The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Regulation of cell proliferation by hypoxia-inducible factors
Open accessAbstract
Hypoxia is a physiological cue that impacts diverse physiological processes, including energy metabolism, autophagy, cell motility, angiogenesis, and erythropoiesis. One of the key cell-autonomous effects of hypoxia is as a modulator of cell proliferation. For most cell types, hypoxia induces decreased cell proliferation, since an increased number of cells, with a consequent increase in O 2 demand, would only exacerbate hypoxic stress. However, certain cell populations maintain cell proliferation in the face of hypoxia. This is a common pathological hallmark of cancers, but can also serve a physiological function, as in the maintenance of stem cell populations that reside in a hypoxic niche. This review will discuss major molecular mechanisms by which hypoxia regulates cell proliferation in different cell populations, with a particular focus on the role of hypoxia-inducible factors.
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Mechanisms of hypoxia signalling: new implications for nephrology
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HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells
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Metadata
- Authors
- Hubbi, M. E., & Semenza, G. L.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2015-12-15
- Volume
- 309
- Issue
- 12
- Pages
- C775-C782
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2180975946
- Cited by
- 300
- References
- 117
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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