The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Human brain: Proton diffusion MR spectroscopy
Abstract
Diffusion of brain metabolites was measured in 10 healthy volunteers by using localized proton diffusion magnetic resonance (MR) spectroscopy. Measurements were conducted with a clinical MR imager by using a stimulated-echo pulse sequence (3,000/60 [repetition time msec/echo time msec], 200-msec mixing time) with additional outside-volume suppression. Motion artifacts due to macroscopic brain movements were compensated by means of peripheral cardiac gating and separate collection of individual spectroscopic acquisitions into a two-dimensional data matrix. Phase errors due to macroscopic motion were subsequently corrected in individual data traces prior to spectral averaging. Mean (+/- 1 standard deviation) apparent diffusion coefficients of choline-containing compounds ([0.13 +/- 0.03] x 10(-3) mm2/sec), creatine and phosphocreatine ([0.15 +/- 0.03] x 10(-3) mm2/sec), and N-acetyl aspartate ([0.18 +/- 0.02] x 10(-3) mm2/sec) were substantially smaller than that of water and were consistent with recently published data obtained in anesthetized and paralyzed animals. Adequate diffusion sensitivity for metabolites in the human brain can be obtained with clinical whole-body imagers despite macroscopic head and brain movements.
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“Diffusion MRI has also been used to investigate the diffusion of nonwater molecules in the human brain, notably metabolites and neurotransmitters (Posse et al., 1993).”
From 40 Years of diffusion MRI in the brain: From history to emerging frontiers (2026) · cites this paper as Posse et al., 1993
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40 Years of diffusion MRI in the brain: From history to emerging frontiers
Le Bihan, D. (2026) · Imaging Neuroscience · doi:10.1162/imag.a.1365
“Diffusion MRI has also been used to investigate the diffusion of nonwater molecules in the human brain, notably metabolites and neurotransmitters ( Posse et al., 1993).”
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From Brownian motion to the brain connectome: My perspective and historical view of diffusion MRI
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High‐resolution, volumetric diffusion‐weighted MR spectroscopic imaging of the brain
Wang, Z., Sutton, B. P., & Lam, F. (2025) · Magnetic Resonance in Medicine · doi:10.1002/mrm.30479
Metadata
- Authors
- Posse, S., Cuenod, C. A., & Le Bihan, D.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Posse, S
- Venue
- Radiology
- Published
- 1993-09
- Volume
- 188
- Issue
- 3
- Pages
- 719-725
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2055971737
- Cited by
- 122
- References
- 29
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 2 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 1 · 2012: 3
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Physical Sciences › Chemistry › Spectroscopy › NMR spectroscopy and applications
- Keywords
- apparent diffusion coefficient, brain metabolites, choline-containing compounds, creatine, phosphocreatine, N-acetylaspartate, motion correction, cardiac gating, phase correction
- MeSH terms
- Adult, Aspartic Acid, Brain Chemistry, Choline, Creatine, Female, Humans, Male, Magnetic Resonance Spectroscopy, Phosphocreatine
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