The DOI matches its Crossref record.
Ryanodine modifies conductance and gating behavior of single Ca2+ release channel
Abstract
Ryanodine affects excitation-contraction coupling in skeletal and cardiac muscle by specifically interacting with the sarcoplasmic reticulum (SR) Ca2+ release channel. The effect of the drug at the single channel level was studied by incorporating skeletal and cardiac SR vesicles into planar lipid bilayers. The two channels were activated by micromolar free Ca2+ and millimolar ATP and inhibited by Mg2+ and ruthenium red. Addition of micromolar concentrations of ryanodine decreased about twofold the unit conductance of the Ca2+- and ATP-activated skeletal and cardiac channels. A second effect of ryanodine was to increase the open probability (Po) of the channels in such a way that Po was close to unity under a variety of activating and inactivating conditions. The effects of ryanodine were long lasting in that removal of ryanodine by perfusion did not return the channels into their fully conducting state.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Coupled Gating Between Individual Skeletal Muscle Ca 2+ Release Channels (Ryanodine Receptors)
Marx, S. O., Ondrias, K., & Marks, A. R. (1998) · Science · doi:10.1126/science.281.5378.818 · Cited by 417
Pieske, B., Sütterlin, M., Schmidt-Schweda, S., Minami, K., Meyer, M., Olschewski, M., Holubarsch, C., Just, H., & Hasenfuss, G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118849 · Cited by 184
Metadata
- Authors
- Rousseau, E., Smith, J. S., & Meissner, G.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1987-09-01
- Volume
- 253
- Issue
- 3
- Pages
- C364-C368
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2188723886
- Cited by
- 551
- References
- 0
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Ryanodine modifies conductance and gating behavior of single Ca2+ release channel. https://app.cochat.ai/papers/10.1152/ajpcell.1987.253.3.c364
- The paper
- Rousseau, E., Smith, J. S., & Meissner, G. (1987). Ryanodine modifies conductance and gating behavior of single Ca2+ release channel. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.1987.253.3.c364
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
