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Human intestinal glucose transporter expression and localization of GLUT5
Abstract
We have studied the developmental and regional expression of mRNAs encoding sodium-dependent and facilitative glucose transporter proteins in human fetal and adult small intestine. The abundance of mRNAs encoding the Na(+)-glucose cotransporter isoform SGLT1 and the facilitative glucose transporter isoforms GLUT2 and GLUT5 is developmentally modulated with highest levels in adult small intestine. By contrast, the levels of GLUT1 mRNA are higher in fetal than adult small intestine. Immunohistochemical analysis of adult small intestine localized GLUT5 to the luminal surface of mature enterocytes, a finding confirmed by Western blot analysis of purified human jejunal brush-border membranes. By contrast, in the fetal small intestine, GLUT5 was localized along the intercellular junctions of the developing villus, indicating that both its expression and localization are developmentally regulated. The localization of GLUT5 to the luminal surface of mature absorptive epithelial cells implies that this protein participates in the uptake of dietary sugars.
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Citations
Cited by
Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
Wood, I. S., & Trayhurn, P. (2003) · British Journal of Nutrition · doi:10.1079/bjn2002763 · Cited by 889
The glucose transporter family: structure, function and tissue-specific expression
Gould, G. W., & Holman, G. D. (1993) · Biochemical Journal · doi:10.1042/bj2950329 · Cited by 785
Self-citationFunctional Properties and Genomics of Glucose Transporters
Zhao, F.-Q., & Keating, A. (2007) · Current Genomics · doi:10.2174/138920207780368187 · Cited by 549
Insulin receptors and insulin action in the brain: review and clinical implications
Schulingkamp, R. J., Pagano, T. C., Hung, D., & Raffa, R. B. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00040-3 · Cited by 493
Structure and function of mammalian facilitative sugar transporters.
Bell, G. I., Burant, C. F., Takeda, J., & Gould, G. W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36489-0 · Cited by 465
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Metadata
- Authors
- Davidson, N. O., Hausman, A. M., Ifkovits, C. A., Buse, J. B., Gould, G. W., Burant, C. F., & Bell, G. I.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1992-03-01
- Volume
- 262
- Issue
- 3
- Pages
- C795-C800
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2264715249
- Cited by
- 187
- References
- 0
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Davidson, N. O., Hausman, A. M., Ifkovits, C. A., Buse, J. B., Gould, G. W., Burant, C. F., & Bell, G. I. (1992). Human intestinal glucose transporter expression and localization of GLUT5. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.1992.262.3.c795
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