Cited by 505Opioid Use Disorder TreatmentNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

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The Neurobiology of Opioid Dependence: Implications for Treatment

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Kosten, Thomas, George, Tony·2002·Science & Practice Perspectives

DOI 10.1151/spp021113PMC PMC2851054

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Abstract

Opioid tolerance, dependence, and addiction are all manifestations of brain changes resulting from chronic opioid abuse. The opioid abuser's struggle for recovery is in great part a struggle to overcome the effects of these changes. Medications such as methadone, LAAM, buprenorphine, and naltrexone act on the same brain structures and processes as addictive opioids, but with protective or normalizing effects. Despite the effectiveness of medications, they must be used in conjunction with appropriate psychosocial treatments.

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Authors: Kosten, T., & George, T.
Affiliations: Yale University (US)
Corresponding author: Kosten, Thomas
ORCID: Kosten, Thomas
George, Tony
Venue: Science & Practice Perspectives
Publisher: NIDA/RTI International
Published: 2002-07
Volume: 1
Issue: 1
Pages: 13-20
ISSN: 1930-4307 (ISSN-L)
1930-4315
DOI: 10.1151/spp021113
PMC: PMC2851054
OpenAlex: W1997980357
Cited by: 505
References: 24
Citations by year: 2026: 34 · 2025: 46 · 2024: 38 · 2023: 53 · 2022: 56 · 2021: 55 · 2020: 46 · 2019: 33 · 2018: 32 · 2017: 27 · 2016: 22 · 2015: 18 · 2014: 8 · 2013: 5 · 2012: 2
FWCI: 1.75
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science & Practice Perspectives (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (R01-DA-1-4039, P50 DA12762, K05‐DA00454, R01-DA-1-3672, K12 DA00167)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: opioid use disorder, opioid tolerance, neurobiology of addiction, methadone maintenance treatment, LAAM, buprenorphine, naltrexone, opioid antagonists, psychosocial interventions, addiction treatment
MeSH terms: Analgesics, Opioid, Brain, Humans, Models, Neurological, Narcotic Antagonists, Opioid-Related Disorders, Receptors, Opioid, Behavior, Addictive

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