The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
CFTR as a cAMP-Dependent Regulator of Sodium Channels
Abstract
Cystic fibrosis transmembrane regulator (CFTR), the gene product that is mutated in cystic fibrosis (CF) patients, has a well-recognized function as a cyclic adenosine 3′,5′-monophosphate (cAMP)-regulated chloride channel, but this property does not account for the abnormally high basal rate and cAMP sensitivity of sodium ion absorption in CF airway epithelia. Expression of complementary DNAs for rat epithelial Na + channel (rENaC) alone in Madin Darby canine kidney (MDCK) epithelial cells generated large amiloride-sensitive sodium currents that were stimulated by cAMP, whereas coexpression of human CFTR with rENaC generated smaller basal sodium currents that were inhibited by cAMP. Parallel studies that measured regulation of sodium permeability in fibroblasts showed similar results. In CF airway epithelia, the absence of this second function of CFTR as a cAMP-dependent regulator likely accounts for abnormal sodium transport.
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Cites
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Cited by
O'Sullivan, B. P., & Freedman, S. D. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60327-5 · Cited by 1,320
Molecular Structure and Physiological Function of Chloride Channels
Jentsch, T. J., Stein, V., Weinreich, F., & Zdebik, A. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00029.2001 · Cited by 1,256
Mucus clearance as a primary innate defense mechanism for mammalian airways
Knowles, M. R., & Boucher, R. C. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215217 · Cited by 1,054
Self-citationJeffery, C. J. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01335-8 · Cited by 1,016
Inagaki, N., Gonoi, T., Iv, J. P. C., Wang, C.-Z., Aguilar-Bryan, L., Bryan, J., & Seino, S. (1996) · Neuron · doi:10.1016/s0896-6273(00)80124-5 · Cited by 974
Metadata
- Authors
- Stutts, M. J., Canessa, C. M., Olsen, J. C., Hamrick, M., Cohn, J. A., Rossier, B. C., & Boucher, R. C.
- Venue
- Science
- Published
- 1995-08-11
- Volume
- 269
- Issue
- 5225
- Pages
- 847-850
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2019099644
- Cited by
- 1,088
- References
- 1
- FWCI
- 69.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stutts, M. J., Canessa, C. M., Olsen, J. C., Hamrick, M., Cohn, J. A., Rossier, B. C., & Boucher, R. C. (1995). CFTR as a cAMP-Dependent Regulator of Sodium Channels. Science. https://doi.org/10.1126/science.7543698
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
