Cited by 871Barrier Structure and Function StudiesAcute Ischemic Stroke ManagementNeuroinflammation and Neurodegeneration Mechanisms

Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke

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Yang, Changjun, Hawkins, Kimberly E., Doré, Sylvain, Candelario-Jalil, Eduardo·2019·American Journal of Physiology-Cell Physiology

Abstract

As part of the neurovascular unit, the blood-brain barrier (BBB) is a unique, dynamic regulatory boundary that limits and regulates the exchange of molecules, ions, and cells between the blood and the central nervous system. Disruption of the BBB plays an important role in the development of neurological dysfunction in ischemic stroke. Blood-borne substances and cells have restricted access to the brain due to the presence of tight junctions between the endothelial cells of the BBB. Following stroke, there is loss of BBB tight junction integrity, leading to increased paracellular permeability, which results in vasogenic edema, hemorrhagic transformation, and increased mortality. Thus, understanding principal mediators and molecular mechanisms involved in BBB disruption is critical for the development of novel therapeutics to treat ischemic stroke. This review discusses the current knowledge of how neuroinflammation contributes to BBB damage in ischemic stroke. Specifically, we provide an updated overview of the role of cytokines, chemokines, oxidative and nitrosative stress, adhesion molecules, matrix metalloproteinases, and vascular endothelial growth factor as well as the role of different cell types in the regulation of BBB permeability in ischemic stroke.

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Authors
Yang, C., Hawkins, K. E., Doré, S., & Candelario-Jalil, E.
Affiliations
  • University of Florida (US)
  • Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida
Venue
American Journal of Physiology-Cell Physiology
Published
2019-02-01
Volume
316
Issue
2
Pages
C135-C153
ISSN
  • 0363-6143 (ISSN-L)
  • 1522-1563
OpenAlex
W2899197889
Cited by
871
References
256
Citations by year
2026: 92 · 2025: 167 · 2024: 148 · 2023: 140 · 2022: 138 · 2021: 108 · 2020: 59 · 2019: 19
FWCI
4.40
Type
journal article
Language
en
Open access
Locations
  • American Journal of Physiology-Cell Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NS065849, NS103094, NS095166)
  • HHS | NIH | National Center for Complementary and Alternative Medicine (AT007429)
  • McKnight Foundation
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
blood-brain barrier disruption, ischemic stroke, neuroinflammation, tight junctions, blood-brain barrier permeability, vasogenic edema, hemorrhagic transformation, cytokines, chemokines, oxidative stress, nitrosative stress, adhesion molecules, matrix metalloproteinases, vascular endothelial growth factor, endothelial cells, neurovascular unit
MeSH terms
Animals, Biological Transport, Blood-Brain Barrier, Brain Ischemia, Humans, Permeability, Oxidative Stress, Inflammation Mediators, Tight Junctions, Stroke, Endothelial Cells

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