The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Skeletal muscle fiber quality in older men and women
Abstract
Whole muscle strength and cross-sectional area (WMCSA), and contractile properties of chemically skinned segments from single fibers of the quadriceps were studied in 7 young men (YM, 36.5 ± 3.0 yr), 12 older men (OM, 74.4 ± 5.9 yr), and 12 older women (OW, 72.1 ± 4.3 yr). WMCSA was smaller in OM compared with YM (56.1 ± 10.1 vs. 79.7 ± 13.1 cm 2; P = 0.031) and in OW (44.9 ± 7.5; P < 0.003) compared with OM. Age-related, but not sex-related, differences in strength were eliminated after adjusting for WMCSA. Maximal force was measured in 552 type I and 230 type IIA fibers. Fibers from YM (type I = 725 ± 221; type IIA = 792 ± 271 μN) were stronger ( P < 0.001) than fibers from OM (I = 505 ± 179; IIA = 577 ± 262 μN) even after correcting for size. Type IIA fibers were stronger ( P < 0.005) than type I fibers in YM and OM but not in OW (I = 472 ± 154; IIA = 422 ± 97 μN). Sex-related differences in type I and IIA fibers were dependent on fiber size. In conclusion, differences in WMCSA explain age-related differences in strength. An intrinsic defect in contractile proteins could explain weakness in single fibers from OM. Sex-related differences exist at the whole muscle and single fiber levels.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Standard Errors and Sample Sizes for Two-Level Research
Snijders, T. A. B., & Bosker, R. J. (1993) · Journal of Educational Statistics · doi:10.3102/10769986018003237 · Cited by 487
Cited by
Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797
Skeletal muscle: A brief review of structure and function
Frontera, W. R., & Ochala, J. (2015) · Calcified Tissue International · doi:10.1007/s00223-014-9915-y · Cited by 1,758
Self-citationInvited Review: Aging and sarcopenia
Doherty, T. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00347.2003 · Cited by 1,764
Fragala, M. S., Cadore, E. L., Dorgo, S., Izquierdo, M., Kraemer, W. J., Peterson, M. D., & Ryan, E. D. (2019) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003230 · Cited by 1,290
Effects of Aging on Muscle Fibre Type and Size
Deschenes, M. R. (2004) · Sports Medicine · doi:10.2165/00007256-200434120-00002 · Cited by 671
Metadata
- Authors
- Frontera, W. R., Suh, D., Krivickas, L. S., Hughes, V. A., Goldstein, R., & Roubenoff, R.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2000-09-01
- Volume
- 279
- Issue
- 3
- Pages
- C611-C618
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W148671107
- Cited by
- 424
- References
- 1
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Skeletal muscle fiber quality in older men and women. https://app.cochat.ai/papers/10.1152/ajpcell.2000.279.3.c611
- The paper
- Frontera, W. R., Suh, D., Krivickas, L. S., Hughes, V. A., Goldstein, R., & Roubenoff, R. (2000). Skeletal muscle fiber quality in older men and women. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.2000.279.3.c611
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
