Cited by 298Adipose Tissue and MetabolismPeroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Metabolic and cellular plasticity in white adipose tissue I: effects of β3-adrenergic receptor activation

Granneman, James G., Li, Pipeng, Zhu, Zhengxian, Lu, Yuyan·2005·American Journal of Physiology-Endocrinology and Metabolism

Abstract

Selective agonists of β 3-adrenergic receptors (Adrb3) exhibit potent anti-diabetes properties in rodent models when given chronically, yet the mechanisms involved are poorly understood. A salient feature of chronic Adrb3 activation is pronounced remodeling of white adipose tissue (WAT), which includes mitochondrial biogenesis and elevation of metabolic rate. To gain insights into potential mechanisms underlying WAT remodeling, the time course of remodeling induced by the Adrb3 agonist CL-316,243 (CL) was analyzed using histological, physiological, and global gene profiling approaches. The results indicate that continuous CL treatment induced a transient proinflammatory response that was followed by cellular proliferation among stromal cells and multilocular adipoctyes. CL treatment strongly fragmented the central lipid storage droplet of mature adipocytes and induced mitochondrial biogenesis within these cells. Mitochondrial biogenesis was correlated with the upregulation of genes involved in fatty acid oxidation and mitochondrial electron transport activity. The elevated catabolic activity of WAT was temporally correlated with upregulation of peroxisome proliferator-activated receptor-α and its target genes, suggesting involvement of this transcription factor in coordinating the gene program that elevates WAT catabolic activity.

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Crossref · 10.1152/ajpendo.00009.2005

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46 of 46 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Granneman, J. G., Li, P., Zhu, Z., & Lu, Y.
Affiliations
Wayne State University (US)
Venue
American Journal of Physiology-Endocrinology and Metabolism
Published
2005-10
Volume
289
Issue
4
Pages
E608-E616
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
OpenAlex
W1981281539
Cited by
298
References
46
Citations by year
2026: 8 · 2025: 7 · 2024: 9 · 2023: 11 · 2022: 6 · 2021: 14 · 2020: 11 · 2019: 17 · 2018: 12 · 2017: 15 · 2016: 23 · 2015: 22 · 2014: 28 · 2013: 26 · 2012: 21
FWCI
5.99
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r21dk066505-02)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 062292, DK 066505)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
beta3-adrenergic receptor, white adipose tissue remodeling, CL316,243, mitochondrial biogenesis, adipocyte lipolysis, fatty acid oxidation, PPARα, adipocyte inflammation, adipocyte proliferation, metabolic rate, anti-diabetic effects, adipocyte gene expression
MeSH terms
Adaptation, Physiological, Adipose Tissue, Animals, Dioxoles, Energy Metabolism, Male, Mice, Inbred C57BL, Mitochondria, Gene Expression Profiling, Receptors, Adrenergic, beta-3, Cell Size, Cell Proliferation, Mice, Adrenergic beta-3 Receptor Agonists

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