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Pathophysiology of the Aquaporin Water Channels
Abstract
Discovery of aquaporin water channel proteins has provided insight into the molecular mechanism of membrane water permeability. The distribution of known mammalian aquaporins predicts roles in physiology and disease. Aquaporin-1 mediates proximal tubule fluid reabsorption, secretion of aqueous humor and cerebrospinal fluid, and lung water homeostasis. Aquaporin-2 mediates vasopressin-dependent renal collecting duct water permeability; mutations or downregulation can cause nephrogenic diabetes insipidus. Aquaporin-3 in the basolateral membrane of the collecting duct provides an exit pathway for reabsorbed water. Aquaporin-4 is abundant in brain and probably participates in reabsorption of cerebrospinal fluid, osmoregulation, and regulation of brain edema. Aquaporin-5 mediates fluid secretion in salivary and lacrimal glands and is abundant in alveolar epithelium of the lung. Specific regulation of membrane water permeability will likely prove important to understanding edema formation and fluid balance in both normal physiology and disease.
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Cites
Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor
Sibilia, M., & Wagner, E. F. (1995) · Science · doi:10.1126/science.7618085 · Cited by 1,002
Natural History of Sickle Cell Anemia in Saudi Arabs: A Study of 270 Subjects
PERRINE, R. P., PEMBREY, M. E., JOHN, P., PERRINE, S., & SHOUP, F. (1978) · Annals of Internal Medicine · doi:10.7326/0003-4819-88-1-1 · Cited by 284
Cited by
Alveolar epithelial type II cell: defender of the alveolus revisited
Fehrenbach, H. (2001) · Respiratory Research · doi:10.1186/rr36 · Cited by 757
Electrolyte transport in the mammalian colon: mechanisms and implications for disease
Kunzelmann, K., & Mall, M. (2002) · Physiological Reviews · doi:10.1152/physrev.00026.2001 · Cited by 655
Nielsen, S., King, L. S., Christensen, B. M., & Agre, P. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.5.c1549 · Cited by 426
Self-citationSartor, M. A., Tomlinson, C. R., Wesselkamper, S. C., Sivaganesan, S., Leikauf, G. D., & Medvedovic, M. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-538 · Cited by 263
Astrocytes and Glutamine Synthetase in Epileptogenesis
Eid, T., Lee, T. W., Patrylo, P., & Zaveri, H. P. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24267 · Cited by 74
Metadata
- Authors
- King, L. S., & Agre, P.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1996-10
- Volume
- 58
- Issue
- 1
- Pages
- 619-648
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2154312242
- Cited by
- 504
- References
- 2
- FWCI
- 11.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- King, L. S., & Agre, P. (1996). Pathophysiology of the Aquaporin Water Channels. Annual Review of Physiology. https://doi.org/10.1146/annurev.ph.58.030196.003155
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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