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Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging.
Abstract
PURPOSE: To determine the safety, pharmacokinetics, and magnetic resonance (MR) imaging results of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) as a contrast agent for use in hepatobiliary MR imaging. MATERIALS AND METHODS: Gd-EOB-DTPA was tested at doses of 10, 25, 50, and 100 mumol per kilogram of body weight. Results of laboratory tests, clinical measurements, and pharmacokinetic data were obtained in 44 healthy volunteers in a double-blind, randomized, placebo-controlled design. MR images were obtained in another 16 healthy volunteers before and up to 6 hours after fast intravenous administration of Gd-EOB-DTPA. RESULTS: Gd-EOB-DTPA was well tolerated, with no important side effects or changes in laboratory parameters. Homogeneous enhancement of liver parenchyma was observed immediately after injection of the contrast agent. Peak liver signal intensity was noted 20 minutes after injection, followed by plateaulike enhancement over about 2 hours. The common bile duct was hyperintense within 10 minutes after injection in all volunteers. CONCLUSION: Gd-EOB-DTPA is safe and efficient for MR imaging of the liver.
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Cited by
Huppertz, A., Balzer, T., Blakeborough, A., Breuer, J., Giovagnoni, A., Heinz-Peer, G., Laniado, M., Manfredi, R. M., Mathieu, D. G., Mueller, D., et al. (2004) · Radiology · doi:10.1148/radiol.2301020269 · Cited by 396
Self-citationIncorporation of excess gadolinium into human bone from medical contrast agents
Darrah, T. H., Prutsman-Pfeiffer, J. J., Poreda, R. J., Ellen Campbell, M., Hauschka, P. V., & Hannigan, R. E. (2009) · Metallomics · doi:10.1039/b905145g · Cited by 299
Gadolinium as a new emerging contaminant of aquatic environments
Rogowska, J., Olkowska, E., Ratajczyk, W., & Wolska, L. (2018) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4116 · Cited by 242
Gadoxetate acid-enhanced MR imaging for HCC: A review for clinicians
Chanyaputhipong, J., Low, S.-C. A., & Chow, P. K. H. (2011) · International Journal of Hepatology · doi:10.4061/2011/489342 · Cited by 41
Metadata
- Authors
- Hamm, B., Staks, T., Mühler, A., Bollow, M., Taupitz, M., Frenzel, T., Wolf, K. J., Weinmann, H. J., & Lange, L.
- Venue
- Radiology
- Published
- 1995-06
- Volume
- 195
- Issue
- 3
- Pages
- 785-792
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2121751309
- Cited by
- 575
- References
- 0
- FWCI
- 11.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging. https://app.cochat.ai/papers/10.1148/radiology.195.3.7754011
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- Hamm, B., Staks, T., Mühler, A., Bollow, M., Taupitz, M., Frenzel, T., Wolf, K. J., Weinmann, H. J., & Lange, L. (1995). Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging. Radiology. https://doi.org/10.1148/radiology.195.3.7754011
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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