The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Coupled Gating Between Individual Skeletal Muscle Ca 2+ Release Channels (Ryanodine Receptors)
Abstract
Excitation-contraction coupling in skeletal muscle requires the release of intracellular calcium ions (Ca 2+ ) through ryanodine receptor (RyR1) channels in the sarcoplasmic reticulum. Half of the RyR1 channels are activated by voltage-dependent Ca 2+ channels in the plasma membrane. In planar lipid bilayers, RyR1 channels exhibited simultaneous openings and closings, termed “coupled gating.” Addition of the channel accessory protein FKBP12 induced coupled gating, and removal of FKBP12 uncoupled channels. Coupled gating provides a mechanism by which RyR1 channels that are not associated with voltage-dependent Ca 2+ channels can be regulated.
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Cites
Bezprozvanny, L., Watras, J., & Ehrlich, B. E. (1991) · Nature · doi:10.1038/351751a0 · Cited by 1,712
Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands
Schreiber, S. L. (1991) · Science · doi:10.1126/science.1702904 · Cited by 1,494
Purification and reconstitution of the calcium release channel from skeletal muscle
Anthony Lai, F., Erickson, H. P., Rousseau, E., Liu, Q.-Y., & Meissner, G. (1988) · Nature · doi:10.1038/331315a0 · Cited by 941
Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein
Brillantes, A.-M. B., Ondrias, K., Scott, A., Kobrinsky, E., Ondriašová, E., Moschella, M. C., Jayaraman, T., Landers, M., Ehrlich, B. E., & Marks, A. R. (1994) · Cell · doi:10.1016/0092-8674(94)90214-3 · Cited by 827
Self-citationRegions of the skeletal muscle dihydropyridine receptor critical for excitation–contraction coupling
Tanabe, T., Beam, K. G., Adams, B. A., Niidome, T., & Numa, S. (1990) · Nature · doi:10.1038/346567a0 · Cited by 607
Ryanodine modifies conductance and gating behavior of single Ca2+ release channel
Rousseau, E., Smith, J. S., & Meissner, G. (1987) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1987.253.3.c364 · Cited by 551
FK506 binding protein associated with the calcium release channel (ryanodine receptor).
Jayaraman, T., Brillantes, A. M., Timerman, A. P., Fleischer, S., Erdjument-Bromage, H., Tempst, P., & Marks, A. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50114-4 · Cited by 526
Self-citationCardiac defects and altered ryanodine receptor function in mice lacking FKBP12
Shou, W., Aghdasi, B., Armstrong, D. L., Guo, Q., Bao, S., Charng, M.-J., Mathews, L. M., Schneider, M. D., Hamilton, S. L., & Matzuk, M. M. (1998) · Nature · doi:10.1038/35146 · Cited by 431
Regenerative Calcium Release within Muscle Cells
Ford, L. E., & Podolsky, R. J. (1970) · Science · doi:10.1126/science.167.3914.58 · Cited by 391
Ultrastructure of the calcium release channel of sarcoplasmic reticulum.
Saito, A., Inui, M., Radermacher, M., Frank, J., & Fleischer, S. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.1.211 · Cited by 161
Cited by
Inositol Trisphosphate Receptor Ca2+Release Channels
Foskett, J. K., White, C., Cheung, K.-H., & Mak, D.-O. D. (2007) · Physiological Reviews · doi:10.1152/physrev.00035.2006 · Cited by 1,188
Role of β-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease
Lynch, G. S., & Ryall, J. G. (2008) · Physiological Reviews · doi:10.1152/physrev.00028.2007 · Cited by 410
Modulation of the Ryanodine Receptor and Intracellular Calcium
Zalk, R., Lehnart, S. E., & Marks, A. R. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.053105.094237 · Cited by 371
Self-citationSimvastatin triggers mitochondria-induced Ca2+ signaling alteration in skeletal muscle
Sirvent, P., Mercier, J., Vassort, G., & Lacampagne, A. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.070 · Cited by 154
Metadata
- Authors
- Marx, S. O., Ondrias, K., & Marks, A. R.
- Venue
- Science
- Published
- 1998-08-07
- Volume
- 281
- Issue
- 5378
- Pages
- 818-821
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2076384379
- Cited by
- 417
- References
- 12
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Marx, S. O., Ondrias, K., & Marks, A. R. (1998). Coupled Gating Between Individual Skeletal Muscle Ca 2+ Release Channels (Ryanodine Receptors). Science. https://doi.org/10.1126/science.281.5378.818
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
