The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Cellular Mechanisms of Tissue Fibrosis. 4. Structural and functional consequences of skeletal muscle fibrosis
Open accessAbstract
Skeletal muscle fibrosis can be a devastating clinical problem that arises from many causes, including primary skeletal muscle tissue diseases, as seen in the muscular dystrophies, or it can be secondary to events that include trauma to muscle or brain injury. The cellular source of activated fibroblasts (myofibroblasts) may include resident fibroblasts, adult muscle stem cells, or inflammatory or perivascular cells, depending on the model studied. Even though it is likely that there is no single source for all myofibroblasts, a common mechanism for the production of fibrosis is via the transforming growth factor-β/phosphorylated Smad3 pathway. This pathway and its downstream targets thus provide loci for antifibrotic therapies, as do methods for blocking the transdifferentiation of progenitors into activated fibroblasts. A structural model for the extracellular collagen network of skeletal muscle is needed so that measurements of collagen content, morphology, and gene expression can be related to mechanical properties. Approaches used to study fibrosis in tissues, such as lung, kidney, and liver, need to be applied to studies of skeletal muscle to identify ways to prevent or even cure the devastating maladies of skeletal muscle.
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Cites
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Cited by
Csapo, R., Gumpenberger, M., & Wessner, B. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00253 · Cited by 429
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Sinha, U., Malis, V., Csapo, R., Narici, M., & Sinha, S. (2020) · European Journal of Translational Myology · doi:10.4081/ejtm.2019.8935 · Cited by 8
Metadata
- Authors
- Lieber, R. L., & Ward, S. R.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2013-08-01
- Volume
- 305
- Issue
- 3
- Pages
- C241-C252
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W1965761285
- Cited by
- 307
- References
- 18
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Lieber, R. L., & Ward, S. R. (2013). Cellular Mechanisms of Tissue Fibrosis. 4. Structural and functional consequences of skeletal muscle fibrosis. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00173.2013
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