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Cited by 300

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Role of reactive oxygen species and NAD(P)H oxidase in α1-adrenoceptor signaling in adult rat cardiac myocytes

Xiao, Lei, Pimentel, David R., Wang, Jing, Singh, Krishna, Colucci, Wilson S., Sawyer, Douglas B.·2002·American Journal of Physiology-Cell Physiology
DOI 10.1152/ajpcell.00254.2001
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Abstract

We recently reported that α 1-adrenoceptor (α 1-AR) stimulation induces hypertrophy via activation of the mitogen/extracellular signal-regulated kinase (MEK) 1/2-extracellular signal-regulated kinase (ERK) 1/2 pathway and generates reactive oxygen species (ROS) in adult rat ventricular myocytes (ARVM). Here we investigate the intracellular source of ROS in ARVM and the mechanism by which ROS activate hypertrophic signaling after α 1-AR stimulation. Pretreatment of ARVM with the ROS scavenger Mn(III)terakis(1-methyl-4-pyridyl) porphyrin pentachloride (MnTMPyP) completely inhibited the α 1-AR-stimulated activation of Ras-MEK1/2-ERK1/2. Direct addition of H 2 O 2 or the superoxide generator menadione activated ERK1/2, which is also prevented by MnTMPyP pretreatment. We found that ARVM express gp91 phox, p22 phox, p67 phox, and p47 phox, four major components of NAD(P)H oxidase, and that α 1-AR-stimulated ERK1/2 activation was blocked by four structurally unrelated inhibitors of NAD(P)H oxidase [diphenyleneiodonium, phenylarsine oxide, 4-(2-aminoethyl)benzenesulfonyl fluoride, and cadmium]. Conversely, inhibitors for other potential ROS-producing systems, including mitochondrial electron transport chain, nitric oxide synthase, xanthine oxidase, and cyclooxygenase, had no effect on α 1-AR-stimulated ERK1/2 activation. Taken together, our results show that ventricular myocytes express components of an NAD(P)H oxidase that appear to be involved in α 1-AR-stimulated hypertrophic signaling via ROS-mediated activation of Ras-MEK1/2-ERK1/2.

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Metadata

Authors
Xiao, L., Pimentel, D. R., Wang, J., Singh, K., Colucci, W. S., & Sawyer, D. B.
Venue
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Published
2002-04-01
Volume
282
Issue
4
Pages
C926-C934
ISSN
  • 0363-6143 (ISSN-L)
  • 1522-1563
DOI
10.1152/ajpcell.00254.2001
OpenAlex
W2082452850
Cited by
300
References
40
FWCI
7.88
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Role of reactive oxygen species and NAD(P)H oxidase in α1-adrenoceptor signaling in adult rat cardiac myocytes. https://app.cochat.ai/papers/10.1152/ajpcell.00254.2001
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Xiao, L., Pimentel, D. R., Wang, J., Singh, K., Colucci, W. S., & Sawyer, D. B. (2002). Role of reactive oxygen species and NAD(P)H oxidase in α1-adrenoceptor signaling in adult rat cardiac myocytes. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00254.2001

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.