Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking αvβ5 integrin
Open accessAbstract
Daily phagocytosis by the retinal pigment epithelium (RPE) of spent photoreceptor outer segment fragments is critical for vision. In the retina, early morning circadian photoreceptor rod shedding precedes synchronized uptake of shed photoreceptor particles by RPE cells. In vitro, RPE cells use the integrin receptor alphavbeta5 for particle binding. Here, we tested RPE phagocytosis and retinal function in beta5 integrin--deficient mice, which specifically lack alphavbeta5 receptors. Retinal photoresponses severely declined with age in beta5-/- mice, whose RPE accumulated autofluorescent storage bodies that are hallmarks of human retinal aging and disease. beta5-/- RPE in culture failed to take up isolated photoreceptor particles. beta5-/- RPE in vivo retained basal uptake levels but lacked the burst of phagocytic activity that followed circadian photoreceptor shedding in wild-type RPE. Rhythmic activation of focal adhesion and Mer tyrosine kinases that mediate wild-type retinal phagocytosis was also completely absent in beta5-/- retina. These results demonstrate an essential role for alphavbeta5 integrin receptors and their downstream signaling pathways in synchronizing retinal phagocytosis. Furthermore, they identify the beta5-/- integrin mouse strain as a new animal model of age-related retinal dysfunction.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
β5−/− mice do not exhibit the characteristic peak of tyrosine phosphorylation seen in MERTK after light onset.
“Indeed, β5−/− mice do not exhibit the characteristic peak of tyrosine phosphorylation seen in MERTK after light onset (Nandrot et al., 2004).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Nandrot et al., 2004
FAK operates downstream of αvβ5 integrin and shows a diurnal pattern of phosphorylation similar to that of MERTK, peaking after light onset and diminishing as phagosome degradation proceeds.
“FAK operates downstream of αvβ5 integrin and shows a diurnal pattern of phosphorylation similar to that of MERTK, peaking after light onset and diminishing as phagosome degradation proceeds (Nandrot et al., 2004).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Nandrot et al., 2004
In the absence of the β5 subunit, the daily rhythm of phagocytosis is lost and while OS ingestion is impaired, it is not absent, suggesting the existence of potential β5 compensatory mechanisms.
“In the absence of the β5 subunit, the daily rhythm of phagocytosis is lost and while OS ingestion is impaired, it is not absent (Nandrot et al., 2004), suggesting the existence of potential β5 compensatory mechanisms.”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Nandrot et al., 2004
Secondary effects on the expression of receptors involved in POS binding and phagocytosis due to the deletion of Atg5 were not observed in Atg5ΔRPE RPE cells compared to control.
“Secondary effects on the expression of receptors involved in POS binding and phagocytosis (Gal et al., 2000; Nandrot et al., 2007; Nandrot et al., 2004) due to the deletion of Atg5 were not observed in Atg5ΔRPE RPE cells compared to control (Figure S1).”
From Noncanonical autophagy promotes the visual cycle (2013) · cites this paper as Nandrot et al., 2004
In WT RPE, phagosome numbers reached a sharp peak within an hour of lights on.
“In WT RPE, phagosome numbers reached a sharp peak within an hour of lights on (Figure 4A) (LaVail, 1980; Gibbs et al., 2003; Nandrot et al., 2004).”
From Microtubule-associated protein 1 light chain 3B, (LC3B) is necessary to maintain lipid-mediated homeostasis in the retinal pigment epithelium (2018) · cites this paper as Nandrot et al., 2004
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Albert, M. L., Pearce, S. F. A., Francisco, L. M., Sauter, B., Roy, P., Silverstein, R. L., & Bhardwaj, N. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.7.1359 · Cited by 1,234 · see citing works
Phagocytosis and clearance of apoptotic cells is mediated by MER
Scott, R. S., McMahon, E. J., Pop, S. M., Reap, E. A., Caricchio, R., Cohen, P. L., Earp, H. S., & Matsushima, G. K. (2001) · Nature · doi:10.1038/35075603 · Cited by 1,215 · see citing works
The renewal of photoreceptor cell outer segments
Young, R. W. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.33.1.61 · Cited by 1,184 · cited 1× · see citing works
“In the retina, photoreceptor rods and cones continuously renew their light-sensitive outer segments (1, 2).”
BackgroundMutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat
D'Cruz, P. M. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.4.645 · Cited by 869 · see citing works
Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis
Savill, J., Dransfield, I., Hogg, N., & Haslett, C. (1990) · Nature · doi:10.1038/343170a0 · Cited by 846 · see citing works
INHERITED RETINAL DYSTROPHY IN THE RAT
Dowling, J. E., & Sidman, R. L. (1962) · The Journal of Cell Biology · doi:10.1083/jcb.14.1.73 · Cited by 804 · see citing works
Rod outer segment disk shedding in rat retina: relationship to cyclic lighting
LaVail, M. M. (1976) · Science · doi:10.1126/science.982063 · Cited by 689 · see citing works
Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins
Reynolds, L. E., Wyder, L., Lively, J. C., Taverna, D., Robinson, S. D., Huang, X., Sheppard, D., Hynes, R. O., & Hodivala‐Dilke, K. (2002) · Nature Medicine · doi:10.1038/nm0102-27 · Cited by 614 · see citing works
Self-citationTHE ROLE OF THE PIGMENT EPITHELIUM IN THE ETIOLOGY OF INHERITED RETINAL DYSTROPHY IN THE RAT
Bok, D., & Hall, M. O. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.49.3.664 · Cited by 537 · see citing works
Mullen, R. J., & LaVail, M. M. (1976) · Science · doi:10.1126/science.1265483 · Cited by 530 · see citing works
Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration.
Holz, F. G., Bellman, C., STAUDT, S., Schütt, F., & Völcher, H. E. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(01)01394-0 · Cited by 426 · see citing works
Feeney, L. (1978) · PubMed · Cited by 397 · see citing works
CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis.
Ren, Y., Silverstein, R. L., Allen, J., & Savill, J. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.5.1857 · Cited by 389 · see citing works
Finnemann, S. C., Bonilha, V. L., Marmorstein, A. D., & Rodriguez-Boulan, E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.12932 · Cited by 382 · see citing works
Self-citationTHE RENEWAL OF ROD AND CONE OUTER SEGMENTS IN THE RHESUS MONKEY
Young, R. W. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.49.2.303 · Cited by 375 · see citing works
Eliceiri, B. P., Puente, X. S., Hood, J. D., Stupack, D. G., Schlaepfer, D. D., Huang, X., Sheppard, D., & Cheresh, D. A. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200109079 · Cited by 333 · see citing works
Self-citationFinnemann, S. C., Leung, L. W., & Rodriguez-Boulan, E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052025899 · Cited by 283 · see citing works
Self-citationPARTICIPATION OF THE RETINAL PIGMENT EPITHELIUM IN THE ROD OUTER SEGMENT RENEWAL PROCESS
Young, R. W., & Bok, D. (1969) · Journal of Cell Biology · doi:10.1083/jcb.42.2.392 · Cited by 271 · see citing works
An RCS-Like Retinal Dystrophy Phenotype in Mer Knockout Mice
Duncan, J. L., LaVail, M. M., Yasumura, D., Matthes, M. T., Yang, H., Trautmann, N., Chappelow, A. V., Feng, W., Earp, H. S., Matsushima, G. K., et al. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0438 · Cited by 259 · see citing works
Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration.
Holz, F. G., Bellman, C., STAUDT, S., Schütt, F., & Völcker, H. E. (2001) · PubMed · Cited by 242 · see citing works
CD36 participates in the phagocytosis of rod outer segments by retinal pigment epithelium
Ryeom, S. W., Sparrow, J. R., & Silverstein, R. L. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.2.387 · Cited by 230 · see citing works
In Vivo Fundus Autofluorescence in Macular Dystrophies
von Rückmann, A. (1997) · Archives of Ophthalmology · doi:10.1001/archopht.1997.01100150611006 · Cited by 218 · see citing works
Normal Development, Wound Healing, and Adenovirus Susceptibility in β5-Deficient Mice
Huang, X., Griffiths, M., Wu, J., Farese, R. V., & Sheppard, D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.755-759.2000 · Cited by 215 · see citing works
Self-citationFocal adhesion kinase signaling promotes phagocytosis of integrin‐bound photoreceptors
Finnemann, S. C. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg416 · Cited by 208 · see citing works
Self-citationRakoczy, P. E., Zhang, D., Robertson, T., Barnett, N. L., Papadimitriou, J., Constable, I. J., & Lai, C.-M. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64427-6 · Cited by 173 · see citing works
Ezrin Promotes Morphogenesis of Apical Microvilli and Basal Infoldings in Retinal Pigment Epithelium
Bonilha, V. L., Finnemann, S. C., & Rodriguez-Boulan, E. J. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.7.1533 · Cited by 171 · see citing works
Self-citationFinnemann, S. C., & Silverstein, R. L. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.9.1289 · Cited by 154 · see citing works
Self-citationThe daily rhythm of shedding and degradation of cone outer segment membranes in the lizard retina
Young, R. W. (1977) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(77)80084-1 · Cited by 145 · see citing works
Macrophage and Retinal Pigment Epithelium Phagocytosis
Finnemann, S. C., & Rodriguez-Boulan, E. J. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.6.861 · Cited by 144 · see citing works
Self-citationFeeney-Burns, L., & Ge, E. (1983) · PubMed · Cited by 143 · see citing works
Nandrot, E., Dufour, E. M., Provost, A. C., Péquignot, M. O., Bonnel, S., Gogat, K., Marchant, D., Rouillac, C., Sépulchre de Condé, B., Bihoreau, M.-T., et al. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0328 · Cited by 139 · see citing works
Self-citationMiceli, M. V., Newsome, D. A., & Tate, D. J. (1997) · PubMed · Cited by 52 · see citing works
Bayer, A. U., Cook, P., Brodie, S. E., Maag, K.-P., & Mittag, T. W. (2001) · Vision Research · doi:10.1016/s0042-6989(01)00103-1 · Cited by 38 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The Retinal Pigment Epithelium in Visual Function
Strauss, O. (2005) · Physiological Reviews · doi:10.1152/physrev.00021.2004 · Cited by 2,828 · see citing works
The Retinal Pigment Epithelium in Health and Disease
Sparrrow, J. R., Hicks, D., & Hamel, C. (2010) · Current Molecular Medicine · doi:10.2174/156652410793937813 · Cited by 625 · see citing works
Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane
Bevers, E. M., & Williamson, P. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00020.2015 · Cited by 444 · see citing works
Phagocytosis of Retinal Rod and Cone Photoreceptors
Kevany, B. M., & Palczewski, K. (2010) · Physiology · doi:10.1152/physiol.00038.2009 · Cited by 426 · see citing works
The cell biology of the retinal pigment epithelium
Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K., & Williams, D. S. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100846 · Cited by 422 · see citing works
Bachmann, M., Kukkurainen, S., Hytönen, V. P., & Wehrle‐Haller, B. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2018 · Cited by 400 · see citing works
Noncanonical autophagy promotes the visual cycle
Kim, J.-Y., Zhao, H., Martinez, J., Doggett, T. A., Kolesnikov, A. V., Tang, P. H., Ablonczy, Z., Chan, C.-C., Zhou, Z., Green, D. R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.012 · Cited by 347 · see citing works
Hartzell, H. C., Qu, Z., Yu, K., Xiao, Q., & Chien, L. (2008) · Physiological Reviews · doi:10.1152/physrev.00022.2007 · Cited by 349 · see citing works
Phosphatidylserine recognition by phagocytes: a view to a kill
Wu, Y., Tibrewal, N., & Birge, R. B. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.02.003 · Cited by 341 · see citing works
Kaarniranta, K., Sinha, D., Blasiak, J., Kauppinen, A., Veréb, Z., Salminen, A., Boulton, M. E., & Petrovski, G. (2013) · Autophagy · doi:10.4161/auto.24546 · Cited by 326 · see citing works
Transplantation of the RPE in AMD
Binder, S., Stanzel, B. V., Krebs, I., & Glittenberg, C. G. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2007.02.002 · Cited by 292 · see citing works
TAM receptor function in the retinal pigment epithelium
Prasad, D., Rothlin, C. V., Burrola, P., Burstyn-Cohen, T., Lu, Q., Garcia de Frutos, P., & Lemke, G. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.06.011 · Cited by 270 · see citing works
Dynamic Regulation of the Structure and Functions of Integrin Adhesions
Wolfenson, H., Lavelin, I., & Geiger, B. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.02.012 · Cited by 268 · see citing works
Functions and Diseases of the Retinal Pigment Epithelium
Yang, S., Zhou, J. Y., & Li, D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.727870 · Cited by 257 · see citing works
Integrin-dependent phagocytosis – spreading from microadhesion to new concepts
Dupuy, A. G., & Caron, E. (2008) · Journal of Cell Science · doi:10.1242/jcs.018036 · Cited by 245 · see citing works
Immunological Consequences of Apoptotic Cell Phagocytosis
Erwig, L.-P., & Henson, P. M. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070135 · Cited by 242 · see citing works
Essential role for MFG-E8 as ligand for αvβ5 integrin in diurnal retinal phagocytosis
Nandrot, E. F., Anand, M., Almeida, D., Atabai, K., Sheppard, D., & Finnemann, S. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704756104 · Cited by 241 · see citing works
Self-citationUnderstanding photoreceptor outer segment phagocytosis: use and utility of RPE cells in culture
Mazzoni, F., Safa, H., & Finnemann, S. C. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.01.010 · Cited by 221 · see citing works
Self-citationCircadian organization of the mammalian retina: From gene regulation to physiology and diseases
McMahon, D. G., Iuvone, P. M., & Tosini, G. (2013) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2013.12.001 · Cited by 195 · see citing works
SED1/MFG‐E8: A Bi‐Motif protein that orchestrates diverse cellular interactions
Raymond, A. S., Ensslin, M. A., & Shur, B. D. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22076 · Cited by 167 · see citing works
Sun, M., Finnemann, S. C., Febbraio, M., Shan, L., Annangudi, S. P., Podrez, E. A., Hoppe, G., Darrow, R., Organisciak, D. T., Salomon, R. G., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509769200 · Cited by 165 · see citing works
Self-citationRegulation of phagocytosis by Rho GTPases
Mao, Y., & Finnemann, S. C. (2015) · Small GTPases · doi:10.4161/21541248.2014.989785 · Cited by 163 · see citing works
Self-citationRuggiero, L., Connor, M. P., Chen, J., Langen, R., & Finnemann, S. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121101109 · Cited by 156 · see citing works
Self-citationVives-Bauza, C., Anand, M., Shirazi, A. K., Magrane, J., Gao, J., Vollmer-Snarr, H. R., Manfredi, G., & Finnemann, S. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800706200 · Cited by 155 · see citing works
Self-citationInnate apoptotic immunity: the calming touch of death
Birge, R. B., & Ucker, D. S. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.58 · Cited by 154 · see citing works
Samuel, W., Jaworski, C. J., Postnikova, O. A., Kutty, R. K., Duncan, T. E., Tan, L. X., Poliakov, E., Lakkaraju, A., & Redmond, T. M. (2017) · PubMed Central · Cited by 153 · see citing works
Hall, M. O., Obin, M. S., Heeb, M. J., Burgess, B. L., & Abrams, T. A. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.03.017 · Cited by 145 · see citing works
Błasiak, J., Pawłowska, E., Szczepańska, J., & Kaarniranta, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010210 · Cited by 136 · see citing works
Evolving endosomes: how many varieties and why?
Perret, E., Lakkaraju, A., Deborde, S., Schreiner, R. P., & Rodriguez-Boulan, E. J. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.06.008 · Cited by 133 · see citing works
Modulation of three key innate immune pathways for the most common retinal degenerative diseases
Akhtar‐Schäfer, I., Wang, L., Krohne, T. U., Xu, H., & Langmann, T. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708259 · Cited by 127 · see citing works
Gene therapy and genome surgery in the retina
DiCarlo, J. E., Mahajan, V. B., & Tsang, S. H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120429 · Cited by 127 · see citing works
Limbal Epithelial Stem Cells: Role of the Niche Microenvironment
Ordonez, P., & Girolamo, N. D. (2011) · Stem Cells · doi:10.1002/stem.794 · Cited by 127 · see citing works
Biasutto, L., Chiechi, A., Couch, R., Liotta, L. A., & Espina, V. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.05.005 · Cited by 126 · see citing works
Milner, R., Crocker, S. J., Hung, S. Y., Wang, X., Frausto, R. F., & del Zoppo, G. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.8158 · Cited by 123 · see citing works
Roles of the Innate Immune System in Mammary Gland Remodeling During Involution
Atabai, K., Sheppard, D., & Werb, Z. (2007) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-007-9036-6 · Cited by 123 · see citing works
Self-citationSuleiman, L., Négrier, C., & Boukerche, H. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.07.004 · Cited by 120 · see citing works
Eat‐me signals: Keys to molecular phagocyte biology and “Appetite” control
Li, W. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22815 · Cited by 117 · see citing works
Chen, H., Lukas, T. J., Du, N. Y., Suyeoka, G. M., & Neufeld, A. H. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2850 · Cited by 119 · see citing works
Mechanisms for Countering Oxidative Stress and Damage in Retinal Pigment Epithelium
Plafker, S. M., O'Mealey, G. B., & Szweda, L. I. (2012) · International review of cytology · doi:10.1016/b978-0-12-394309-5.00004-3 · Cited by 115 · see citing works
Inana, G., Murat, C., An, W., Yao, X., Harris, I. R., & Cao, J. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1434-6 · Cited by 113 · see citing works
Kaarniranta, K., Kajdanek, J., Morawiec, J., Pawlowska, E., & Blasiak, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082317 · Cited by 112 · see citing works
microRNA expression in the eyes and their significance in relation to functions
Xu, S. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.11.003 · Cited by 110 · see citing works
Isolation, culture and characterization of primary mouse RPE cells
Fernández‐Godino, R., Garland, D. L., & Pierce, E. A. (2016) · Nature Protocols · doi:10.1038/nprot.2016.065 · Cited by 106 · see citing works
Overview: Studying Integrins In Vivo
Lowell, C. A., & Mayadas, T. N. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-166-6_22 · Cited by 104 · see citing works
Tissue engineering of retina through high resolution 3-dimensional inkjet bioprinting
Masaeli, E., Forster, V., Picaud, S. A., Karamali, F., Nasr‐Esfahani, M. H., & Marquette, C. A. (2019) · Biofabrication · doi:10.1088/1758-5090/ab4a20 · Cited by 103 · see citing works
Retinal pigment epithelium polarity in health and blinding diseases
Caceres, P. S., & Rodriguez-Boulan, E. J. (2019) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2019.08.001 · Cited by 101 · see citing works
Bharti, K., den Hollander, A. I., Lakkaraju, A., Sinha, D., Williams, D. S., Finnemann, S. C., Rickman, C. B., Malek, G., & D'Amore, P. A. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109170 · Cited by 92 · see citing works
Self-citationEndogenous transforming growth factor‐beta promotes quiescence of primary microglia in vitro
Spittau, B., Wullkopf, L., Zhou, X., Rilka, J., Pfeifer, D., & KRIEGLSTEIN, K. G. (2012) · Glia · doi:10.1002/glia.22435 · Cited by 91 · see citing works
Ocular Clocks: Adapting Mechanisms for Eye Functions and Health
Felder‐Schmittbuhl, M., Buhr, E. D., Dkhissi‐Benyahya, O., Hicks, D., Peirson, S. N., Ribelayga, C., Sandu, C., Spessert, R., & Tosini, G. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24957 · Cited by 89 · see citing works
The Retina and Other Light-sensitive Ocular Clocks
Besharse, J. C., & McMahon, D. G. (2016) · Journal of Biological Rhythms · doi:10.1177/0748730416642657 · Cited by 90 · see citing works
Chang, Y., & Finnemann, S. C. (2007) · Journal of Cell Science · doi:10.1242/jcs.006361 · Cited by 88 · see citing works
Self-citationGraziotto, J. J., Farkas, M. H., Bujakowska, K. M., Deramaudt, B. M. J. ‐., Zhang, Q., Nandrot, E. F., Inglehearn, C. F., Bhattacharya, S. S., & Pierce, E. A. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5194 · Cited by 86 · see citing works
Self-citationParry, D. A., Toomes, C., Bida, L., Danciger, M., Towns, K. V., McKibbin, M., Jacobson, S. G., Logan, C. V., Ali, M., Bond, J., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.04.005 · Cited by 85 · see citing works
MULTIMODAL FUNDUS IMAGING OF PSEUDOXANTHOMA ELASTICUM
Zweifel, S. A., Imamura, Y., Freund, K. B., & Spaide, R. F. (2010) · Retina · doi:10.1097/iae.0b013e3181f056ce · Cited by 82 · see citing works
Klettner, A., Kauppinen, A., Błasiak, J., Roider, J., Salminen, A., & Kaarniranta, K. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.04.013 · Cited by 80 · see citing works
Mao, Y., & Finnemann, S. C. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0840 · Cited by 80 · see citing works
Self-citationLaw, A.-L., Parinot, C., Chatagnon, J., Gravez, B., Sahel, J., Bhattacharya, S. S., & Nandrot, E. F. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.628297 · Cited by 78 · see citing works
Self-citationSandahl, M. A., Hunter, D. M., Strunk, K. E., Earp, H. S., & Cook, R. S. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-122 · Cited by 79 · see citing works
Farkas, M. H., Lew, D., Sousa, M. E., Bujakowska, K. M., Chatagnon, J., Bhattacharya, S. S., Pierce, E. A., & Nandrot, E. F. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.06.026 · Cited by 79 · see citing works
Self-citationBobu, C., & Hicks, D. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-3145 · Cited by 77 · see citing works
Hove, I. V., Hu, T., Beets, K., Bergen, T. V., Etienne, I., Stitt, A. W., Vermassen, E., & Feyen, J. H. M. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100966 · Cited by 79 · see citing works
Mesenchymal stem cell exosomes as nanotherapeutics for dry age-related macular degeneration
Tang, Y., Kang, Y., Zhang, X., & Cheng, C. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.04.003 · Cited by 76 · see citing works
Annexin A2 regulates phagocytosis of photoreceptor outer segments in the mouse retina
Law, A.-L., Ling, Q., Hajjar, K. A., Futter, C. E., Greenwood, J., Adamson, P., Wavre-Shapton, S. T., Moss, S. E., & Hayes, M. J. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1204 · Cited by 75 · see citing works
Toops, K. A., Tan, L. X., & Lakkaraju, A. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.05.003 · Cited by 73 · see citing works
Novel role for α <sub>v</sub> β <sub>5</sub> -integrin in retinal adhesion and its diurnal peak
Nandrot, E. F., Anand, M., Sircar, M., & Finnemann, S. C. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00480.2005 · Cited by 72 · see citing works
Self-citationAnalysis of Photoreceptor Outer Segment Phagocytosis by RPE Cells in Culture
Mao, Y., & Finnemann, S. C. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-62703-080-9_20 · Cited by 70 · see citing works
Self-citationMertk Activation During RPE Phagocytosis in Vivo Requires αVβ5 Integrin
Finnemann, S. C., & Nandrot, E. F. (2007) · Springer eBooks · doi:10.1007/0-387-32442-9_69 · Cited by 70 · see citing works
Self-citationThe retinal pigment epithelium: Functions and roles in ocular diseases
Wang, S., Li, W., Chen, M., Cao, Y., Lu, W., & Li, X. (2023) · Fundamental Research · doi:10.1016/j.fmre.2023.08.011 · Cited by 69 · see citing works
Zigler, J. S., Zhang, C., Grebe, R. R., Sehrawat, G., Hackler, L., Adhya, S., Hose, S., McLeod, D. S., Bhutto, I. A., Barbour, W., et al. (2011) · Journal of Cell Science · doi:10.1242/jcs.078790 · Cited by 69 · see citing works
MERTK mutation update in inherited retinal diseases
Audo, I. S., Mohand‐Saïd, S., Boulanger-Scemama, É., Zanlonghi, X., Condroyer, C., Démontant, V., Boyard, F., Antonio, A., Méjécase, C., Shamieh, S. E., et al. (2018) · Human Mutation · doi:10.1002/humu.23431 · Cited by 68 · see citing works
Integrins Control Vesicular Trafficking; New Tricks for Old Dogs
Nolte, M. A., Hoen, E. N. M. N., & Margadant, C. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.09.001 · Cited by 66 · see citing works
Grol, J. V., Muniz-Feliciano, L., Portillo, J. C., Bonilha, V. L., & Subauste, C. S. (2013) · Infection and Immunity · doi:10.1128/iai.01145-12 · Cited by 67 · see citing works
Parinot, C., Rieu, Q., Chatagnon, J., Finnemann, S. C., & Nandrot, E. F. (2014) · Journal of Visualized Experiments · doi:10.3791/52100 · Cited by 66 · see citing works
Self-citationStem cells as source for retinal pigment epithelium transplantation
Bertolotti, E., Neri, A., Camparini, M., Macaluso, C., & Marigo, V. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.06.002 · Cited by 66 · see citing works
The role of integrins in glaucoma
Filla, M. S., Faralli, J. A., Peotter, J. L., & Peters, D. M. P. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2016.05.011 · Cited by 66 · see citing works
Clathrin-containing adhesion complexes
Lock, J. G., Baschieri, F., Jones, M., Humphries, J. D., Montagnac, G., Strömblad, S., & Humphries, M. J. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201811160 · Cited by 64 · see citing works
αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells
Acharya, M., Sokolovska, A., Tam, J. M., Conway, K. L., Stefani, C., Raso, F., Mukhopadhyay, S., Feliu, M., Paul, E., Savill, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms10917 · Cited by 62 · see citing works
Müller, C., Charniga, C., Temple, S., & Finnemann, S. C. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.01.017 · Cited by 61 · see citing works
Self-citationScrambled Eggs: Apoptotic Cell Clearance by Non-Professional Phagocytes in the Drosophila Ovary
Serizier, S. B., & McCall, K. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01642 · Cited by 61 · see citing works
Yu, C.-C., Nandrot, E. F., Dun, Y., & Finnemann, S. C. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.021 · Cited by 61 · see citing works
Self-citationWavre-Shapton, S. T., Meschede, I. P., Seabra, M. C., & Futter, C. E. (2014) · Journal of Cell Science · doi:10.1242/jcs.154757 · Cited by 60 · see citing works
TAM receptors in phagocytosis: Beyond the mere internalization of particles
Burstyn‐Cohen, T., & Fresia, R. (2023) · Immunological Reviews · doi:10.1111/imr.13267 · Cited by 58 · see citing works
Anti-integrin therapy for retinovascular diseases
Bhatwadekar, A. D., Kansara, V. S., Luo, Q., & Ciulla, T. A. (2020) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2020.1795639 · Cited by 55 · see citing works
Future Therapies of Wet Age-Related Macular Degeneration
Ishikawa, M., Jin, D., Sawada, Y., Abe, S., & Yoshitomi, T. (2015) · Journal of Ophthalmology · doi:10.1155/2015/138070 · Cited by 54 · see citing works
Characterization of a Spontaneous Mouse Retinal Pigment Epithelial Cell Line B6-RPE07
Chen, M., Muckersie, E., Robertson, M. B., Fraczek, M., Forrester, J. V., & Xu, H. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1522 · Cited by 54 · see citing works
Sethna, S., Chamakkala, T., Gu, X., Thompson, T. C., Cao, G., Elliott, M. H., & Finnemann, S. C. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.687004 · Cited by 53 · see citing works
Self-citationBhoi, J. D., Goel, M., Ribelayga, C., & Mangel, S. C. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101119 · Cited by 51 · see citing works
Won, J., Smith, R. S., Peachey, N. S., WU, J., Hicks, W. L., Naggert, J. Κ., & Nishina, P. M. (2008) · Visual Neuroscience · doi:10.1017/s0952523808080723 · Cited by 53 · see citing works
Nandrot, E. F., Silva, K. E., Scelfo, C., & Finnemann, S. C. (2012) · Biology of the Cell · doi:10.1111/boc.201100076 · Cited by 52 · see citing works
Self-citationThe molecular regulation of organelle transport in mammalian retinal pigment epithelial cells
Futter, C. E. (2006) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00303.x · Cited by 50 · see citing works
Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells
Damek-Poprawa, M., Diemer, T., Lopes, V. S., Lillo, C., Harper, D. C., Marks, M. S., Wu, Y., Sparrow, J. R., Rachel, R. A., Williams, D. S., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808857200 · Cited by 50 · see citing works
174delG Mutation in Mouse MFRP Causes Photoreceptor Degeneration and RPE Atrophy
Fogerty, J., & Besharse, J. C. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8112 · Cited by 50 · see citing works
Endogenous Gas6 and Ca2+-channel activation modulate phagocytosis by retinal pigment epithelium
Karl, M., Kroeger, W., Wimmers, S., Milenkovic, V. M., Valtink, M., Engelmann, K., & Strauß, O. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.02.005 · Cited by 49 · see citing works
Westenskow, P. D., Moreno, S. K., Krohne, T. U., Kurihara, T., Zhu, S., Zhang, Z., Zhao, T., Xu, Y., Ding, S., & Friedlander, M. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-9721 · Cited by 48 · see citing works
Lieffrig, S. A., Gyimesi, G., Mao, Y., & Finnemann, S. C. (2023) · Immunological Reviews · doi:10.1111/imr.13264 · Cited by 47 · see citing works
Self-citationGene Therapy Restores Mfrp and Corrects Axial Eye Length
Velez, G., Tsang, S. H., Tsai, Y.-T., Hsu, C., Gore, A. M., Abdelhakim, A. H., Mahajan, M., Silverman, R. H., Sparrow, J. R., Bassuk, A. G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-16275-8 · Cited by 45 · see citing works
Photoreceptor phagocytosis is mediated by phosphoinositide signaling
Mustafi, D., Kevany, B. M., Genoud, C., Bai, X., & Palczewski, K. (2013) · The FASEB Journal · doi:10.1096/fj.13-237537 · Cited by 44 · see citing works
Biswal, M. R., Ahmed, C. M. I., Ildefonso, C. J., Han, P., Li, H., Jivanji, H., Mao, H., & Lewin, A. S. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.07.022 · Cited by 44 · see citing works
DJ-1-Dependent Regulation of Oxidative Stress in the Retinal Pigment Epithelium (RPE)
Shadrach, K. G., Rayborn, M. E., Hollyfield, J. G., & Bonilha, V. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067983 · Cited by 44 · see citing works
Dopamine 2 Receptor Activation Entrains Circadian Clocks in Mouse Retinal Pigment Epithelium
Baba, K., DeBruyne, J. P., & Tosini, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-05394-x · Cited by 44 · see citing works
- Authors
- Nandrot, E. F., Kim, Y., Brodie, S. E., Huang, X., Sheppard, D., & Finnemann, S. C.
- Affiliations
- 1Margaret M. Dyson Vision Research Institute, Department of Ophthalmology
- Icahn School of Medicine at Mount Sinai (US)
- University of California, San Francisco (US)
- Cornell University (US)
- ORCID
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2004-12-13
- Volume
- 200
- Issue
- 12
- Pages
- 1539-1545
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2211990
- OpenAlex
- W2160550697
- Cited by
- 319
- References
- 33
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 7 · 2023: 15 · 2022: 20 · 2021: 22 · 2020: 21 · 2019: 18 · 2018: 22 · 2017: 19 · 2016: 13 · 2015: 19 · 2014: 17 · 2013: 18 · 2012: 12
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-sa)
- Funders
- National Heart, Lung, and Blood Institute (R37HL053949, HL53949, HL-64353, R01HL064353, R01HL053949)
- National Eye Institute (R01EY013295, EY-13295, EY-14184, R03EY014184)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- retinal pigment epithelium, photoreceptor outer segment phagocytosis, integrin αvβ5, retinal aging, focal adhesions, MERTK
- MeSH terms
- c-Mer Tyrosine Kinase, Aging, Animals, Blindness, Circadian Rhythm, Disease Models, Animal, Phagocytosis, Pigment Epithelium of Eye, Proto-Oncogene Proteins, Signal Transduction, Integrins, Retinal Rod Photoreceptor Cells, Mice, Knockout, Receptors, Vitronectin, Receptor Protein-Tyrosine Kinases, Focal Adhesions, Integrin beta Chains, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
