.3481 · Cited by 34 · see citing works
Single‐shot magnetic resonance spectroscopic imaging with partial parallel imaging
Posse, S., Otazo, R., Tsai, S., Yoshimoto, A. E., & Lin, F. (2008) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21855 · Cited by 34 · see citing works
Self-citationQuantitative diffusion imaging of adipose tissue in the human lower leg at 1.5 T
Steidle, G., Eibofner, F., & Schick, F. (2010) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22699 · Cited by 32 · see citing works
Valette, J., Ligneul, C., Marchadour, C., Najac, C., & Palombo, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00002 · Cited by 29 · see citing works
Ligneul, C., Najac, C., Döring, A., Beaulieu, C., Branzoli, F., Clarke, W. T., Cudalbu, C., Genovese, G., Jbabdi, S., Jelescu, I., et al. (2023) · Magnetic Resonance in Medicine · doi:10.1002/mrm.29877 · Cited by 32 · see citing works
Self-citationZheng, D. D., Liu, Z., Fang, J., Wang, X. Y., & Zhang, J. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2793 · Cited by 29 · see citing works
Döring, A., Adalid, V., Boesch, C., & Kreis, R. (2018) · Magnetic Resonance in Medicine · doi:10.1002/mrm.27222 · Cited by 28 · see citing works
Landheer, K., Gajdošík, M., & Juchem, C. (2020) · NMR in Biomedicine · doi:10.1002/nbm.4324 · Cited by 28 · see citing works
Diffusion‐weighted chemical shift imaging of human brain metabolites at 7T
Ercan, E., Techawiboonwong, A., Versluis, M. J., WEBB, A. G., & Ronen, I. (2014) · Magnetic Resonance in Medicine · doi:10.1002/mrm.25346 · Cited by 27 · see citing works
Pérez, Y., Lahrech, H., Cabañas, M. E., Barnadas‐Rodríguez, R., Sabés, M., Remy, C. C., & Arús, C. (2002) · PubMed · Cited by 27 · see citing works
Branzoli, F., Ercan, E., Valabrègue, R., Wood, E. T., Buijs, M., WEBB, A. G., & Ronen, I. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.07.022 · Cited by 27 · see citing works
Studying neurons and glia non-invasively via anomalous subdiffusion of intracellular metabolites
Ingo, C., Brink, W. M., Ercan, E., WEBB, A. G., & Ronen, I. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1719-9 · Cited by 27 · see citing works
Theoretical description of modern1H in Vivo magnetic resonance spectroscopic pulse sequences
Landheer, K., Schulte, R. F., Treacy, M., Swanberg, K. M., & Juchem, C. (2019) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.26846 · Cited by 27 · see citing works
Looking into the functional architecture of the brain with diffusion MRI
Bihan, D. L. (2006) · International Congress Series · doi:10.1016/j.ics.2006.04.006 · Cited by 28 · see citing works
Deelchand, D. K., Auerbach, E. J., & Marjańska, M. (2017) · Magnetic Resonance in Medicine · doi:10.1002/mrm.26969 · Cited by 26 · see citing works
Genovese, G., Marjańska, M., Auerbach, E. J., Yahia‐Cherif, L., Ronen, I., Lehéricy, S., & Branzoli, F. (2020) · NMR in Biomedicine · doi:10.1002/nbm.4206 · Cited by 23 · see citing works
Park, J. C., Wicki, J., Knoblaugh, S. E., Chamberlain, J. S., & Lee, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124914 · Cited by 25 · see citing works
Reischauer, C., Gutzeit, A., Neuwirth, C., Fuchs, A., Sartoretti‐Schefer, S., Weber, M., & Czell, D. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.10.001 · Cited by 25 · see citing works
Quantitative1H MRI and MRS Microscopy of Individual V79 Lung Tumor Spheroids
Minard, K. R., Guo, X., & Wind, R. A. (1998) · Journal of Magnetic Resonance · doi:10.1006/jmre.1998.1493 · Cited by 25 · see citing works
Liu, Z., Zheng, D., Wang, X., Zhang, J., Xie, S., Xiao, J., & Jiang, X.-X. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2395 · Cited by 24 · see citing works
Ellegood, J., Hanstock, C. C., & Beaulieu, C. (2010) · NMR in Biomedicine · doi:10.1002/nbm.1586 · Cited by 24 · see citing works
Wood, E. T., Ercan, E., Branzoli, F., WEBB, A. G., Sati, P., Reich, D. S., & Ronen, I. (2015) · NMR in Biomedicine · doi:10.1002/nbm.3340 · Cited by 22 · see citing works
Branzoli, F., Ercan, E., WEBB, A. G., & Ronen, I. (2014) · NMR in Biomedicine · doi:10.1002/nbm.3085 · Cited by 22 · see citing works
Wang, Y., & Wang, M. (2020) · Physica Medica · doi:10.1016/j.ejmp.2020.10.013 · Cited by 22 · see citing works
Kroenke, C. D., Ackerman, J. J. H., & Neil, J. J. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10579 · Cited by 22 · see citing works
From Brownian motion to virtual biopsy: a historical perspective from 40 years of diffusion MRI
Bihan, D. L. (2024) · Japanese Journal of Radiology · doi:10.1007/s11604-024-01642-z · Cited by 21 · see citing works
Valette, J., Guillermier, M., Besret, L., Boumezbeur, F., Hantraye, P., & Lebon, V. (2005) · NMR in Biomedicine · doi:10.1002/nbm.985 · Cited by 21 · see citing works
Frame‐by‐frame PRESS 1H‐MRS of the brain at 3 T: The effects of physiological motion
Katz‐Brull, R., & Lenkinski, R. E. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10670 · Cited by 20 · see citing works
Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging
Farr, N., Wang, Y., DʼAndrea, S., Gravelle, K., Hwang, J. H., & Lee, D. (2017) · Cancer Medicine · doi:10.1002/cam4.1062 · Cited by 19 · see citing works
Valette, J., Chaumeil, M. M., Guillermier, M., Bloch, G., Hantraye, P., & Lebon, V. (2008) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21661 · Cited by 19 · see citing works
Proton MR spectroscopy of delayed cerebral radiation in monkeys and humans after brachytherapy.
Kinoshita, K., Tada, E., Matsumoto, K., Asari, S., Ohmoto, T., & Itoh, T. (1997) · PubMed Central · Cited by 19 · see citing works
Echo‐Planar Diffusion Spectroscopic Imaging
Bito, Y., Hirata, S., Nabeshima, T., & Yamamoto, E. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330110 · Cited by 18 · see citing works
Landheer, K., & Juchem, C. (2019) · Magnetic Resonance in Medicine · doi:10.1002/mrm.27952 · Cited by 17 · see citing works
Advanced Diffusion MRI of the Visual System in Glaucoma: From Experimental Animal Models to Humans
Mendoza, M., Shotbolt, M., Faiq, M. A., Parra, C., & Chan, K. C. (2022) · Biology · doi:10.3390/biology11030454 · Cited by 16 · see citing works
Signal losses in diffusion preparation: Comparison between spin-echo, stimulated echo and SEASON
Schick, F. (1998) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/bf02662512 · Cited by 15 · see citing works
Machannab, J., Schick, F., Jacob, S., Lutz, O., & Claussen, C. D. (2000) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(99)00132-0 · Cited by 14 · see citing works
Lundell, H., Ingo, C., Dyrby, T. B., & Ronen, I. (2020) · NMR in Biomedicine · doi:10.1002/nbm.4304 · Cited by 12 · see citing works
Diffusion‐weighted J‐resolved spectroscopy
Landheer, K., Schulte, R. F., Geraghty, B. J., Hanstock, C. C., Chen, A. P., Cunningham, C. H., & Graham, S. J. (2016) · Magnetic Resonance in Medicine · doi:10.1002/mrm.26514 · Cited by 13 · see citing works
Diffusion tensor spectroscopic imaging of the human brain in children and adults
Fotso, K., Dager, S. R., Landow, A., Ackley, E. S., Myers, O., Dixon, M., Shaw, D., Corrigan, N. M., & Posse, S. (2016) · Magnetic Resonance in Medicine · doi:10.1002/mrm.26518 · Cited by 12 · see citing works
Self-citationCommunity‐Organized Resources for Reproducible MRS Data Analysis
Soher, B. J., Clarke, W. T., Wilson, M., Near, J., & Oeltzschner, G. (2022) · Magnetic Resonance in Medicine · doi:10.1002/mrm.29387 · Cited by 10 · see citing works
In Vivo Proton NMR Studies in Skeletal Musculature
Machann, J., Steidle, G., Thamer, C., Mader, I., & Schick, F. (2003) · Annual reports on NMR spectroscopy · doi:10.1016/s0066-4103(03)50001-1 · Cited by 10 · see citing works
Rapid acquisition diffusion MR spectroscopy of metabolites in human brain
Hanstock, C. C., & Beaulieu, C. (2020) · NMR in Biomedicine · doi:10.1002/nbm.4270 · Cited by 8 · see citing works
Diffusion-Weighted Magnetic Resonance Imaging
King, M. D., van Bruggen, N., Busza, A. L., & Turner, R. (1997) · Springer eBooks · doi:10.1007/978-1-4615-5863-7_8 · Cited by 8 · see citing works
Bito, Y., Hirata, K., Ebisu, T., Kawai, Y., Otake, Y., HIRATA, S., Shirai, T., Soutome, Y., Ochi, H., Yamamoto, E., et al. (2014) · Magnetic Resonance in Medical Sciences · doi:10.2463/mrms.2014-0024 · Cited by 7 · see citing works
Choi, C., Ogilvie, C. J., Malykhin, N. V., Ngo, J., Hartfeil, M. A. W., & Coupland, N. J. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20688 · Cited by 7 · see citing works
Mosso, J., Simičić, D., Lanz, B., Rolf Gruetter, A., & Cudalbu, C. (2023) · Magnetic Resonance in Medicine · doi:10.1002/mrm.29805 · Cited by 5 · see citing works
Diffusion‐weighted MRS of acetate in the rat brain
Dehghani, M., Kunz, N., Lanz, B., Yoshihara, H. A. I., & Rolf Gruetter, A. (2017) · NMR in Biomedicine · doi:10.1002/nbm.3768 · Cited by 6 · see citing works
Methods and Applications of Diffusion MRI
Bihan, D. L. (2007) · Encyclopedia of Magnetic Resonance · doi:10.1002/9780470034590.emrstm0309 · Cited by 6 · see citing works
Mougel, E., Malaquin, S., Vincent, M., & Valette, J. (2021) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2021.107113 · Cited by 5 · see citing works
Single Voxel Localized Proton NMR Spectroscopy of Human Brain In Vivo
Frahm, J., & Hänicke, W. (1996) · doi:10.1002/9780470034590.emrstm0507 · Cited by 5 · see citing works
Yu, C.-S., & Bower, S. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-7020-4591-2.00010-3 · Cited by 4 · see citing works
Diffusion Measurement in Phantoms and Tissues Using SLIM Localization
Yang, Y., Xu, S., Dawson, M. J., & Lauterbur, P. C. (1997) · Journal of Magnetic Resonance · doi:10.1006/jmre.1997.1257 · Cited by 4 · see citing works
- Authors
- Posse, S., Cuenod, C. A., & Le Bihan, D.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Posse, S
- Venue
- Radiology
- Published
- 1993-09
- Volume
- 188
- Issue
- 3
- Pages
- 719-725
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2055971737
- Cited by
- 122
- References
- 29
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 2 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 1 · 2012: 3
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
- Keywords
- apparent diffusion coefficient, brain metabolites, choline-containing compounds, creatine, phosphocreatine, N-acetylaspartate, motion correction, cardiac gating, phase correction
- MeSH terms
- Adult, Aspartic Acid, Brain Chemistry, Choline, Creatine, Female, Humans, Male, Magnetic Resonance Spectroscopy, Phosphocreatine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
