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Skeletal muscle fiber quality in older men and women
Abstract
Whole muscle strength and cross-sectional area (WMCSA), and contractile properties of chemically skinned segments from single fibers of the quadriceps were studied in 7 young men (YM, 36.5 ± 3.0 yr), 12 older men (OM, 74.4 ± 5.9 yr), and 12 older women (OW, 72.1 ± 4.3 yr). WMCSA was smaller in OM compared with YM (56.1 ± 10.1 vs. 79.7 ± 13.1 cm 2; P = 0.031) and in OW (44.9 ± 7.5; P < 0.003) compared with OM. Age-related, but not sex-related, differences in strength were eliminated after adjusting for WMCSA. Maximal force was measured in 552 type I and 230 type IIA fibers. Fibers from YM (type I = 725 ± 221; type IIA = 792 ± 271 μN) were stronger ( P < 0.001) than fibers from OM (I = 505 ± 179; IIA = 577 ± 262 μN) even after correcting for size. Type IIA fibers were stronger ( P < 0.005) than type I fibers in YM and OM but not in OW (I = 472 ± 154; IIA = 422 ± 97 μN). Sex-related differences in type I and IIA fibers were dependent on fiber size. In conclusion, differences in WMCSA explain age-related differences in strength. An intrinsic defect in contractile proteins could explain weakness in single fibers from OM. Sex-related differences exist at the whole muscle and single fiber levels.
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Metadata
- Authors
- Frontera, W. R., Suh, D., Krivickas, L. S., Hughes, V. A., Goldstein, R., & Roubenoff, R.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2000-09-01
- Volume
- 279
- Issue
- 3
- Pages
- C611-C618
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W148671107
- Cited by
- 424
- References
- 1
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
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