The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Hepatobiliary-specific MR Contrast Agents: Role in Imaging the Liver and Biliary Tree
Abstract
Hepatobiliary-specific contrast agents are one of several classes of contrast agents available for magnetic resonance (MR) imaging of the liver. These agents are taken up by functioning hepatocytes and excreted in the bile, and their paramagnetic properties cause shortening of the longitudinal relaxation time (T1) of the liver and biliary tree. The three contrast agents that have been developed are mangafodipir trisodium (Mn-DPDP), gadobenate dimeglumine (Gd-BOPTA), and gadoxetic acid (Gd-EOB-DTPA). These three MR contrast agents vary in mode of administration and dose, mechanism of cellular uptake, degree of excretion through the biliary pathway, and imaging characteristics. In the liver, hepatobiliary-specific agents can be used to improve lesion detection, to characterize lesions as hepatocellular or nonhepatocellular, and to specifically characterize some hepatocellular lesions, notably focal nodular hyperplasia. Biliary excretion of these agents can be used to evaluate the anatomic structure and function of the biliary tree. In the future, hepatobiliary-specific contrast agents may have wider applications, such as grading of cirrhosis and quantification of liver function.
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Cites
Colorectal Liver Metastases: CT, MR Imaging, and PET for Diagnosis—Meta-analysis
Bipat, S., van Leeuwen, M. S., Comans, E. F. I., Pijl, M. E. J., Bossuyt, P. M. M., Zwinderman, A. H., & Stoker, J. (2005) · Radiology · doi:10.1148/radiol.2371042060 · Cited by 544
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Huppertz, A., Balzer, T., Blakeborough, A., Breuer, J., Giovagnoni, A., Heinz-Peer, G., Laniado, M., Manfredi, R. M., Mathieu, D. G., Mueller, D., et al. (2004) · Radiology · doi:10.1148/radiol.2301020269 · Cited by 396
For the European EOB-study group, Hammerstingl, R., Huppertz, A., Breuer, J., Balzer, T., Blakeborough, A., Carter, R., Fusté, L. C., Heinz-Peer, G., Judmaier, W., et al. (2008) · European Radiology · doi:10.1007/s00330-007-0716-9 · Cited by 384
Huppertz, A., Haraida, S., Kraus, A., Zech, C. J., Scheidler, J., Breuer, J., Helmberger, T. K., & Reiser, M. F. (2005) · Radiology · doi:10.1148/radiol.2342040278 · Cited by 370
Grazioli, L., Morana, G., Kirchin, M. A., & Schneider, G. (2005) · Radiology · doi:10.1148/radiol.2361040338 · Cited by 354
Contrast Agents for MR Imaging of the Liver
Semelka, R. C., & Helmberger, T. K. G. (2001) · Radiology · doi:10.1148/radiology.218.1.r01ja2427 · Cited by 337
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Wertman, R., Altun, E., Martin, D. R., Mitchell, D. G., Leyendecker, J. R., O'Malley, R. B., Parsons, D. J., Fuller, E. R., & Semelka, R. C. (2008) · Radiology · doi:10.1148/radiol.2483072093 · Cited by 187
Petersein, J., Spinazzi, A., Giovagnoni, A., Soyer, P., Terrier, F., Lencioni, R., Bartolozzi, C., Grazioli, L., Chiesa, A., Manfredi, R., et al. (2000) · Radiology · doi:10.1148/radiology.215.3.r00jn14727 · Cited by 187
Cited by
Gadoxetate acid-enhanced MR imaging for HCC: A review for clinicians
Chanyaputhipong, J., Low, S.-C. A., & Chow, P. K. H. (2011) · International Journal of Hepatology · doi:10.4061/2011/489342 · Cited by 41
Jang, K. M., Kim, S. H., Kim, Y. K., Song, K. D., Lee, S. J., & Choi, D. (2015) · European Journal of Radiology · doi:10.1016/j.ejrad.2015.05.012 · Cited by 31
Metadata
- Authors
- Seale, M. K., Catalano, O. A., Saini, S., Hahn, P. F., & Sahani, D. V.
- Venue
- RadioGraphics
- Published
- 2009-10
- Volume
- 29
- Issue
- 6
- Pages
- 1725-1748
- ISSN
- 0271-5333 (ISSN-L)
- 1527-1323
- OpenAlex
- W1980440335
- Cited by
- 388
- References
- 25
- FWCI
- 19.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hepatobiliary-specific MR Contrast Agents: Role in Imaging the Liver and Biliary Tree. https://app.cochat.ai/papers/10.1148/rg.296095515
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- Seale, M. K., Catalano, O. A., Saini, S., Hahn, P. F., & Sahani, D. V. (2009). Hepatobiliary-specific MR Contrast Agents: Role in Imaging the Liver and Biliary Tree. RadioGraphics. https://doi.org/10.1148/rg.296095515
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
