The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Effect of antioxidant protection by p-coumaric acid on low-density lipoprotein cholesterol oxidation
Abstract
Mechanisms in which p-coumaric acid (CA) acts as an antioxidant are not well understood. This study investigated whether CA can act as a direct scavenger of reactive oxygen species (ROS) and whether it minimizes the oxidation of low-density lipoprotein (LDL). Rats were administered CA in drinking water at low or high doses for 10, 21, and 30 days (uptakes were 29 and 317 mg/day, respectively). Blood levels of 8-epiprostaglandin F 2α were monitored as a marker of LDL oxidation. Oral administration of CA (317 mg/day) for 30 days significantly inhibited LDL oxidation. CA also reduced LDL cholesterol levels in serum but had no effect on levels of high-density lipoprotein cholesterol. In vitro studies that used electron spin resonance in combination with spin trapping techniques were used to determine the ability of CA to scavenge ROS and alter LDL oxidation. CA effectively scavenged ·OH in a dose-dependent manner. IC 50 and maximum velocity for CA scavenging of ·OH were 4.72 μM and 1.2 μM/s, respectively, with a rate constant of 1.8 × 10 11 M−1 · s−1. Our studies suggest that the antioxidant properties of CA may involve the direct scavenging of ROS such as ·OH.
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“p-coumaric acid, which was detected at the level of 23.96 mg/kg in LC-MS/MS analysis, has been reported to be a relatively strong antioxidant and a scavenger of reactive oxygen species and other free radicals41,42.”
From Synergistic and antagonistic contributions of main components to the bioactivity profile of Anethum graveolens extract (2025) · cites this paper as [41]
In the citing paper
“Among the phenolics in the extract, rutin, caffeic acid and p-coumaric acid are important antioxidants and act by scavenging free radicals41,42.”
From Synergistic and antagonistic contributions of main components to the bioactivity profile of Anethum graveolens extract (2025) · cites this paper as [41]
Citations
Cites
LXXIII.—Oxidation of tartaric acid in presence of iron
Fenton, H. J. H. (1894) · J. Chem. Soc., Trans. · doi:10.1039/ct8946500899 · Cited by 3,179
Retsky, K. L., Freeman, M. W., & Frei, B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54075-8 · Cited by 271
Research works printed but not linked: 28
- 10.1111/j.1751-1097.1986.tb03556.x · DOI
- 10.1042/bj3160691 · DOI
- 10.1016/0014-5793(95)00639-Q · DOI
- 10.1021/ja00535a029 · DOI
- 10.1021/ja00854a045 · DOI
- 10.1073/pnas.85.24.9748 · DOI
- 10.1042/bj1630441 · DOI
- 10.1042/bj1530513a · DOI
- 10.1016/0006-2952(95)02171-X · DOI
- 10.1006/abbi.1995.0057 · DOI
- 10.1073/pnas.89.19.9230 · DOI
- 10.1006/bbrc.1995.1318 · DOI
- 10.1073/pnas.89.22.10721 · DOI
- 10.1016/0003-2697(90)90002-Q · DOI
- 10.1073/pnas.87.23.9383 · DOI
- 10.1016/0891-5849(91)90076-F · DOI
- 10.1016/S0021-9150(97)00124-X · DOI
- 10.1016/S0008-6363(96)00237-4 · DOI
- 10.1007/BF02533528 · DOI
- 10.1002/clc.4960141302 · DOI
- Shi X, 1997, Ann Clin Lab Sci, 27, 365
- 10.1248/bpb.16.434 · DOI
- 10.1016/S0009-9120(67)80002-X · DOI
- 10.1093/clinchem/24.6.900 · DOI
- 10.1016/S0304-4165(98)00099-3 · DOI
- 10.1016/S0021-9258(19)85448-0 · DOI
- 10.1016/0891-5849(94)00236-D · DOI
- Zang LY, 1995, Biochem Mol Biol Int, 37, 283
Cited by
Shen, Y., Song, X., Li, L., Sun, J., Jaiswal, Y., Huang, J., Liu, C., Yang, W., Williams, L., Zhang, H., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.074 · Cited by 206
Kesti Usta, S., Yalçın, E., & Çavuşoğlu, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-07297-8 · Cited by 10
Metadata
- Authors
- Zang, L.-Y., Cosma, G., Gardner, H., Shi, X., Castranova, V., & Vallyathan, V.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2000-10-01
- Volume
- 279
- Issue
- 4
- Pages
- C954-C960
- ISSN
- 0363-6143
- 1522-1563
- Cited by
- 160
- References
- 2
- Language
- en
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- Zang, L.-Y., Cosma, G., Gardner, H., Shi, X., Castranova, V., & Vallyathan, V. (2000). Effect of antioxidant protection by p-coumaric acid on low-density lipoprotein cholesterol oxidation. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.2000.279.4.c954
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
