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Superparamagnetic iron oxide--enhanced versus gadolinium-enhanced MR imaging for differential diagnosis of focal liver lesions.
Abstract
PURPOSE: To assess AMI-25- versus gadolinium-enhanced magnetic resonance (MR) imaging in the differential diagnosis of liver tumors. MATERIALS AND METHODS: Twenty-nine patients with liver tumors underwent unenhanced, AMI-25-enhanced (15 micromol/kg), and gadolinium-enhanced(0.1 mmol/kg) imaging within 2 weeks. RESULTS: A significant (P< .05) difference in percentage signal intensity loss (PSIL) was seen in benign tumors on AMI-25-enhanced proton-density-weighted images (nine focal nodular hyperplasia [FNH], 41%; one adenoma, 32.4%) versus malignant tumors. Gadolinium-enhanced T1-weighted gradient-echo images showed strong enhancement in benign lesions (seven FNH, 147.5%; one adenoma, 91.3%) and moderate enhancement in malignant tumors (eight hepatocellular carcinomas, 116.2%, 11 metastases, 39.7%). Receiver operating characteristic analysis revealed a threshold PSIL of 10% on AMI-25-enhanced images as the most essential criteria to distinguish benign from malignant lesions (sensitivity, 88%; specificity. 89%). Interobserver analysis for two observers revealed specificity of 93% for AMI-25-enhanced imaging versus 81.5% for gadolinium-enhanced MR imaging. CONCLUSION: AMI-25 decreased the SI of benign tumors and helped differentiate benign from malignant tumors.
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Citations
Cited by
Reddy, L. H., Arias, J. L., Nicolas, J., & Couvreur, P. (2012) · Chemical Reviews · doi:10.1021/cr300068p · Cited by 2,010
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Wahsner, J., Gale, E. M., Rodríguez-Rodríguez, A., & Caravan, P. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00363 · Cited by 1,603
Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging
Thorek, D. L. J., Chen, A. K., Czupryna, J., & Tsourkas, A. (2006) · Annals of Biomedical Engineering · doi:10.1007/s10439-005-9002-7 · Cited by 772
Superparamagnetic iron oxide based MRI contrast agents: Current status of clinical application.
Wáng, Y. X. J. (2011) · PubMed · doi:10.3978/j.issn.2223-4292.2011.08.03 · Cited by 613
Grazioli, L., Morana, G., Kirchin, M. A., & Schneider, G. (2005) · Radiology · doi:10.1148/radiol.2361040338 · Cited by 354
Metadata
- Authors
- Vogl, T. J., Hammerstingl, R., Schwarz, W., Mack, M. G., Müller, P. K., Pegios, W., Keck, H., Eibl-Eibesfeldt, A., Hoelzl, J., Woessmer, B., Bergman, C., & Felix, R.
- Venue
- Radiology
- Published
- 1996-03
- Volume
- 198
- Issue
- 3
- Pages
- 881-887
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2077387095
- Cited by
- 186
- References
- 0
- FWCI
- 19.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Superparamagnetic iron oxide--enhanced versus gadolinium-enhanced MR imaging for differential diagnosis of focal liver lesions. https://app.cochat.ai/papers/10.1148/radiology.198.3.8628887
- The paper
- Vogl, T. J., Hammerstingl, R., Schwarz, W., Mack, M. G., Müller, P. K., Pegios, W., Keck, H., Eibl-Eibesfeldt, A., Hoelzl, J., Woessmer, B., Bergman, C., & Felix, R. (1996). Superparamagnetic iron oxide--enhanced versus gadolinium-enhanced MR imaging for differential diagnosis of focal liver lesions. Radiology. https://doi.org/10.1148/radiology.198.3.8628887
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