The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Human Acute Cerebral Ischemia: Detection of Changes in Water Diffusion Anisotropy by Using MR Imaging
Abstract
PURPOSE: To (a) determine the optimal choice of a scalar metric of anisotropy and (b) determine by means of magnetic resonance imaging if changes in diffusion anisotropy occurred in acute human ischemic stroke. MATERIALS AND METHODS: The full diffusion tensor over the entire brain was measured. To optimize the choice of a scalar anisotropy metric, the performances of scalar indices in simulated models and in a healthy volunteer were analyzed. The anisotropy, trace apparent diffusion coefficient (ADC), and eigenvalues of the diffusion tensor in lesions and contralateral normal brain were compared in 50 patients with stroke. RESULTS: Changes in anisotropy in patients were quantified by using fractional anisotropy because it provided the best performance in terms of contrast-to-noise ratio as a function of signal-to-noise ratio in simulations. The anisotropy of ischemic white matter decreased (P = .01). Changes in anisotropy in ischemic gray matter were not significant (P = .63). The trace ADC decreased for ischemic gray matter and white matter (P < .001). The first and second eigenvalues decreased in both ischemic gray and ischemic white matter (P < .001). The third eigenvalue decreased in ischemic gray (P = .001) and white matter (P = .03). CONCLUSION: Gray matter is mildly anisotropic in normal and early ischemic states. However, early white matter ischemia is associated with not only changes in trace ADC values but also significant changes in the anisotropy, or shape, of the water self-diffusion tensor.
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Cites
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Cited by
Diffusion tensor imaging of the brain
Alexander, A. L., Lee, J. E., Lazar, M., & Field, A. S. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.05.011 · Cited by 2,747
Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review
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Self-citation“Squashing peanuts and smashing pumpkins”: How noise distorts diffusion‐weighted MR data
Jones, D. K., & Basser, P. J. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20283 · Cited by 587
Diffusion Tensor MR Imaging and Fiber Tractography: Theoretic Underpinnings
Mukherjee, P., Berman, J. I., Chung, S. W., Hess, C. P., & Henry, R. G. (2008) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1051 · Cited by 521
Metadata
- Authors
- Sorensen, A. G., Wu, O., Copen, W. A., Davis, T. L., Gonzalez, R. G., Koroshetz, W. J., Reese, T. G., Rosen, B. R., Wedeen, V. J., & Weisskoff, R. M.
- Venue
- Radiology
- Published
- 1999-09
- Volume
- 212
- Issue
- 3
- Pages
- 785-792
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2131096301
- Cited by
- 300
- References
- 38
- FWCI
- 13.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Sorensen, A. G., Wu, O., Copen, W. A., Davis, T. L., Gonzalez, R. G., Koroshetz, W. J., Reese, T. G., Rosen, B. R., Wedeen, V. J., & Weisskoff, R. M. (1999). Human Acute Cerebral Ischemia: Detection of Changes in Water Diffusion Anisotropy by Using MR Imaging. Radiology. https://doi.org/10.1148/radiology.212.3.r99se24785
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