Novel role for α v β 5 -integrin in retinal adhesion and its diurnal peak
Open accessAbstract
alpha(v)beta(5)-Integrin is the sole integrin receptor at the retinal pigment epithelium (RPE)-photoreceptor interface and promotes RPE phagocytic signaling to the tyrosine kinase Mer tyrosine kinase (MerTK) once a day in response to circadian photoreceptor shedding. Herein we identify a novel role for alpha(v)beta(5)-integrin in permanent RPE-photoreceptor adhesion that is independent of alpha(v)beta(5)'s function in retinal phagocytosis. To compare retinal adhesion of wild-type and beta(5)-integrin(-/-) mice, we mechanically separated RPE and neural retina and quantified RPE protein and pigment retention with the neural retina. Lack of alpha(v)beta(5)-integrin with normal expression of other RPE integrins greatly weakened retinal adhesion in young mice and accelerated its age-dependent decline. Unexpectedly, the strength of wild-type retinal adhesion varied with a diurnal rhythm that peaked 3.5 h after light onset, after the completion of phagocytosis, when integrin signaling to MerTK is minimal. Permanent alpha(v)beta(5) receptor deficiency attenuated the diurnal peak of retinal adhesion in beta(5)-integrin(-/-) mice. These results identify alpha(v)beta(5)-integrin as the first RPE receptor that contributes to retinal adhesion, a vital mechanism for long-term photoreceptor function and viability. Furthermore, they indicate that alpha(v)beta(5) receptors at the same apical plasma membrane domain of RPE cells fulfill two separate functions that are synchronized by different diurnal rhythms.
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The strength of retinal adhesion peaked 3.5 h after light onset, past the phagocytic peak.
“The strength of adhesion peaked 3.5 h after light onset, i.e., past the phagocytic peak (Nandrot et al., 2006).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Nandrot et al., 2006
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- Authors
- Nandrot, E. F., Anand, M., Sircar, M., & Finnemann, S. C.
- Affiliations
- Cornell University (US)
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2006-04
- Volume
- 290
- Issue
- 4
- Pages
- C1256-C1262
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- PMC
- PMC3237192
- OpenAlex
- W2337798073
- Cited by
- 72
- References
- 28
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 3 · 2020: 4 · 2019: 1 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 6
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Cell Physiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Research to Prevent Blindness
- National Eye Institute (R01EY013295, EY-13295, EY-14184, R03EY014184)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- alpha v beta 5 integrin, retinal pigment epithelium, diurnal cycle, circadian rhythm, MERTK, integrin signaling, pigment retention
- MeSH terms
- Ezrin, Retinoid Isomerohydrolase, Animals, Carrier Proteins, Cell Adhesion, Circadian Rhythm, Cytoskeletal Proteins, Eye Proteins, Phagocytosis, Pigment Epithelium of Eye, Signal Transduction, Integrins, Mice, Knockout, Receptors, Vitronectin, cis-trans-Isomerases, Photoreceptor Cells, Vertebrate, Protein Subunits, Integrin beta Chains, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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