Effect of fatty acids on energy coupling processes in mitochondria

Wojtczak, Lech; Schönfeld, Peter

doi:10.1016/0005-2728(93)90004-y

Cited by 363Mitochondrial Function and PathologyAdipose Tissue and MetabolismATP Synthase and ATPases Research

Effect of fatty acids on energy coupling processes in mitochondria

Wojtczak, Lech, Schönfeld, Peter·1993·Biochimica et Biophysica Acta (BBA) - Bioenergetics

DOI 10.1016/0005-2728(93)90004-y

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Abstract

Long-chain fatty acids are natural uncouplers of oxidative phosphorylation in mitochondria. The protonophoric mechanism of this action is due to transbilayer movement of undissociated fatty acid in one direction and the passage of its anion in the opposite direction. The transfer of the dissociated form of fatty acid can be, at least in some kinds of mitochondrion, facilitated by adenine nucleotide translocase. Apart from dissipating the electrochemical proton gradient, long-chain fatty acids decrease the activity of the respiratory chain by mechanism(s) not fully understood. In intact cells and tissues fatty acids operate mostly as excellent respiratory substrates, providing electrons to the respiratory chain. This function masks their potential uncoupling effect which becomes apparent only under special physiological or pathological conditions characterized by unusual fatty acid accumulation. Short- and medium-chain fatty acids do not have protonophoric properties. Nevertheless, they contribute to energy dissipation because of slow intramitochondrial hydrolysis of their activation products, acyl-AMP and acyl-CoA. Long-chain fatty acids increase permeability of mitochondrial membranes to alkali metal cations. This is due to their ionophoric mechanism of action. Regulatory function of fatty acids with respect to specific cation channels has been postulated for the plasma membrane of muscle cells, but not demonstrated in mitochondria. Under cold stress, cold acclimation and arousal from hibernation the uncoupling effect of fatty acids may contribute to increased thermogenesis, especially in the muscle tissue. In brown adipose tissue, the special thermogenic organ of mammals, long-chain fatty acids promote operation of the unique natural uncoupling protein, thermogenin. As anionic amphiphiles, long-chain fatty acids increase the negative surface charge of biomembranes, thus interfering in their enzymic and transporting functions.

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FFAs are a required co-factor for UCP-1-catalyzed proton transport.
“Experiments performed on liposomes enriched in UCP-1 showed that FFAs are a required co-factor for UCP-1-catalyzed proton transport [29]”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [29]
FFAs stimulate mitochondrial respiration directly, as seen in intact isolated brown adipocytes or mitochondria isolated from these cells.
“First, they stimulate directly mitochondrial respiration, as seen in intact isolated brown adipocytes or mitochondria isolated from these cells [28,29].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [29]

Thermogenic mechanisms in brown fat.
Nicholls, D. G., & Locke, R. M. (1984) · Physiological Reviews · doi:10.1152/physrev.1984.64.1.1 · Cited by 1,602 · see citing works
The Interaction of Human Serum Albumin with Long-chain Fatty Acid Anions
Goodman, D. S. (1958) · Journal of the American Chemical Society · doi:10.1021/ja01548a024 · Cited by 766 · see citing works
ATP-sensitive K+ channel in the mitochondrial inner membrane
Inoue, I., Nagase, H., Kishi, K., & Higuti, T. (1991) · Nature · doi:10.1038/352244a0 · Cited by 751 · see citing works
The Influence of Respiration and ATP Hydrolysis on the Proton‐Electrochemical Gradient across the Inner Membrane of Rat‐Liver Mitochondria as Determined by Ion Distribution
Nicholls, D. G. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03899.x · Cited by 720 · see citing works
Effect of surface active agents on the latent ATPASE of mitochondira
Pressman, B. C., & Lardy, H. A. (1956) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(56)90182-2 · Cited by 478 · see citing works
Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation
Skulachev, V. P. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80658-p · Cited by 467 · see citing works
Adenine Nucleotide Translocation of Mitochondria
Pfaff, E., & Klingenberg, M. (1968) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1968.tb00420.x · Cited by 425 · see citing works
Direct regulation of ion channels by fatty acids
Ordway, R. W., Singer, J. J., & Walsh, J. V. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90069-7 · Cited by 408 · see citing works
The Optimal Efficiency and the Economic Degrees of Coupling of Oxidative Phosphorylation
Stucki, J. W. (1980) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1980.tb04792.x · Cited by 401 · see citing works
Transport of protons across membranes by weak acids.
McLaughlin, S., & Dilger, J. P. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.3.825 · Cited by 400 · see citing works
Brown adipose tissue mitochondria
Nicholls, D. G. (1979) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(79)90016-8 · Cited by 369 · see citing works
The uncoupling protein from brown fat mitochondria is related to the mitochondrial ADP/ATP carrier. Analysis of sequence homologies and of folding of the protein in the membrane.
Aquila, H., Link, T. A., & Klingenberg, M. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03941.x · Cited by 368 · see citing works
Reconstitution and partial purification of the glibenclamide-sensitive, ATP-dependent K+ channel from rat liver and beef heart mitochondria.
Pauček, P., Mironova, G. D., Mahdi, F., Beavis, A. D., Woldegiorgis, G., & Garlid, K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35717-x · Cited by 357 · see citing works
Reversible Inhibition of Mitochondrial Adenosine Diphosphate Phosphorylation by Long Chain Acyl Coenzyme A Esters
Pande, S. V., & Blanchaer, M. C. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62505-0 · Cited by 355 · see citing works
Arachidonic Acid and Other Fatty Acids Directly Activate Potassium Channels in Smooth Muscle Cells
Ordway, R. W., Walsh, J. V., & Singer, J. J. (1989) · Science · doi:10.1126/science.2471269 · Cited by 350 · see citing works
Function and molecular aspects of biomembrane transport
Kenny, J. M. (1981) · Biochemical Education · doi:10.1016/0307-4412(81)90071-6 · Cited by 333 · see citing works
Potassium Channels in Cardiac Cells Activated by Arachidonic Acid and Phospholipids
Kim, D. H., & Clapham, D. E. (1989) · Science · doi:10.1126/science.2727703 · Cited by 331 · see citing works
The interaction of highly active uncouplers with mitochondria
Terada, H. (1981) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(81)90011-2 · Cited by 313 · see citing works
Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications.
Shinomura, T., Asaoka, Y., Oka, M., Yoshida, K., & Nishizuka, Y. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.12.5149 · Cited by 309 · see citing works
The biochemistry of an inefficient tissue: brown adipose tissue.
Cannon, B., & Nedergaard, J. (1985) · PubMed · Cited by 309 · see citing works
Uncoupling activity of long-chian fatty acids
Borst, P., Loos, J. A., Christ, E., & Slater, E. C. (1962) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(62)90232-9 · Cited by 308 · see citing works
The ATP/ADP‐antiporter is involved in the uncoupling effect of fatty acids on mitochondria
Andreyev, A. Y., BONDAREVA, T. O., Dedukhova, V. I., MOKHOVA, E. N., Skulachev, V. P., TSOFINA, L. M., Волков, Н. И., & VYGODINA, T. V. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb14867.x · Cited by 302 · see citing works
pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids.
Kamp, F., & Hamilton, J. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11367 · Cited by 299 · see citing works
The uncoupling protein ucp: A membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue
Klaus, S., Casteilla, L., Bouillaud, F., & Ricquier, D. (1991) · International Journal of Biochemistry · doi:10.1016/0020-711x(91)90062-r · Cited by 286 · see citing works
An Endogenous Uncoupling and Swelling Agent in Liver Mitochondria and Its Enzymic Formation
Lehninger, A. L., & Remmert, L. F. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69835-7 · Cited by 269 · see citing works
Mechanism and evolution of the uncoupling protein of brown adipose tissue
Klingenberg, M. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90194-g · Cited by 267 · see citing works
Uncoupling of oxidative phosphorylation
Hanstein, W. G. (1976) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(76)90010-0 · Cited by 262 · see citing works
Organ and subcellular distribution of fatty acid activating enzymes in the rat
Aas, M. (1971) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(71)90253-0 · Cited by 256 · see citing works
Monocarboxylic acid permeation through lipid bilayer membranes
Walter, A., & Gutknecht, J. (1984) · The Journal of Membrane Biology · doi:10.1007/bf01870573 · Cited by 235 · see citing works
Adenine Nucleotide Translocation of Mitochondria. Kinetics of the Adenine Nucleotide Exchange
Pfaff, E., Heldt, H. W., & Klingenberg, M. (1969) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1969.tb00715.x · Cited by 226 · see citing works
Formation and disappearance of an endogenous uncoupling factor during swelling and contraction of mitochondria
Wojtczak, L., & Lehninger, A. L. (1961) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(61)90600-x · Cited by 226 · see citing works
Self-citation
Solute carriers involved in energy transfer of mitochondria form a homologous protein family
Aquila, H., Link, T. A., & Klingenberg, M. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)81546-6 · Cited by 222 · see citing works
Membrane potential and surface potential in mitochondria: Uptake and binding of lipophilic cations
Rottenberg, H. (1984) · The Journal of Membrane Biology · doi:10.1007/bf01868977 · Cited by 218 · see citing works
Hamster Brown‐Adipose‐Tissue Mitochondria
Nicholls, D. G. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03861.x · Cited by 217 · see citing works
Control of mitochondrial respiration
Tager, J. M., Wanders, R. J. A., Groen, A. K., Kunz, W. S., Bohnensack, R., Küster, U., Letko, G., Böhme, G., Duszyński, J., & Wojtczak, L. (1983) · FEBS Letters · doi:10.1016/0014-5793(83)80330-5 · Cited by 213 · see citing works
Self-citation
Mitochondria : structure and function
Ernster, L., & Drahota, Z. (1969) · Academic Press eBooks · Cited by 210 · see citing works
A minimal hypothesis for membrane-linked free-energy transduction
Westerhoff, H. V., Melandri, B. A., Venturoli, G., AZZONE, G. F., & Kell, D. B. (1984) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(84)90019-3 · Cited by 207 · see citing works
Both membrane stretch and fatty acids directly activate large conductance Ca2+‐activated K+ channels in vascular smooth muscle cells
Kirber, M. T., Ordway, R. W., Clapp, L. H., Walsh, J. V., & Singer, J. J. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80319-c · Cited by 202 · see citing works
Molecular Mechanisms in Bioenergetics
Šiffel, P. (1996) · Biologia Plantarum · doi:10.1007/bf02890602 · Cited by 201 · see citing works
Adenine Nucleotide Translocation of Mitochondria
Weidemann, M. J., Erdelt, H., & Klingenberg, M. (1970) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1970.tb01086.x · Cited by 197 · see citing works
Brown‐adipose‐tissue mitochondria: the regulation of the 32 000‐Mr uncoupling protein by fatty acids and purine nucleotides
Rial, E., POUSTIE, A., & Nicholls, D. G. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07815.x · Cited by 186 · see citing works
Fully delocalised chemiosmotic or localised proton flow pathways in energy coupling?
Ferguson, S. J. (1985) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(85)90005-9 · Cited by 176 · see citing works
Reversible Inhibition of Adenine Nucleotide Translocation by Long Chain Fatty Acyl Coenzyme A Esters in Liver Mitochondria of Diabetic and Hibernating Animals
Lerner, E., Shug, A. L., Elson, C. E., & Shrago, E. S. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45587-7 · Cited by 172 · see citing works
The reconstituted isolated uncoupling protein is a membrane potential driven H+ translocator.
Klingenberg, M., & Winkler, E. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb04049.x · Cited by 170 · see citing works
Slip and leak in mitochondrial oxidative phosphorylation
Murphy, M. P. (1989) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(89)80063-5 · Cited by 170 · see citing works
Surface Charge of Biological Membranes as a Possible Regulator of Membrane‐Bound Enzymes
Wojtczak, L., & Nałȩcz, M. J. (1979) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1979.tb12876.x · Cited by 167 · see citing works
Self-citation
Effect of long-chain fatty acids and acyl-CoA on mitochondrial permeability, transport, and energy-coupling processes
Wojtczak, L. (1976) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00765158 · Cited by 163 · see citing works
Self-citation
Fatty Acids as Acute Regulators of the Proton Conductance of Hamster Brown‐Fat Mitochondria
LOCKE, R. M., Rial, E., SCOTT, I. D., & Nicholls, D. G. (1982) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1982.tb07060.x · Cited by 150 · see citing works
Carboxyatractylate inhibits the uncoupling effect of free fatty acids
Andreyev, A. Y., BONDAREVA, T. O., Dedukhova, V. I., MOKHOVA, E. N., Skulachev, V. P., & Волков, Н. И. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)81436-4 · Cited by 149 · see citing works
Short-chain fatty acid activation in rat liver a new assay procedure for the enzymes and studies on their intracellular localization
Aas, M., & Bremer, J. (1968) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(68)90142-2 · Cited by 139 · see citing works
Proton conductance caused by long-chain fatty acids in phospholipid bilayer membranes
Gutknecht, J. (1988) · The Journal of Membrane Biology · doi:10.1007/bf01871769 · Cited by 138 · see citing works
Brown adipose tissue mitochondria
Flatmark, T., & Pedersen, J. I. (1975) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(75)90013-0 · Cited by 132 · see citing works
The nature and mechanism of action of uncoupling agents present in mitochrome preparations
Hülsmann, W. C., Elliott, W. B., & Slater, E. C. (1960) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(60)90163-3 · Cited by 130 · see citing works
An appraisal of the functional significance of the inhibitory effect of long chain acyl‐CoAs on mitochondrial transports
Morel, F., Lauquin, G. J. ‐., Lunardi, J., Duszyński, J., & Vignais, P. V. (1974) · FEBS Letters · doi:10.1016/0014-5793(74)80035-9 · Cited by 123 · see citing works
The regulation of the oxidation of fatty acids and other substrates in rat heart mitochondria by changes in the matrix volume induced by osmotic strength, valinomycin and Ca2+
Halestrap, A. P. (1987) · Biochemical Journal · doi:10.1042/bj2440159 · Cited by 123 · see citing works
Interconversion of pyruvate dehydrogenase in rat heart muscle upon perfusion with fatty acids or ketone bodies
WIELAND, O. H., Funcke, H. J. V., & Löffler, G. (1971) · FEBS Letters · doi:10.1016/0014-5793(71)80641-5 · Cited by 122 · see citing works
Fatty acid uncoupling of oxidative phosphorylation in rat liver mitochondria.
Rottenberg, H., & Hashimoto, K. (1986) · Biochemistry · doi:10.1021/bi00355a045 · Cited by 120 · see citing works
On the nature of ion leaks in energy-transducing membranes
Garlid, K., Beavis, A. D., & Kjelstrup, S. (1989) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(89)80219-1 · Cited by 117 · see citing works
Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate.
Khan, W. A., Blobe, G. C., & Hannun, Y. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50567-1 · Cited by 114 · see citing works
Mitochondrien aus braunem Fettgewebe: Entkopplung der Atmungskettenphosphorylierung durch langkettige Fettsäuren und Rekopplung durch Guanosintriphosphat
Rafael, J., Ludolph, H. J., Hohorst, H. J., & GARMANN, W. (1969) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1969.350.2.1121 · Cited by 114 · see citing works
The inhibition of translocation of adenine nucleotides through mitochondrial membranes by oleate
Wojtczak, L., & Załuska, H. (1967) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(67)90409-3 · Cited by 109 · see citing works
Self-citation
Mechanism of action of agents which uncouple oxidative phosphorylation: Direct correlation between protoncarrying and respiratory-releasing properties using rat liver mitochondria
Cunarro, J. A., & Weiner, M. W. (1975) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(75)90106-1 · Cited by 108 · see citing works
Brain Free Fatty Acids, Edema, and Mortality in Gerbils Subjected to Transient, Bilateral Ischemia, and Effect of Barbiturate Anesthesia
Yoshida, S., Inoh, S., Asano, T., Sano, K., Shimasaki, H., & Ueta, N. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb13567.x · Cited by 107 · see citing works
Changes in permeability to protons and other cations at high proton motive force in rat liver mitochondria
Brown, G. C., & Brand, M. D. (1986) · Biochemical Journal · doi:10.1042/bj2340075 · Cited by 107 · see citing works
INFLUENCE OF POTASSIUM AND OTHER ALKALI CATIONS ON RESPIRATION OF MITOCHONDRIA
Pressman, B. C., & Lardy, H. A. (1952) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55609-x · Cited by 106 · see citing works
New substrates and competitive inhibitors of the Cl- translocating pathway of the uncoupling protein of brown adipose tissue mitochondria.
Ježek, P., & Garlid, K. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30658-0 · Cited by 105 · see citing works
Uncoupling of oxidative phosphorylation. 1. Protonophoric effects account only partially for uncoupling
Luvisetto, S., Pietrobon, D., & AZZONE, G. F. (1987) · Biochemistry · doi:10.1021/bi00397a021 · Cited by 105 · see citing works
The effects of valproate on intermediary metabolism in isolated rat hepatocytes and intact rats
Turnbull, D. M., Bone, A. J., Bartlett, K., Koundakjian, P. P., & Sherratt, H. S. A. (1983) · Biochemical Pharmacology · doi:10.1016/0006-2952(83)90054-0 · Cited by 103 · see citing works
STUDIES ON THE INITIAL STEP OF FATTY ACID ACTIVATION
Jencks, W. P., & Lipmann, F. A. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64923-3 · Cited by 102 · see citing works
Uncoupling of oxidative phosphorylation and inhibition of ATPPi exchange by a substance from insect mitochondria
Wojtczak, L., & Wojtczak, A. (1960) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(60)90164-5 · Cited by 100 · see citing works
Self-citation
The role of fatty acids in mitochondrial changes during liver ischemia
Boime, I., Smith, E. E., & Hunter, F. E. (1970) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(70)90496-0 · Cited by 98 · see citing works
A combined light and electron microscope study of early anoxic-ischaemic cell change in rat brain
McGee-Russell, S. M., Brown, A. W., & Brierley, J. B. (1970) · Brain Research · doi:10.1016/0006-8993(70)90288-x · Cited by 97 · see citing works
Does the function of adenine nucleotide translocase in fatty acid uncoupling depend on the type of mitochondria?
Schönfeld, P. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80259-l · Cited by 96 · see citing works
Self-citation
Coordinate control of intermediary metabolism in rat liver by the insulin/glucagon ratio during starvation and after glucose refeeding
Seitz, H. J., Müller, M. J., Krone, W., & Tarnowski, W. (1977) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(77)90399-x · Cited by 94 · see citing works
Interconversion of Pyruvate Dehydrogenase in the Isolated Perfused Rat Liver
Patzelt, C., Löffler, G., & WIELAND, O. H. (1973) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1973.tb02662.x · Cited by 94 · see citing works
Diagnostic value of orotic acid excretion in heritable disorders of the urea cycle and in hyperammonemia due to organic acidurias
Bachmann, C., & Colombo, J. P. (1980) · European Journal of Pediatrics · doi:10.1007/bf01846026 · Cited by 92 · see citing works
A Novel mechanism for inhibition of β‐oxidation by methylenecyclopropylacetyl‐CoA, a metabolite of hypoglycin
Osmundsen, H., & Sherratt, H. S. A. (1975) · FEBS Letters · doi:10.1016/0014-5793(75)80951-3 · Cited by 91 · see citing works
A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria.
Alexson, S. E. H., & Nedergaard, J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68279-1 · Cited by 89 · see citing works
Biphasic Liberation of Arachidonic and Stearic Acids During Cerebral Ischemia
Yasuda, H., Kishiro, K., Izumi, N., & Nakanishi, M. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb05489.x · Cited by 89 · see citing works
Decoupling of oxidative phosphorylation and photophosphorylation
Rottenberg, H. (1990) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(90)90103-b · Cited by 89 · see citing works
Inhibition of medium-chain fatty acid β-oxidationinvitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentenoic acid
Bjorge, S. M., & Baillie, T. A. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)91014-9 · Cited by 85 · see citing works
A possible mechanism of mitochondrial dysfunction during cerebral ischemia: Inhibition of mitochondrial respiration activity by arachidonic acid
Takeuchi, Y., Morii, H., Tamura, M., Hayaishi, O., & Watanabe, Y. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90438-o · Cited by 85 · see citing works
On the mechanism of A23187-induced potassium efflux in rat liver mitochondria.
Dordick, R. S., Brierley, G. P., & Garlid, K. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70464-5 · Cited by 83 · see citing works
Fatty acid activation of the reconstituted brown adipose tissue mitochondria uncoupling protein
Strieleman, P. J., Schalinske, K. L., & Shrago, E. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38735-5 · Cited by 82 · see citing works
Metabolism of Isolated Kidney Tubules
Guder, W., WIELAND, O. H., & Stukowski, B. (1972) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1972.tb02502.x · Cited by 82 · see citing works
Mechanisms of the metabolic disturbances caused by hypoglycin and by pent-4-enoic acid in vitro studies
Billington, D. C., Osmundsen, H., & Sherratt, H. S. A. (1978) · Biochemical Pharmacology · doi:10.1016/0006-2952(78)90204-6 · Cited by 81 · see citing works
The mechanism of stimulation of respiration by fatty acids in isolated hepatocytes.
Nobes, C. D., Hay, W. W., & Brand, M. D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38246-8 · Cited by 80 · see citing works
Inhibition of the mitochondrial adenine nucleotide transport system by oleyl CoA
Harris, R. A., Farmer, B. B., & Ozawa, T. (1972) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(72)90027-6 · Cited by 79 · see citing works
Propionate Inhibition of Succinate: CoA Ligase (GDP) and the Citric Acid Cycle in Mitochondria
Stumpf, D. A., Mcafee, J., Parks, J. K., & Eguren, L. A. (1980) · Pediatric Research · doi:10.1203/00006450-198010000-00008 · Cited by 78 · see citing works
Purification and Characterization of Long-Chain Acyl-CoA Hydrolase from Rat Liver Mitochondria
Berge, R. K., & Farstad, M. (1979) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1979.tb13051.x · Cited by 78 · see citing works
Inhibition by fatty acyl esters of adenine nucleotide translocation in rat‐liver mitochondria
Vaartjes, W. J., Kemp, A., Souverijn, J. H. M., & van den Bergh, S. G. (1972) · FEBS Letters · doi:10.1016/0014-5793(72)80302-8 · Cited by 77 · see citing works
In vitro alteration of the size of the liver mitochondrial adenine nucleotide pool: Correlation with respiratory functions
Asimakis, G. K., & Aprille, J. R. (1980) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(80)90181-2 · Cited by 76 · see citing works
Correlation between the cellular level of long-chain acyl-coa, peroxisomal β-oxidation, and palmitoyl-CoA hydrolase activity in rat liver. Are the two enzyme systems regulated by a substrate-induced mechanism?
Berge, R. K., & Aarsland, A. A. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90237-1 · Cited by 75 · see citing works
Long-chain fatty acids act as protonophoric uncouplers of oxidative phosphorylation in rat liver mitochondria
Schönfeld, P., Schild, L., & Kunz, W. (1989) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(89)80080-5 · Cited by 74 · see citing works
Self-citation
Characterization of the kinetics and mechanism of the mitochondrial ADP-atp carrier.
Barbour, R. L., & Chan, S. H. P. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69898-4 · Cited by 72 · see citing works
Chapter 17 The uncoupling protein thermogenin and mitochondrial thermogenesis
Nedergaard, J., & Cannon, B. (1992) · New comprehensive biochemistry · doi:10.1016/s0167-7306(08)60185-4 · Cited by 70 · see citing works
Proton conductance through phospholipid bilayers: Water wires or weak acids?
Gutknecht, J. (1987) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00770028 · Cited by 69 · see citing works
Regulation of the degree of coupling of oxidative phosphorylation in intact rat liver
Soboll, S., & Stucki, J. W. (1985) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(85)90255-5 · Cited by 69 · see citing works
Influence of fatty acids on energy metabolism
SCHOLZ, R., SCHWABE, U., & Soboll, S. (1984) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1984.tb08179.x · Cited by 69 · see citing works
Purification and Characteristics of a Butyryl Coenzyme A Synthetase from Bovine Heart Mitochondria
Webster, L. T., Gerowin, L. D., & Rakita, L. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)97609-x · Cited by 68 · see citing works
Influence of fatty acids on energy metabolism
Soboll, S., GRÜNDEL, S., SCHWABE, U., & SCHOLZ, R. (1984) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1984.tb08180.x · Cited by 68 · see citing works
Liver mitochondrial pyrophosphate concentration is increased by Ca2+ and regulates the intramitochondrial volume and adenine nucleotide content
Davidson, A. M., & Halestrap, A. P. (1987) · Biochemical Journal · doi:10.1042/bj2460715 · Cited by 68 · see citing works
Purification and Properties of Acetyl Coenzyme A Synthetase from Bovine Heart Mitochondria
Campagnari, F., & Webster, L. T. (1963) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81112-7 · Cited by 68 · see citing works
Oleic acid promotes changes in the subcellular distribution of protein kinase C in isolated hepatocytes.
Díaz-Guerra, M. J., Junco, M., & Boscá, L. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54321-0 · Cited by 67 · see citing works
Interaction of fatty acids with lipid bilayers
Rooney, E. K., East, J. M., Jones, O., McWhirter, J. M., Simmonds, A. C., & Lee, A. G. (1983) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(83)90467-4 · Cited by 67 · see citing works
The specific inhibition of the pyruvate dehydrogenase complex from pig kidney by propionyl-CoA and isovaleryl-CoA
Gregersen, N. (1981) · Biochemical Medicine · doi:10.1016/0006-2944(81)90026-0 · Cited by 66 · see citing works
The contribution of hepatic metabolism to diet-induced thermogenesis
Berry, M. N., Clark, D. G., Grivell, A. R., & Wallace, P. G. (1985) · Metabolism · doi:10.1016/0026-0495(85)90123-4 · Cited by 66 · see citing works
Regulation of Pyruvate Carboxylase in Rat Liver Mitochondria by Adenine Nucleotides and Short Chain Fatty Acids
Walter, P., & Stucki, J. W. (1970) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1970.tb00880.x · Cited by 65 · see citing works
Effect of Mg2+ depletion of mitochondria on their permeability to K+: The mechanism by which ionophore A23187 increases K+ permeability
Duszyński, J., & Wojtczak, L. (1977) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(77)90320-5 · Cited by 65 · see citing works
Self-citation
Hamster Brown‐Adipose‐Tissue Mitochondria
Heaton, G. M., & Nicholls, D. G. (1976) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1976.tb10717.x · Cited by 65 · see citing works
Induction of swelling of liver mitochondria by fatty acids of various chain length
Zborowski, J., & Wojtczak, L. (1963) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(63)90799-6 · Cited by 65 · see citing works
Self-citation
Reconstitution of the uncoupling protein of brown adipose tissue mitochondria. Demonstration of GDP-sensitive halide anion uniport.
Ježek, P., Orosz, D. E., & Garlid, K. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30657-9 · Cited by 63 · see citing works
Inhibited respiration and ATPase activity of rat liver mitochondria under conditions of matrix condensation
Nicholls, D. G., & Lindberg, O. R. (1972) · FEBS Letters · doi:10.1016/0014-5793(72)80454-x · Cited by 63 · see citing works
Intramitochondrial regulation of fatty acid β-oxidation occurs between flavoprotein and ubiquinone A role for changes in the matrix volume
Halestrap, A. P., & Dunlop, J. L. (1986) · Biochemical Journal · doi:10.1042/bj2390559 · Cited by 60 · see citing works
Effect of fatty acids and acyl‐CoA on the permeability of mitochondrial membranes to monovalent cations
Wojtczak, L. (1974) · FEBS Letters · doi:10.1016/0014-5793(74)80298-x · Cited by 59 · see citing works
Self-citation
31P NMR measurement of mitochondrial uncoupling in isolated rat hearts.
Kingsley-Hickman, P. B., Sako, E. Y., Uǧurbil, K., From, A. H. L., & Foker, J. E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40051-3 · Cited by 58 · see citing works
Induction of swelling of liver mitochondria by fatty acids of various chain length
Zborowski, J., & Wojtczak, L. (1963) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects · doi:10.1016/0926-6542(63)90088-x · Cited by 57 · see citing works
Self-citation
A Source of Nonshivering Thermogenesis in Fur Seal Skeletal Muscle
Grav, H. J., & Blix, A. S. (1979) · Science · doi:10.1126/science.219477 · Cited by 56 · see citing works
Uncoupling of oxidative phosphorylation. 2. Alternative mechanisms: intrinsic uncoupling or decoupling
Pietrobon, D., Luvisetto, S., & AZZONE, G. F. (1987) · Biochemistry · doi:10.1021/bi00397a022 · Cited by 56 · see citing works
The contribution of ATP turnover by the Na+/K+-ATPase to the rate of respiration of hepatocytes
Nobes, C. D., Lakin‐Thomas, P. L., & Brand, M. D. (1989) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(89)80236-1 · Cited by 55 · see citing works
Effects of arachidonic acid on respiratory activities in isolated brain mitochondria
Hillered, L., & Chan, P. H. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490190113 · Cited by 55 · see citing works
The regulation of mitochondrial-bound hexokinases in the liver
Weiler, U., Riesinger, I., Knoll, G., & Brdiczka, D. G. (1985) · Biochemical Medicine · doi:10.1016/0006-2944(85)90031-6 · Cited by 54 · see citing works
Alterations in liver mitochondrial function as a result of fasting and exhaustive exercise
Klug, G. A., Krause, J., Östlund, A.-K., Knoll, G., & Brdiczka, D. G. (1984) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(84)90097-5 · Cited by 54 · see citing works
Effect of Phospholipid Composition on the Surface Potential of Liposomes and the Activity of Enzymes Incorporated into Liposomes
Nałȩcz, M. J., Zborowski, J., Famulski, K. S., & Wojtczak, L. (1980) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1980.tb04988.x · Cited by 53 · see citing works
Self-citation
Protein kinase C subspecies in adult rat hippocampal synaptosomes Activation by diacylglycerol and arachidonic acid
Shearman, M. S., Shinomura, T., Oda, T., & Nishizuka, Y. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80163-w · Cited by 52 · see citing works
Induction of electroneutral exchanges of H + with K + in rat liver mitochondria
AZZONE, G. F., Bortolotto, F., Zanotti, A., & Pregnolato, L. (1978) · FEBS Letters · doi:10.1016/0014-5793(78)81078-3 · Cited by 51 · see citing works
Regulation of pyruvate dehydrogenase during infusion of fatty acids of varying chain lengths in the perfused rat heart
Latipää, P. M., PEUHKURINEN, K. J., Hiltunen, J. K., & Hassinen, I. E. (1985) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(85)80112-7 · Cited by 51 · see citing works
Effect of fatty acid oxidation on efficiency of energy production in rat heart
Hütter, J. F., Piper, H. M., & Spieckerman, P. G. (1985) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1985.249.4.h723 · Cited by 51 · see citing works
Distribution and Properties of Alkaline Pyrophosphatases of Rat Liver
Masachika, I. R. I. E., YABUTA, A., Kimura, K., Shindo, Y., & Tomita, K. (1970) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a129233 · Cited by 50 · see citing works
Anion Carriers of Mitochondrial Membranes.
Bolognani, L. (1990) · Bioelectrochemistry and Bioenergetics · doi:10.1016/0302-4598(80)85016-1 · Cited by 49 · see citing works
Proton/hydroxide conductance through phospholipid bilayer membranes: effects of phytanic acid
Gutknecht, J. (1987) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(87)90028-9 · Cited by 48 · see citing works
Inhibition of phosphoenolpyruvate transport via the tricarboxylate and adenine nucleotide carrier systems of rat liver mitochondria
Shug, A. L., & Shrago, E. S. (1973) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(73)90712-2 · Cited by 47 · see citing works
Studies on inactivation of pyruvate dehydrogenase by palmitoylcarnitine oxidation in isolated rat heart mitochondria.
Hansford, R. G. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40585-0 · Cited by 46 · see citing works
Inhibitors of the ATP/ADP antiporter suppress stimulation of mitochondrial respiration and H+ permeability by palmitate and anionic detergents
Brustovetsky, N., Dedukhova, V. I., Egorova, M. V., MOKHOVA, E. N., & Skulachev, V. P. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80480-7 · Cited by 46 · see citing works
Free fatty acids dissipate proton electrochemical gradients in pea stem microsomes and submitochondrial particles
Macrı̀, F., Vianello, A., Braidot, E., & Zancani, M. (1991) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(05)80244-0 · Cited by 46 · see citing works
Phosphorylation of adenosine monophosphate in the mitochondrial matrix
Krebs, H. A., & Wiggins, D. (1978) · Biochemical Journal · doi:10.1042/bj1740297 · Cited by 45 · see citing works
Uncoupling effect of fatty acids on heart muscle mitochondria and submitochondrial particles
Dedukhova, V. I., MOKHOVA, E. N., Skulachev, V. P., Starkov, A. A., Arrigoni‐Martelli, E., & Bobyleva, V. A. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)81382-i · Cited by 45 · see citing works
Effects of Octanoate and Oleate on Energy Metabolism in the Perfused Rat Liver
Debeer, L. J., Mannaerts, G. P., & Schepper, P. J. D. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03730.x · Cited by 43 · see citing works
Fatty acid-membrane interactions in isolated cardiac mitochondria and erythrocytes
Piper, H. M., Sezer, O., Schwartz, P. J., Hütter, J. F., & Spieckermann, P. G. (1983) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(83)90203-1 · Cited by 43 · see citing works
Fatty acid adsorption by liver- and adipose-tissue particles
Reshef, L., & Shapiro, B. (1965) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(65)90012-3 · Cited by 40 · see citing works
ATP-sensitive potassium channels in insulinoma cells are activated by nonesterified fatty acids
Mueller, M., Szewczyk, A. M., de Weille, J. R., & Lazdunski, M. (1992) · Biochemistry · doi:10.1021/bi00134a017 · Cited by 39 · see citing works
Molecular Biology of Mitochondrial Transport Systems
Forte, M. A., & Colombini, M. (1994) · Springer eBooks · doi:10.1007/978-3-642-78936-6 · Cited by 38 · see citing works
The effect of fatty acids on the surface potential of phospholipid vesicles measured by condensed phase radioluminescence
von Tscharner, V., & Radda, G. K. (1981) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(81)90087-0 · Cited by 38 · see citing works
Carboxyatractylate‐sensitive uncoupling in liver mitochondria from ground squirrels during hibernation and arousal
Brustovetsky, N., Amerkanov, Z. G., Yegorova, M. E., MOKHOVA, E. N., & Skulachev, V. P. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80481-w · Cited by 38 · see citing works
Free fatty acids decouple oxidative phosphorylation by dissipating intramembranal protons without inhibiting ATP synthesis driven by the proton electrochemical gradient
Rottenberg, H., & Steiner‐Mordoch, S. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)80708-6 · Cited by 36 · see citing works
Metabolism of Isolated Kidney Tubules
Guder, W., & WIELAND, O. H. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03368.x · Cited by 36 · see citing works
The effect of glucagon treatment and starvation of virgin and lactating rats on the rates of oxidation of octanoyl- l -carnitine and octanoate by isolated liver mitochondria
Zammit, V. A. (1980) · Biochemical Journal · doi:10.1042/bj1900293 · Cited by 35 · see citing works
New insights into mechanisms of anion uniport through the uncoupling protein of brown adipose tissue mitochondria
Garlid, K. (1990) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(90)90237-x · Cited by 34 · see citing works
K+/H+ antiport in mitochondria
Brierley, G. P., & Jung, D. W. (1988) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00768394 · Cited by 34 · see citing works
Studies on the Effects of Saturated and Unsaturated Short-Chain Monocarboxylic Acids on the Energy Metabolism of Rat Liver Mitochondria
Gregersen, N. (1979) · Pediatric Research · doi:10.1203/00006450-197911000-00005 · Cited by 34 · see citing works
The effect of non-esterified fatty acids on the proton-pumping cytochrome c oxidase reconstituted into liposomes
Labonia, N., Müller, M., & Azzi, A. (1988) · Biochemical Journal · doi:10.1042/bj2540139 · Cited by 34 · see citing works
The proteoliposomal steady state. Effect of size, capacitance and membrane permeability on cytochrome-oxidase-induced ion gradients
Wrigglesworth, J. M., Cooper, C. E., Sharpe, M. A., & Nicholls, P. J. (1990) · Biochemical Journal · doi:10.1042/bj2700109 · Cited by 33 · see citing works
Acyl-CoA synthetases in guinea-pig liver mitochondria
Groot, P. H. E. (1976) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(76)90169-7 · Cited by 33 · see citing works
Effect of fatty acids on pyruvate carboxylation in rat liver mitochondria
Wojtczak, A. B., Lenartowicz, E., Rodionova, M. A., & Duszyński, J. (1972) · FEBS Letters · doi:10.1016/0014-5793(72)80725-7 · Cited by 33 · see citing works
Mechanism of the stimulation of respiration by fatty acids in rat liver
PLOMP, P. J. A. M., van Roermund, C. W. T., Groen, A. K., Meijer, A. J., & Tager, J. M. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)80161-7 · Cited by 31 · see citing works
Anion permeation limits the uncoupling activity of fatty acids in mitochondria
Schönfeld, P. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80516-j · Cited by 30 · see citing works
Self-citation
Differential interaction of fatty acids and fatty acyl CoA esters with the purified/reconstituted brown adipose tissue mitochondrial uncoupling protein
Katiyar, S. S., & Shrago, E. S. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91679-7 · Cited by 30 · see citing works
Thermoregulatory, carboxyatractylate‐sensitive uncoupling in heart and skeletal muscle mitochondria of the ground squirrel correlates with the level of free fatty acids
Brustovetsky, N., Egorova, M. V., Gnutov, D. Y., Gogvadze, V. G., MOKHOVA, E. N., & Skulachev, V. P. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80645-w · Cited by 30 · see citing works
Alkaline pH, membrane potential, and magnesium cations are negative modulators of purine nucleotide inhibition of H+ and Cl− transport through the uncoupling protein of brown adipose tissue mitochondria
Ježek, P., Houštěk, J., & Drahota, Z. (1988) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00768922 · Cited by 29 · see citing works
A MITOCHONDRIAL FACTOR PRODUCING „LOOSE-COUPLING” OF RESPIRATION
Remmert, L. F., & Lehninger, A. L. (1959) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.45.1.1 · Cited by 29 · see citing works
Effect of detergents on ADP translocation in mitochondria
Duszyński, J., & Wojtczak, L. (1974) · FEBS Letters · doi:10.1016/0014-5793(74)80896-3 · Cited by 28 · see citing works
Self-citation
Acylation of Proteins by Myristic Acid in Isolated Mitochondria
Stucki, J. W., Lehmann, L. H., & Siegel, E. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83359-2 · Cited by 27 · see citing works
On the mechanism of the so-called uncoupling effect of medium- and short-chain fatty acids
Schönfeld, P., Wojtczak, A., Geelen, M. J. H., Kunz, W., & Wojtczak, L. (1988) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(88)90003-5 · Cited by 27 · see citing works
Self-citation
Adenine nucleotide efflux in mitochondria induced by inorganic pyrophosphate
D'Souza, M. P., & Wilson, D. F. (1982) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(82)90313-9 · Cited by 27 · see citing works
Acetyl-coenzyme A deacylase activity in liver is not an artifact. Subcellular distribution and substrate specificity of acetyl-coenzyme A deacylase activities in rat liver
Grigat, K.-P., Koppe, K., Seufert, C. D., & Söling, H. D. (1979) · Biochemical Journal · doi:10.1042/bj1770071 · Cited by 26 · see citing works
Mechanism of fatty acid effect on myocardial oxygen consumption. A phosphorus NMR study
Hassinen, I. E., Ito, K., Nioka, S., & Chance, B. (1990) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(90)90126-o · Cited by 26 · see citing works
Influence of dietary status on liver palmitoyl-coa hydrolase, peroxisomal enzymes, coash and long-chain acyl-coa in rats
Berge, R. K., Hosøy, L. H., & Farstad, M. (1984) · International Journal of Biochemistry · doi:10.1016/0020-711x(84)90139-3 · Cited by 26 · see citing works
Electrical potential dissipation induced by free fatty acids in pea stem mitochondria
Petrussa, E., Braidot, E., Nagy, G., Vianello, A., & Macrı̀, F. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80692-a · Cited by 25 · see citing works
In vitro effects of eight-carbon fatty acids on oxidations in rat liver mitochondria
Veitch, K., & HOOF, F. V. (1990) · Biochemical Pharmacology · doi:10.1016/0006-2952(90)90248-j · Cited by 25 · see citing works
Enhancement of transmembrane proton conductivity of protonophores by membrane-permeant cations
Ahmed, I., & Krishnamoorthy, G. (1990) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(90)90358-u · Cited by 24 · see citing works
The Inhibition of Isocitrate Oxidation by Palmitoyl‐ l ‐carnitine and Palmitoyl‐CoA in Rat Liver Mitochondria
Lenartowicz, E., WINTER, C., Kunz, W., & Wojtczak, A. (1976) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1976.tb10642.x · Cited by 22 · see citing works
Influence of the surface potential on the michaelis constant of membrane‐bound enzymes
Wojtczak, L., Famulski, K. S., Nałȩcz, M. J., & Zborowski, J. (1982) · FEBS Letters · doi:10.1016/0014-5793(82)80856-9 · Cited by 21 · see citing works
Self-citation
Acute postnatal regulation of pyruvate carboxylase activity by compartmentation of mitochondrial adenine nucleotides
Aprille, J. R., Yaswen, P., & Rulfs, J. (1981) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(81)90080-5 · Cited by 21 · see citing works
Relationship between pyruvate carboxylation and citrulline synthesis in rat liver mitochondria: The effect of ammonia and energy
Bryła, J., & Niedźwiecka, A. (1979) · International Journal of Biochemistry · doi:10.1016/0020-711x(79)90040-5 · Cited by 21 · see citing works
Effect of metal cations on the inhibition of adenine nucleotide translocation by acyl‐coa
Duszyński, J., & Wojtczak, L. (1975) · FEBS Letters · doi:10.1016/0014-5793(75)81044-1 · Cited by 20 · see citing works
Self-citation
Citrulline synthesis: Regulation by alterations in the total mitochondrial adenine nucleotide content
Goldstein, F. G., & Aprille, J. R. (1982) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(82)90433-7 · Cited by 19 · see citing works
Effect of oleate on the apparent Km of monoamine oxidase and the amount of membrane-bound hexokinase in isolated rat hepatocytes: Further evidence for the controlling role of the surface charge in hexokinase binding
Wojtczak, L., Adams, V., & Brdiczka, D. G. (1988) · Molecular and Cellular Biochemistry · doi:10.1007/bf00229394 · Cited by 18 · see citing works
Self-citation
Phosphorylation of mitochondrial membrane proteins: effect of the surface potential on monoamine oxidase
Famulski, K. S., Nałȩcz, M. J., & Wojtczak, L. (1983) · FEBS Letters · doi:10.1016/0014-5793(83)81129-6 · Cited by 18 · see citing works
Self-citation
Influence of cerebral ischemia and post-ischemic reperfusion on mitochondrial oxidative phosphorylation
Kurup, C. K. R., Kumaroo, K. K., & Dutka, A. J. (1990) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00762846 · Cited by 17 · see citing works
Influence of non‐esterified fatty acids on respiratory control of reconstituted cytochrome‐c oxidase
Thiel, C., & Kadenbach, B. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)81469-3 · Cited by 17 · see citing works
NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of the rat
Alexson, S. E. H., Svensson, L. T., & Nedergaard, J. (1989) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(89)90025-8 · Cited by 17 · see citing works
Ca2+-induced accumulation of pyrophosphate in mitochondria during acetate metabolism
Inoue, T., Yamada, T., Furuya, E., & Tagawa, K. (1989) · Biochemical Journal · doi:10.1042/bj2620965 · Cited by 16 · see citing works
STUDIES OF FATTY ACID OXIDATION: 5. THE EFFECT OF DECANOIC ACID ON OXIDATIVE PHOSPHORYLATION
Scholefield, P. G. (1956) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/y56-125 · Cited by 15 · see citing works
Role of fatty acid metabolites in the development of myocardial ischemic damage
Hütter, J. F., & Soboll, S. (1992) · International Journal of Biochemistry · doi:10.1016/0020-711x(92)90030-5 · Cited by 15 · see citing works
On the nature of the uncoupling effect of fatty acids
Luvisetto, S., Buso, M., Pietrobon, D., & Azzone, G. F. (1990) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00809068 · Cited by 15 · see citing works
Effect of the phosphorylation of microsomal proteins on the surface potential and enzyme activities
Famulski, K. S., Nałȩcz, M. J., & Wojtczak, L. (1979) · FEBS Letters · doi:10.1016/0014-5793(79)81341-1 · Cited by 14 · see citing works
Self-citation
The oxidation of long-chain unsaturated fatty acids by isolated rat liver mitochondria as a function of substrate concentration
Vaartjes, W. J., & van den Bergh, S. G. (1978) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(78)90143-3 · Cited by 13 · see citing works
Studies on the Influence of Fatty Acids on Pyruvate Dehydrogenase Interconversion in Rat‐Liver Mitochondria
Wałajtys-Rode, E. (1976) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1976.tb11109.x · Cited by 13 · see citing works
STUDIES OF FATTY ACID OXIDATION: 5. THE EFFECT OF DECANOIC ACID ON OXIDATIVE PHOSPHORYLATION
Scholefield, P. G. (1956) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o56-125 · Cited by 12 · see citing works
Studies of fatty acid oxidation. IX. The effects of uncoupling agents on the oxidation of fatty acids by transplantable tumors.
Ellis, D. B., & Scholefield, P. G. (1962) · PubMed · Cited by 10 · see citing works
Effect of monovalent cations on the inhibition by NAD+ of NADH oxidation in submitochondrial particles
Nał≐cz, M. J., & Wojtczak, L. (1978) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(78)91298-6 · Cited by 10 · see citing works
Self-citation
Mechanism of the stimulation of respiration by added substrate in hepatocytes
Brand, M. D., & Nobes, C. D. (1986) · Biochemical Society Transactions · doi:10.1042/bst0141200 · Cited by 10 · see citing works
Purification and characterization of mitochondrial thioesterase from rabbit myocardium and its inhibition by palmitoyl carnitine
GROSS, R. (1984) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(84)90161-2 · Cited by 9 · see citing works
The Effect of Membrane Potential on the Protonophoric Action of Oleic Acid
Martyn, A. S., Chris, E. C., & John, M. (1991) · Biochemical Society Transactions · doi:10.1042/bst019257s · Cited by 9 · see citing works
The inhibition of alpha-ketoglutarate oxidation by fatty acids in rat liver mitochondria.
Lenartowicz, E., & Olson, M. S. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34568-4 · Cited by 8 · see citing works
The effects of some short-chain fatty acids on pyruvate carboxylase activity in intact isolated rat liver mitochondria
STIRK, J.-H., Bartlett, K., & Sherratt, H. S. A. (1983) · Biochemical Society Transactions · doi:10.1042/bst0110286 · Cited by 8 · see citing works
ATP-Sensitive K+ Channel in Rat Liver Mitochondria: Functional Characteristics
Szewczyk, A. M., Pikuła, S., Wojtczak, L., & Nałęczl, M. J. (1994) · Springer eBooks · doi:10.1007/978-3-642-78936-6_16 · Cited by 6 · see citing works
Self-citation
The relationship between plasma free fatty acids and liver mitochondrial function in vivo
Bode, A. M., Byrd, S., & Klug, G. A. (1990) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(90)90042-v · Cited by 6 · see citing works
Oxidative phosphorylation in mitochondria of the wax moth and some other insects.
Wojtczak, A. B., Lągwińska, E., & Wojtczak, L. (1968) · PubMed · Cited by 6 · see citing works
Self-citation
Intramitochondrial fatty acid activation enhances control strength of adenine nucleotide translocase.
Schönfeld, P., & Bohnensack, R. (1991) · PubMed · Cited by 4 · see citing works
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Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
Zorov, D. B., Juhaszova, M., & Sollott, S. J. (2014) · Physiological Reviews · doi:10.1152/physrev.00026.2013 · Cited by 5,383 · see citing works
The mitochondrial permeability transition
Zoratti, M., & Szabó, I. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(95)00003-a · Cited by 2,395 · see citing works
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232 · see citing works
Are oxidative stress-activated signaling pathways mediators of insulin resistance and β-cell dysfunction?
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.1 · Cited by 1,482 · see citing works
Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus
Tangvarasittichai, S. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i3.456 · Cited by 1,238 · see citing works
Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies
Rani, V., Deep, G., Singh, R. K., Palle, K., & Yadav, U. C. S. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.02.002 · Cited by 1,151 · see citing works
Short- and medium-chain fatty acids in energy metabolism: the cellular perspective
Schönfeld, P., & Wojtczak, L. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r067629 · Cited by 1,088 · see citing works
Self-citation
Adipose tissue as an endocrine and paracrine organ
Mohamed‐Ali, V., Pinkney, J. H., & Coppack, S. W. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800770 · Cited by 999 · see citing works
Mechanisms of obesity-associated insulin resistance: many choices on the menuPreprint
Qatanani, M., & Lazar, M. A. (2007) · Genes & Development · doi:10.1101/gad.1550907 · Cited by 780 · see citing works
The Perfect Storm: Obesity, Adipocyte Dysfunction, and Metabolic Consequences
de Ferranti, S. D., & Mozaffarian, D. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.100156 · Cited by 732 · see citing works
Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity
Fromenty, B., & Pessayre, D. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)00012-6 · Cited by 665 · see citing works
UCP1: The only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency
Nedergaard, J., Golozoubova, V., Matthias, A., Asadi, A., Jacobsson, A., & Cannon, B. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00247-4 · Cited by 615 · see citing works
The ADP and ATP transport in mitochondria and its carrier
Klingenberg, M. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.04.011 · Cited by 613 · see citing works
Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane
Bernardi, P., Broekemeier, K. M., & Pfeiffer, D. R. (1994) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00762735 · Cited by 561 · see citing works
Mitochondria as a Pharmacological Target
Szewczyk, A. M., & Wojtczak, L. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.1.101 · Cited by 541 · see citing works
Self-citation
Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation
Tahara, E. B., Navarete, F. D. T., & Kowaltowski, A. J. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.02.008 · Cited by 479 · see citing works
The Role of Obesity in Type 2 Diabetes Mellitus—An Overview
Chandrasekaran, P., & Weiskirchen, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031882 · Cited by 540 · see citing works
Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases
Demine, S., Renard, P., & Arnould, T. (2019) · Cells · doi:10.3390/cells8080795 · Cited by 476 · see citing works
“Experiments performed on liposomes enriched in UCP-1 showed that FFAs are a required co-factor for UCP-1-catalyzed proton transport [29], suggesting that the uncoupling effect of FFAs could depend on this channel.”
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Mitochondrial Targets of Drug Toxicity
Wallace, K. B., & Starkov, A. A. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.353 · Cited by 464 · see citing works
Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy? - Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain
Schönfeld, P., & Reiser, G. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.128 · Cited by 457 · see citing works
Self-citation
Fatty acids as modulators of the cellular production of reactive oxygen species
Schönfeld, P., & Wojtczak, L. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.029 · Cited by 441 · see citing works
Self-citation
Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease
Tracey, T. J., Steyn, F. J., Wolvetang, E. J., & Ngo, S. T. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00010 · Cited by 433 · see citing works
Thermogenic Responses in Brown Fat Cells Are Fully UCP1-dependent
Matthias, A., Ohlson, K. B. E., Fredriksson, J. M., Jacobsson, A., Nedergaard, J., & Cannon, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000547200 · Cited by 342 · see citing works
Quercetin Decreases Oxidative Stress, NF-κB Activation, and iNOS Overexpression in Liver of Streptozotocin-Induced Diabetic Rats
Dias, A. S., Porawski, M., Alonso-Chamorro, M., Marroni, N. P., Collado, P. S., & González‐Gallego, J. (2005) · Journal of Nutrition · doi:10.1093/jn/135.10.2299 · Cited by 318 · see citing works
Metabolic and cellular plasticity in white adipose tissue I: effects of β<sub>3</sub>-adrenergic receptor activation
Granneman, J. G., Li, P., Zhu, Z., & Lu, Y. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00009.2005 · Cited by 298 · see citing works
Arachidonic Acid Causes Cell Death through the Mitochondrial Permeability Transition
Scorrano, L., Penzo, D., Petronilli, V., Pagano, F. C., & Bernardi, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010603200 · Cited by 294 · see citing works
Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury
Szeto, H. H., Liu, S., Soong, Y., Alam, N., Prusky, G. T., & Seshan, S. V. (2016) · Kidney International · doi:10.1016/j.kint.2016.06.013 · Cited by 293 · see citing works
Oxidative stress and metabolic pathologies: from an adipocentric point of view
Le Lay, S., Simard, G., Martinez, M. C., & Andriantsitohaina, R. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/908539 · Cited by 291 · see citing works
The adipocyte as an endocrine organ in the regulation of metabolic homeostasis
Harwood, H. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.12.010 · Cited by 273 · see citing works
H+ transport is an integral function of the mitochondrial ADP/ATP carrier
Bertholet, A. M., Chouchani, E. T., Kazak, L., Angelin, A., Fedorenko, A., Long, J. Z., Vidoni, S., Garrity, R., Cho, J., Terada, N., et al. (2019) · Nature · doi:10.1038/s41586-019-1400-3 · Cited by 256 · see citing works
Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?
Venn-Watson, S. K., Lumpkin, R., & Dennis, E. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-64960-y · Cited by 254 · see citing works
Mitochondrial and cellular mechanisms for managing lipid excess
Aon, M. A., Bhatt, N., & Cortassa, S. C. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00282 · Cited by 253 · see citing works
Nutritional and physiological role of medium-chain triglycerides and medium-chain fatty acids in piglets
Zentek, J., Buchheit-Renko, S., Ferrara, F., Vahjen, W., Kessel, A. G. V., & Pieper, R. (2011) · Animal Health Research Reviews · doi:10.1017/s1466252311000089 · Cited by 245 · see citing works
AMP-activated Protein Kinase Is Activated as a Consequence of Lipolysis in the Adipocyte
Gauthier, M., Miyoshi, H., Souza, S. C., Cacicedo, J. M., Saha, A. K., Greenberg, A. S., & Ruderman, N. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708177200 · Cited by 245 · see citing works
Muscle Mitochondrial ATP Synthesis and Glucose Transport/Phosphorylation in Type 2 Diabetes
Szendroedi, J., Schmid, A. I., Chmelik, M., Toth, C., Brehm, A., Krssak, M., Nowotny, P., Wolzt, M., Waldhausl, W., & Roden, M. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040154 · Cited by 243 · see citing works
Sodium Palmitate Induces Partial Mitochondrial Uncoupling and Reactive Oxygen Species in Rat Pancreatic Isletsin Vitro1
Carlsson, C., Borg, L., & Welsh, N. (1999) · Endocrinology · doi:10.1210/endo.140.8.6908 · Cited by 238 · see citing works
Lipotoxicity in type 2 diabetic cardiomyopathy
van de Weijer, T., Schrauwen‐Hinderling, V. B., & Schrauwen, P. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr212 · Cited by 235 · see citing works
Protective Effect of Estrogens Against Oxidative Damage to Heart and Skeletal Muscle In Vivo and In Vitro
Persky, A. M., Green, P. S., Stubley, L., Howell, C. O., Zaulyanov, L., Brazeau, G. A., & Simpkins, J. W. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22308.x · Cited by 233 · see citing works
Arachidonic acid interaction with the mitochondrial electron transport chain promotes reactive oxygen species generation
Cocco, T., Di, M., Papa, P., & Lorusso, M. P. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00034-9 · Cited by 228 · see citing works
Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy
Fourcade, S., Lopez-Erauskin, J., Galino, J., Duval, C., Naudi, A., Jove, M., Kemp, S., Villarroya, F., Ferrer, I., Pamplona, R., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn085 · Cited by 214 · see citing works
Human milk fat substitutes: Past achievements and current trends
Wei, W., Jin, Q., & Wang, X. (2019) · Progress in Lipid Research · doi:10.1016/j.plipres.2019.02.001 · Cited by 208 · see citing works
Fatty acid cycling mechanism and mitochondrial uncoupling proteins
Ježek, P., Engstová, H., Žáčková, M., Vercesi, A. E., Costa, A. D. T., Arruda, P., & Garlid, K. D. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00084-x · Cited by 196 · see citing works
Limitations of Cyclosporin A Inhibition of the Permeability Transition in CNS Mitochondria
Brustovetsky, N., & Dubinsky, J. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08229.2000 · Cited by 169 · see citing works
Fatty acids decrease mitochondrial generation of reactive oxygen species at the reverse electron transport but increase it at the forward transport
Schönfeld, P., & Wojtczak, L. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.04.005 · Cited by 163 · see citing works
Self-citation
No Evidence for a Basal, Retinoic, or Superoxide-induced Uncoupling Activity of the Uncoupling Protein 2 Present in Spleen or Lung Mitochondria
Couplan, E., del Mar Gonzalez-Barroso, M., Alves-Guerra, M. C., Ricquier, D., Goubern, M., & Bouillaud, F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202535200 · Cited by 161 · see citing works
Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes
Li, Y., Fromme, T., Schweizer, S., Schöttl, T., & Klingenspor, M. (2014) · EMBO Reports · doi:10.15252/embr.201438775 · Cited by 159 · see citing works
Interaction of free fatty acids with mitochondria: Coupling, uncoupling and permeability transition
Paola, M. D., & Lorusso, M. P. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.03.024 · Cited by 158 · see citing works
Adipose tissue: A motor for the inflammation associated with obesity
Vachharajani, V., & Granger, D. N. (2009) · IUBMB Life · doi:10.1002/iub.169 · Cited by 151 · see citing works
Dietary Flavonoid Quercetin and Associated Health Benefits—An Overview
Jan, A. T., Kamli, M. R., Murtaza, I., Singh, J. B., Ali, A., & Haq, Q. M. R. (2010) · Food Reviews International · doi:10.1080/87559129.2010.484285 · Cited by 146 · see citing works
Cold‐induced mitochondrial uncoupling and expression of chicken UCP and ANT mRNA in chicken skeletal muscle
Toyomizu, M., Ueda, M., Sato, S., Seki, Y., Sato, K., & Akiba, Y. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03395-1 · Cited by 143 · see citing works
Palmitate Induced Mitochondrial Deoxyribonucleic Acid Damage and Apoptosis in L6 Rat Skeletal Muscle Cells
Rachek, L. I., Musiyenko, S. I., LeDoux, S. P., & Wilson, G. L. (2007) · Endocrinology · doi:10.1210/en.2006-0998 · Cited by 137 · see citing works
Fluorescence lifetime imaging of endogenous biomarker of oxidative stress
Datta, R., Garcia, A. A., Cinco, R., & Gratton, E. (2015) · Scientific Reports · doi:10.1038/srep09848 · Cited by 133 · see citing works
6PPD-quinone exposure induces neuronal mitochondrial dysfunction to exacerbate Lewy neurites formation induced by α-synuclein preformed fibrils seeding
Fang, J., Wang, X., Cao, G., Wang, F., Ru, Y., Wang, B., Zhang, Y., Zhang, D., Yan, J., Xu, J. P., et al. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.133312 · Cited by 133 · see citing works
Increased uncoupling proteins and decreased efficiency in palmitate-perfused hyperthyroid rat heart
Boehm, E. A., Jones, B. E., Radda, G. K., Veech, R. L., & Clarke, K. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.3.h977 · Cited by 128 · see citing works
Effects of fatty acids on mitochondria: implications for cell death
Penzo, D., Tagliapietra, C., Colonna, R., Petronilli, V., & Bernardi, P. (2002) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(02)00272-4 · Cited by 127 · see citing works
Short‐term consumption of a high‐fat diet impairs whole‐body efficiency and cognitive function in sedentary men
Edwards, L. M., Murray, A. J., Holloway, C. J., Carter, E. E., Kemp, G. J., Codreanu, I., Brooker, H. J., Tyler, D. J., Robbins, P. A., & Clarke, K. (2010) · The FASEB Journal · doi:10.1096/fj.10-171983 · Cited by 127 · see citing works
Effects of Genetic Background on Thermoregulation and Fatty Acid-induced Uncoupling of Mitochondria in UCP1-deficient Mice
Hofmann, W. E., Liu, X., Bearden, C. M., Harper, M., & Kozak, L. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100466200 · Cited by 126 · see citing works
The reconstituted ADP/ATP carrier can mediate H+ transport by free fatty acids, which is further stimulated by mersalyl.
Brustovetsky, N., & Klingenberg, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46989-x · Cited by 121 · see citing works
Fatty acid‐induced uncoupling of oxidative phosphorylation is partly due to opening of the mitochondrial permeability transition pore
Wieckowski, M. R., & Wojtczak, L. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00118-5 · Cited by 121 · see citing works
Self-citation
Three-dimensional periodic cubic membrane structure in the mitochondria of amoebae Chaos carolinensis
Deng, Y., & Mieczkowski, M. (1998) · PROTOPLASMA · doi:10.1007/bf01280583 · Cited by 120 · see citing works
Thermodynamics and bioenergetics
Demi̇rel, Y., & Sandler, S. I. (2002) · Biophysical Chemistry · doi:10.1016/s0301-4622(02)00069-8 · Cited by 117 · see citing works
Acute Stimulation of White Adipocyte Respiration by PKA-Induced Lipolysis
Yehuda‐Shnaidman, E., Buehrer, B. M., Pi, J., Kumar, N., & Collins, S. (2010) · Diabetes · doi:10.2337/db10-0245 · Cited by 114 · see citing works
High-density lipoprotein ameliorates palmitic acid-induced lipotoxicity and oxidative dysfunction in H9c2 cardiomyoblast cells via ROS suppression
Wu, K.-M., Hsu, Y., Ying, M.-C., Tsai, F., Tsai, C., Chung, J., Yang, J., Tang, C., Cheng, L.-Y., Su, P.-H., et al. (2019) · Nutrition & Metabolism · doi:10.1186/s12986-019-0356-5 · Cited by 113 · see citing works
Homologues of the uncoupling protein from brown adipose tissue (UCP1): UCP2, UCP3, BMCP1 and UCP4
Bouillaud, F., Couplan, E., Pecqueur, C., & Ricquier, D. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00241-3 · Cited by 111 · see citing works
The Bioenergetics of Brown Fat Mitochondria from UCP1-ablated Mice
Matthias, A., Jacobsson, A., Cannon, B., & Nedergaard, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28150 · Cited by 112 · see citing works
The Mechanisms of Fatty Acid-Induced Proton Permeability of the Inner Mitochondrial Membrane
Wojtczak, L., & Wieckowski, M. R. (1999) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005444322823 · Cited by 109 · see citing works
Self-citation
Free fatty acid metabolism during myocardial ischemia and reperfusion
Hendrickson, S. C., Louis, J. D. S., Lowe, J. E., & Abdel‐aleem, S. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006886601825 · Cited by 108 · see citing works
Fatty acid‐promoted mitochondrial permeability transition by membrane depolarization and binding to the ADP/ATP carrier
Schönfeld, P., & Bohnensack, R. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01511-1 · Cited by 108 · see citing works
Self-citation
Involvement of the Dicarboxylate Carrier in the Protonophoric Action of Long-Chain Fatty Acids in Mitochondria
Wieckowski, M. R., & Wojtczak, L. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6298 · Cited by 108 · see citing works
Self-citation
Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes
Panigrahy, S. K., Bhatt, R., & Kumar, A. (2017) · Journal of Drug Targeting · doi:10.1080/1061186x.2016.1207650 · Cited by 103 · see citing works
Docosahexaenoic acid accumulates in cardiolipin and enhances HT-29 cell oxidant production
Watkins, S. M., Carter, L. C., & German, J. B. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32186-6 · Cited by 102 · see citing works
Mechanisms of non-alcoholic steatohepatitis
McClain, C. J., Mokshagundam, S. P., Barve, S. S., Song, Z., Hill, D. B., Chen, T., & Deaciuc, I. V. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.07.007 · Cited by 101 · see citing works
A Novel Kinetic Assay of Mitochondrial ATP-ADP Exchange Rate Mediated by the ANT
Chinopoulos, C., Vajda, S., Csanády, L., Mándi, M., Mathe, K., & Ádám‐Vizi, V. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.12.3915 · Cited by 100 · see citing works
Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes
Joseph, L. C., Barca, E., Subramanyam, P., Komrowski, M., Pajvani, U., Colecraft, H. M., Hirano, M., & Morrow, J. P. (2016) · PLOS ONE · doi:10.1371/journal.pone.0145750 · Cited by 99 · see citing works
Toxicity of Epoxy Fatty Acids and Related Compounds to Cells Expressing Human Soluble Epoxide Hydrolase
Greene, J. F., Newman, J. W. I., Williamson, K. C., & Hammock, B. D. (2000) · Chemical Research in Toxicology · doi:10.1021/tx990162c · Cited by 99 · see citing works
Type 2 diabetes – An autoinflammatory disease driven by metabolic stress
Gonzalez, L. L., Garrie, K., & Turner, M. D. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.034 · Cited by 98 · see citing works
Brain energy metabolism spurns fatty acids as fuel due to their inherent mitotoxicity and potential capacity to unleash neurodegeneration
Schönfeld, P., & Reiser, G. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.03.018 · Cited by 99 · see citing works
Self-citation
IL-6 induces lipolysis and mitochondrial dysfunction, but does not affect insulin-mediated glucose transport in 3T3-L1 adipocytes
Ji, C., Chen, X., Gao, C., Jiao, L., Wang, J., Xu, G., Fu, H., Guo, X., & Zhao, Y. (2011) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-011-9361-8 · Cited by 99 · see citing works
Mitochondrial Uncoupling: Role of Uncoupling Protein Anion Carriers and Relationship to Thermogenesis and Weight Control “The Benefits of Losing Control”
Diehl, A. M., & Hoek, J. B. (1999) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005452624640 · Cited by 95 · see citing works
Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat
Oeckl, J., Janovská, P., Adamcová, K., Bardová, K., Brunner, S. P., Dieckmann, S., Ecker, J., Fromme, T., Funda, J., Gantert, T., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101499 · Cited by 96 · see citing works
Free Fatty Acid Effects on Mitochondrial Permeability: An Overview
Sultan, A., & Sokolove, P. M. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2195 · Cited by 94 · see citing works
Evolutionary perspectives on the links between mitochondrial genotype and disease phenotype
Dowling, D. K. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.11.013 · Cited by 92 · see citing works
Mitochondrial H + Leak and Thermogenesis
Bertholet, A. M., & Kirichok, Y. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034405 · Cited by 93 · see citing works
Palmitic Acid Opens a Novel Cyclosporin A-Insensitive Pore in the Inner Mitochondrial Membrane
Sultan, A., & Sokolove, P. M. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2194 · Cited by 91 · see citing works
Antioxidants preserve redox balance and inhibit c-Jun-N-terminal kinase pathway while improving insulin signaling in fat-fed rats: evidence for the role of oxidative stress on IRS-1 serine phosphorylation and insulin resistance
Vinayagamoorthi, R., Bobby, Z., & Sridhar, M. G. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0061 · Cited by 91 · see citing works
Possible role for avPGC‐1α in the control of expression of fiber type, along with avUCP and avANT mRNAs in the skeletal muscles of cold‐exposed chickens
Ueda, M., Watanabe, K., Sato, K., Akiba, Y., & Toyomizu, M. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.11.039 · Cited by 92 · see citing works
Acute effect of fatty acids on metabolism and mitochondrial coupling in skeletal muscle
Hirabara, S. M., Silveira, L. R., Alberici, L. C., Leandro, C. V. G., Lambertucci, R. H., Polimeno, G. C., Cury‐Boaventura, M. F., Procópio, J., Vercesi, A. E., & Curi, R. (2005) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2005.11.007 · Cited by 89 · see citing works
Fatty acid-binding proteins in the heart
Schaap, F. G., Vusse, G. J., & Glatz, J. F. C. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006878621126 · Cited by 88 · see citing works
Mitochondrial energy dissipation by fatty acids
Bernardi, P., Penzo, D., & Wojtczak, L. (2002) · Vitamins and hormones · doi:10.1016/s0083-6729(02)65061-7 · Cited by 85 · see citing works
Self-citation
In vitro studies on the relationship between polyunsaturated fatty acids and cancer: tumour or tissue specific effects?
Diggle, C. P. (2002) · Progress in Lipid Research · doi:10.1016/s0163-7827(01)00025-x · Cited by 84 · see citing works
Evidence for Anion-translocating Plant Uncoupling Mitochondrial Protein in Potato Mitochondria
Ježek, P., Costa, A. D. T., & Vercesi, A. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32743 · Cited by 84 · see citing works
The Uncoupling Protein UCP1 Does Not Increase the Proton Conductance of the Inner Mitochondrial Membrane by Functioning as a Fatty Acid Anion Transporter
González‐Barroso, M. M., Fleury, C., Bouillaud, F., Nicholls, D. G., & Rial, E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15528 · Cited by 84 · see citing works
A 20/20 view of ANT function in mitochondrial biology and necrotic cell death
Bround, M. J., Bers, D. M., & Molkentin, J. D. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.05.012 · Cited by 83 · see citing works
Anti-tumor activities of lipids and lipid analogues and their development as potential anticancer drugs
Murray, M. T., Hraiki, A., Bebawy, M., Pazderka, C., & Rawling, T. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.01.008 · Cited by 83 · see citing works
Lipotoxicity, fatty acid uncoupling and mitochondrial carrier function
Rial, E., Rodríguez-Sánchez, L., Gallardo‐Vara, E., Zaragoza, P., Moyano, E., & González‐Barroso, M. M. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.04.001 · Cited by 80 · see citing works
Mitochondrial Fatty Acid β-Oxidation in the Human Eye and Brain: Implications for the Retinopathy of Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency
Tyni, T. A., Paetau, A. E., Strauss, A. W., Middleton, B., & Kivelä, T. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000141967.52759.83 · Cited by 80 · see citing works
Metabolic, structural and biochemical changes in diabetes and the development of heart failure
Ho, K. L., Karwi, Q. G., Connolly, D., Pherwani, S., Ketema, E. B., Ussher, J. R., & Lopaschuk, G. D. (2022) · Diabetologia · doi:10.1007/s00125-021-05637-7 · Cited by 79 · see citing works
Limited Mitochondrial Permeabilization Is an Early Manifestation of Palmitate-induced Lipotoxicity in Pancreatic β-Cells
Koshkin, V., Dai, F. F., Doucette, C. A., Chan, C. B., & Wheeler, M. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705652200 · Cited by 77 · see citing works
Cystic fibrosis-related diabetes: from CFTR dysfunction to oxidative stress.
Ntimbane, T., Comte, B., Mailhot, G., Berthiaume, Y., Poitout, V., Prentki, M., RABASA-LHORET, R. P. R., & Levy, E. H. (2009) · PubMed Central · Cited by 76 · see citing works
Inhibitory effect of palmitate on the mitochondrial NADH:ubiquinone oxidoreductase (complex I) as related to the active–de-active enzyme transition
LOSKOVICH, M. V., Grivennikova, V. G., Cecchini, G., & Vinogradov, A. D. (2005) · Biochemical Journal · doi:10.1042/bj20041703 · Cited by 76 · see citing works

Effect of long-chain fatty acids and acyl-CoA on mitochondrial permeability, transport, and energy-coupling processes
Wojtczak, L. (1976) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00765158 · Cited by 163 · see citing works
Self-citation
Long-chain fatty acids act as protonophoric uncouplers of oxidative phosphorylation in rat liver mitochondria
Schönfeld, P., Schild, L., & Kunz, W. (1989) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(89)80080-5 · Cited by 74 · see citing works
Self-citation
Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation
Skulachev, V. P. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80658-p · Cited by 467 · see citing works
A threshold membrane potential accounts for controversial effects of fatty acids on mitochondrial oxidative phosphorylation
Köhnke, D., Ludwig, B., & Kadenbach, B. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81616-8 · Cited by 32 · see citing works
Interaction of free fatty acids with mitochondria during uncoupling of oxidative phosphorylation
Samartsev, V. N., Rybakova, S. R., & Dubinin, M. V. (2013) · BIOPHYSICS · doi:10.1134/s0006350913030147 · Cited by 7 · see citing works

Authors: Wojtczak, L., & Schönfeld, P.
Affiliations: Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
Corresponding author: Wojtczak, Lech
Venue: Biochimica et Biophysica Acta (BBA) - Bioenergetics
Publisher: Elsevier BV
Published: 1993-11
Volume: 1183
Issue: 1
Pages: 41-57
ISSN: 0005-2728 (ISSN-L)
DOI: 10.1016/0005-2728(93)90004-y
OpenAlex: W1967880167
Cited by: 363
References: 200
Citations by year: 2026: 4 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 13 · 2021: 9 · 2020: 8 · 2019: 10 · 2018: 4 · 2017: 13 · 2016: 20 · 2015: 22 · 2014: 17 · 2013: 12 · 2012: 8
FWCI: 0.81
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Bioenergetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Keywords: long-chain fatty acids, mitochondrial uncoupling, adenine nucleotide translocase, electron transport inhibition, short- and medium-chain fatty acids, acyl-CoA, mitochondrial membrane permeability, alkali metal cations, thermogenesis, brown adipose tissue, thermogenin, membrane surface charge, fatty acid accumulation
MeSH terms: Uncoupling Protein 1, Animals, Adipose Tissue, Brown, Carrier Proteins, Fatty Acids, Ion Channels, Membrane Proteins, Mitochondria, Muscles, Oxidation-Reduction, Uncoupling Agents, Mitochondrial Proteins

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Effect of fatty acids on energy coupling processes in mitochondria

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