The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat
Abstract
The molecular pathways for fluid transport in pulmonary, oral, and nasal tissues are still unresolved. Here we use immunocytochemistry and immunoelectron microscopy to define the sites of expression of four aquaporins in the respiratory tract and glandular epithelia, where they reside in distinct, nonoverlapping sites. Aquaporin-1 (AQP1) is present in apical and basolateral membranes of bronchial, tracheal, and nasopharyngeal vascular endothelium and fibroblasts. AQP5 is localized to the apical plasma membrane of type I pneumocytes and the apical plasma membranes of secretory epithelium in upper airway and salivary glands. In contrast, AQP3 is present in basal cells of tracheal and nasopharyngeal epithelium and is abundant in basolateral membranes of surface epithelial cells of nasal conchus. AQP4 resides in basolateral membranes of columnar cells of bronchial, tracheal, and nasopharyngeal epithelium; in nasal conchus AQP4 is restricted to basolateral membranes of a subset of intra- and subepithelial glands. These sites of expression suggest that transalveolar water movement, modulation of airway surface liquid, air humidification, and generation of nasopharyngeal secretions involve a coordinated network of aquaporin water channels.
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Cites
Appearance of Water Channels in Xenopus Oocytes Expressing Red Cell CHIP28 Protein
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Self-citationCloning and expression of apical membrane water channel of rat kidney collecting tubule
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Deen, P. M. T., Verdijk, M. A. J., Knoers, N. V. A. M., Wieringa, B., Monnens, L. A. H., van Os, C. H., & van Oost, B. A. (1994) · Science · doi:10.1126/science.8140421 · Cited by 873
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Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia.
Nielsen, S., Smith, B. L., Christensen, E. I., & Agre, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.7275 · Cited by 781
Self-citationCellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney.
Nielsen, S., DiGiovanni, S. R., Christensen, E. I., Knepper, M. A., & Harris, H. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11663 · Cited by 714
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Self-citationCHIP28 water channels are localized in constitutively water-permeable segments of the nephron.
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Self-citationPathophysiology of the Aquaporin Water Channels
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Cited by
Aquaporin water channels: molecular mechanisms for human diseases1
Agre, P., & Kozono, D. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01083-4 · Cited by 490
Self-citationFunctional requirement of aquaporin-5 in plasma membranes of sweat glands
Nejsum, L. N., Kwon, T.-H., Jensen, U. B., Fumagalli, O., Frøkiaer, J., Krane, C. M., Menon, A. G., King, L. S., Agre, P. C., & Nielsen, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012588099 · Cited by 211
Self-citationBalen, D., Ljubojević, M., Breljak, D., Brzica, H., Z̆lender, V., Koepsell, H., & Sabolić, I. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00180.2008 · Cited by 166
Immunolocalization and translocation of aquaporin-5 water channel in sweat glands
Inoue, R., Sohara, E., Rai, T., Satoh, T., Yokozeki, H., Sasaki, S., & Uchida, S. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.01.013 · Cited by 52
Metadata
- Authors
- Nielsen, S., King, L. S., Christensen, B. M., & Agre, P.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1997-11-01
- Volume
- 273
- Issue
- 5
- Pages
- C1549-C1561
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2171386529
- Cited by
- 426
- References
- 24
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- closed
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