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Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors

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Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides

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Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs

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Identification of human, rat and mouse hydrolyzing enzymes bioconverting amino acid ester prodrug of ketoprofen

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GLUT 1 ‐mediated venlafaxine‐thiamine disulfide system‐glucose conjugates with “lock‐in” function for central nervous system delivery

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Practical approaches to evaluating and optimizing brain exposure in early drug discovery

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Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide

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Design and Synthesis of Brain Penetrant Trypanocidal N -Myristoyltransferase Inhibitors

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Discovery of Potent, Selective, and Brain-Penetrant 1H-Pyrazol-5-yl-1H-pyrrolo[2,3-b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors

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Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability

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VU6007477, a Novel M 1 PAM Based on a Pyrrolo[2,3- b ]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events

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Novel application of capillary electrophoresis with a liposome coated capillary for prediction of blood-brain barrier permeability

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Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5- b ]pyridazines for the Treatment of Human African Trypanosomiasis

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Characterization of the neurotoxic potential of m-methoxy-MPTP and the use of its N-ethyl analog as a means of avoiding exposure to a possible Parkinson-causing agent

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Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS

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A Practical Perspective on the Evaluation of Small Molecule CNS Penetration in Drug Discovery

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Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug

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Developing RNA Aptamers for Potential Treatment of Neurological Diseases

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Design, Synthesis and Evaluation of Dual-targeting Prodrug Co-modified by Organic Amine and L-ascorbic Acid for CNS Delivery

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Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential

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Altering Nitrogen Heterocycles of AZD2461 Affords High Affinity Poly(ADP-ribose) Polymerase-1 Inhibitors with Decreased P-Glycoprotein Interactions

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Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system

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Extracellular Vesicles: A Review of Their Therapeutic Potentials, Sources, Biodistribution, and Administration Routes

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NLRP3 Inflammasome-Mediated Neuroinflammation and Related Mitochondrial Impairment in Parkinson’s Disease

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Differential Signaling Pathways in Medulloblastoma: Nano-biomedicine Targeting Non-coding Epigenetics to Improve Current and Future Therapeutics

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Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics

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Drug Delivery Across the Blood–Brain Barrier: A New Strategy for the Treatment of Neurological Diseases

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Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy

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Recent advances in small molecular near-infrared fluorescence probes for a targeted diagnosis of the Alzheimer disease

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Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors

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A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatment

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A novel NIR fluorescent probe for copper( ii ) imaging in Parkinson's disease mouse brain

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Biomaterials in Traumatic Brain Injury: Perspectives and Challenges

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The risk associated with organophosphorus nerve agents: from their discovery to their unavoidable threat, current medical countermeasures and perspectives

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Synergistic Modulation by Halogens and Pyridine Crossing the Blood–Brain Barrier for In Situ Visualization of Thiol Flux in the Epileptic Brain

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Myricetin Oligomer Triggers Multi-Receptor Mediated Penetration and Autophagic Restoration of Blood-Brain Barrier for Ischemic Stroke Treatment

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In Silico Study in MPO and Molecular Docking of the Synthetic Drynaran Analogues Against the Chronic Tinnitus: Modulation of the M1 Muscarinic Acetylcholine Receptor

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Advances in nanoparticle-based therapeutics for ischemic stroke: Enhancing drug delivery and efficacy

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Discovery of a Hydroxylamine-Based Brain-Penetrant EGFR Inhibitor for Metastatic Non-Small-Cell Lung Cancer

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Direct Synthesis of α- and β-2′-Deoxynucleosides with Stereodirecting Phosphine Oxide via Remote Participation

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Discovery of a brain-permeable bromodomain and extra terminal domain (BET) inhibitor with selectivity for BD1 for the treatment of multiple sclerosis

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Discovery of 4-benzylpiperazinequinoline BChE inhibitor that suppresses neuroinflammation for the treatment of Alzheimer's disease

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Applications of hydrogels and nanoparticles in the treatment of traumatic brain injury

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Simultaneous Imaging of pH and Peroxynitrite in the Endoplasmic Reticulum and Mitochondria: Revealing Organelle Interactions in Alzheimer’s Disease Pathogenesis

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Selective Covalent Inhibiting JNK3 by Small Molecules for Parkinson's Diseases

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In silico Prediction of ADMET/Drug-likeness Properties of Bioactive Phloroglucinols from Hypericum Genus

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Real-Time Monitoring of Tyrosine Hydroxylase Activity with a Ratiometric Fluorescent Probe

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A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors

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Small‐Molecule Regulators for Gene Switches to Program Mammalian Cell Behaviour

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Peering into the Brain’s Estrogen Receptors: PET Tracers for Visualization of Nuclear and Extranuclear Estrogen Receptors in Brain Disorders

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A 3D generation framework using diffusion model and reinforcement learning to generate multi-target compounds with desired properties

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Generation of a Pure Culture of Neuron-like Cells with a Glutamatergic Phenotype from Mouse Astrocytes

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Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy

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Advances in Molecular Imaging of VEGFRs: Innovations in Imaging and Therapeutics

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Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy

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Molecular Windows into the Brain: Advances in BBB-Penetrable NIR Fluorescent Imaging Probes

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BODIPY‐Based Small‐Molecule Photoacoustic Probes for Biomedical Imaging

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An Overview of Nanocapsule and Lipid Nanocapsule: Recent Developments and Future Prospects

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Pharmacological modulation of chloride channels as a therapeutic strategy for neurological disorders

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Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations

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Novel 4-Aryl-4H-chromene derivative displayed excellent in vivo anti-glioblastoma efficacy as the microtubule-targeting agent

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Development of Brain Penetrant Pyridazine Pantothenate Kinase Activators

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Biodegradable lipid nanoparticles for genome editing in the brain via intrathecal administration

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Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging

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