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Metabolic and cellular plasticity in white adipose tissue I: effects of β3-adrenergic receptor activation
Abstract
Selective agonists of β 3-adrenergic receptors (Adrb3) exhibit potent anti-diabetes properties in rodent models when given chronically, yet the mechanisms involved are poorly understood. A salient feature of chronic Adrb3 activation is pronounced remodeling of white adipose tissue (WAT), which includes mitochondrial biogenesis and elevation of metabolic rate. To gain insights into potential mechanisms underlying WAT remodeling, the time course of remodeling induced by the Adrb3 agonist CL-316,243 (CL) was analyzed using histological, physiological, and global gene profiling approaches. The results indicate that continuous CL treatment induced a transient proinflammatory response that was followed by cellular proliferation among stromal cells and multilocular adipoctyes. CL treatment strongly fragmented the central lipid storage droplet of mature adipocytes and induced mitochondrial biogenesis within these cells. Mitochondrial biogenesis was correlated with the upregulation of genes involved in fatty acid oxidation and mitochondrial electron transport activity. The elevated catabolic activity of WAT was temporally correlated with upregulation of peroxisome proliferator-activated receptor-α and its target genes, suggesting involvement of this transcription factor in coordinating the gene program that elevates WAT catabolic activity.
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“Recently, Kosteli and colleagues demonstrated that acute weight loss is unexpectedly associated with a rapid -albeit transient -lipolytic-driven recruitment of macrophages into AT (39), thereby confirming similar reports by Granneman and colleagues (44).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [44]
In the citing paper
“Mitochondrial levels in white adipocytes are also increased in response to adrenergic stimulation, -3 agonists, and CB1 blockade in mice (195,199,200), again in parallel with enhanced insulin sensitivity.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [199]
Citations
Cites
The Database of Interacting Proteins: 2004 update
Salwinski, L. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh086 · Cited by 2,271
The changing global patterns of female breast cancer incidence and mortality
Bray, F., McCarron, P., & Parkin, D. M. (2004) · Breast Cancer Research · doi:10.1186/bcr932 · Cited by 1,006
Guerra, C., Koza, R. A., Yamashita, H., Walsh, K., & Kozak, L. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3155 · Cited by 635
Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes
Himms-Hagen, J., Melnyk, A., Zingaretti, M. C., Ceresi, E., Barbatelli, G., & Cinti, S. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.3.c670 · Cited by 593
Kharroubi, I., Ladrière, L., Cardozo, A. K., Doğusan, Z., Cnop, M., & Eizirik, D. L. (2004) · Endocrinology · doi:10.1210/en.2004-0478 · Cited by 582
Gulick, T., Cresci, S., Caira, T., Moore, D. D., & Kelly, D. P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11012 · Cited by 567
Profiling Gene Expression Using Onto-Express
Khatri, P., Drăghici, S., Ostermeier, G. C., & Krawetz, S. A. (2002) · Genomics · doi:10.1006/geno.2002.6698 · Cited by 459
Fata, J. E., Werb, Z., & Bissell, M. J. (2003) · Breast Cancer Research · doi:10.1186/bcr634 · Cited by 406
Stephens, J. M., & Pekala, P. H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54714-1 · Cited by 370
Effect of fatty acids on energy coupling processes in mitochondria
Wojtczak, L., & Schönfeld, P. (1993) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(93)90004-y · Cited by 363
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Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373
Adipose tissue remodeling and obesity
Sun, K., Kusminski, C. M., & Scherer, P. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45887 · Cited by 1,941
Tracking adipogenesis during white adipose tissue development, expansion and regeneration
Wang, Q. A., Tao, C., Gupta, R. K., & Scherer, P. E. (2013) · Nature Medicine · doi:10.1038/nm.3324 · Cited by 1,262
Barbatelli, G., Murano, I., Madsen, L., Hao, Q., Jimenez, M., Kristiansen, K., Giacobino, J., Matteis, R. D., & Cinti, S. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00600.2009 · Cited by 788
Cinti, S. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.010 · Cited by 720
Lee, Y., Petkova, A. P., Mottillo, E. P., & Granneman, J. G. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.009 · Cited by 710
Self-citationAdipocyte inflammation is essential for healthy adipose tissue expansion and remodeling
Wernstedt Asterholm, I., Tao, C., Morley, T. S., Wang, Q. A., Delgado-Lopez, F., Wang, Z. V., & Scherer, P. E. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.005 · Cited by 668
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Greenberg, A. S., Coleman, R., Kraemer, F. B., McManaman, J. L., Obin, M. S., Puri, V., Yan, Q.-W., Miyoshi, H., & Mashek, D. G. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46069 · Cited by 620
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Patti, M.-E., & Corvera, S. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0027 · Cited by 551
McArdle, M. A., Finucane, O. M., Connaughton, R. M., McMorrow, A. M., & Roche, H. M. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00052 · Cited by 552
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Vitali, A., Murano, I., Zingaretti, M. C., Frontini, A., Ricquier, D., & Cinti, S. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m018846 · Cited by 487
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Frontini, A., & Cinti, S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.004 · Cited by 484
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Zhang, Z., Zhang, H., Li, B., Meng, X.-J., Wang, J., Zhang, Y., Yao, S., Ma, Q., Jin, L., Yang, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms6493 · Cited by 445
Nishino, N., Tamori, Y., Tateya, S., Kawaguchi, T., Shibakusa, T., Mizunoya, W., Inoue, K., Kitazawa, R., Kitazawa, S., Matsuki, Y., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34090 · Cited by 388
Transdifferentiation properties of adipocytes in the adipose organ
Cinti, S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00183.2009 · Cited by 379
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Qian, S., Tang, Y., Li, X., Liu, Y., Zhang, Y.-Y., Huang, H.-Y., Xue, R.-D., Yu, H.-Y., Guo, L., Gao, H.-D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215236110 · Cited by 320
Hondares, E., Rosell, M., Díaz-Delfín, J., Olmos, Y., Monsalve, M., Iglesias, R., Villarroya, F., & Giralt, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.252775 · Cited by 302
Cellular origins of cold‐induced brown adipocytes in adult mice
Lee, Y., Petkova, A. P., Konkar, A. A., & Granneman, J. G. (2014) · The FASEB Journal · doi:10.1096/fj.14-263038 · Cited by 291
Self-citationMottillo, E. P., Balasubramanian, P., Lee, Y., Weng, C., Kershaw, E. E., & Granneman, J. G. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m050005 · Cited by 282
Self-citationPharmacological and nutritional agents promoting browning of white adipose tissue
Bonet, M. L., Oliver, P., & Palou, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.12.002 · Cited by 286
Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration
Lee, Y., Petkova, A. P., & Granneman, J. G. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.003 · Cited by 293
Self-citationGiordano, A., Smorlesi, A., Frontini, A., Barbatelli, G., & Cinti, S. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-0945 · Cited by 298
Lee, J. H., Park, A., Oh, K., Lee, S. C., Kim, W. K., & Bae, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194924 · Cited by 280
Crossno, J. T., Majka, S. M., Grazia, T. J., Gill, R. G., & Klemm, D. J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28510 · Cited by 270
Lipid droplet-organelle interactions; sharing the fats
Murphy, S., Martin, S., & Parton, R. G. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.07.004 · Cited by 265
Remodeling of White Adipose Tissue after Retinoic Acid Administration in Mice
Mercader, J., Ribot, J., Murano, I., Felipe, F., Cinti, S., Bonet, M. L., & Palou, A. (2006) · Endocrinology · doi:10.1210/en.2006-0760 · Cited by 244
Convertible visceral fat as a therapeutic target to curb obesity
Giordano, A., Frontini, A., & Cinti, S. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.31 · Cited by 241
Bertholet, A. M., Kazak, L., Chouchani, E. T., Bogaczyńska, M. G., Paranjpe, I., Wainwright, G. L., Bétourné, A., Kajimura, S., Spiegelman, B. M., & Kirichok, Y. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.002 · Cited by 225
Interactions of Perilipin-5 (Plin5) with Adipose Triglyceride Lipase
Granneman, J. G., Moore, H. P., Mottillo, E. P., Zhu, Z., & Zhou, L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.180711 · Cited by 222
Self-citationInduction of Adipose Tissue Browning as a Strategy to Combat Obesity
Kuryłowicz, A., & Puzianowska-Kuźnicka, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176241 · Cited by 219
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Lee, Y., Mottillo, E. P., & Granneman, J. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.011 · Cited by 236
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Sánchez-Gurmaches, J., Hung, C., & Guertin, D. A. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.01.004 · Cited by 225
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Frontini, A., Vitali, A., Perugini, J., Murano, I., Romiti, C., Ricquier, D., Guerrieri, M., & Cinti, S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.02.005 · Cited by 218
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Sacks, H. S., Fain, J. N., Bahouth, S. W., Ojha, S., Frontini, A., Budge, H., Cinti, S., & Symonds, M. E. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1265 · Cited by 218
Murano, I., Barbatelli, G., Giordano, A., & Cinti, S. (2009) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.01001.x · Cited by 208
Adipose tissue and adipocyte dysregulation
Lafontan, M. (2013) · Diabetes & Metabolism · doi:10.1016/j.diabet.2013.08.002 · Cited by 218
Madsen, L., Pedersen, L. M., Lillefosse, H. H., Fjære, E., Brønstad, I., Hao, Q., Petersen, R. K., Hallenborg, P., Ma, T., Matteis, R. D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011391 · Cited by 204
Mottillo, E. P., Bloch, A. E., Leff, T., & Granneman, J. G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.374041 · Cited by 205
Self-citationBAT: a new target for human obesity?
Frühbeck, G., Becerril, S., Sáinź, N., Garrastachu, P., & García‐Velloso, M. J. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.05.003 · Cited by 198
Schoiswohl, G., Stefanović-Račić, M., Menke, M., Wills, R. C., Surlow, B. A., Basantani, M. K., Sitnick, M. T., Cai, L., Yazbeck, C. F., Stolz, D. B., et al. (2015) · Endocrinology · doi:10.1210/en.2015-1322 · Cited by 195
UCP1 governs liver extracellular succinate and inflammatory pathogenesis
Mills, E. L., Harmon, C., Jedrychowski, M. P., Xiao, H., Garrity, R., Tran, N., Bradshaw, G. A., Fu, A., Szpyt, J., Reddy, A. J., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00389-5 · Cited by 189
The adipose organ: white‐brown adipocyte plasticity and metabolic inflammation
Smorlesi, A., Frontini, A., Giordano, A., & Cinti, S. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01039.x · Cited by 189
White-to-brown metabolic conversion of human adipocytes by JAK inhibition
Moisan, A., Lee, Y., Zhang, J. D., Hudak, C. S. S., Meyer, C. A., Prummer, M., Zoffmann, S., Truong, H., Ebeling, M., Kiialainen, A., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3075 · Cited by 182
Adipose tissue lipolysis and remodeling during the transition period of dairy cows
Contreras, G. A., Strieder‐Barboza, C., & Raphael, W. (2017) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-017-0174-4 · Cited by 187
Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus
Guilherme, A., Henriques, F. D. S., Bedard, A. H., & Czech, M. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0165-y · Cited by 179
The Importance of Breast Adipose Tissue in Breast Cancer
Kothari, C., Diorio, C., & Durocher, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165760 · Cited by 181
The Implication of Brown Adipose Tissue for Humans
Ravussin, É., & Galgani, J. E. (2011) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-072610-145209 · Cited by 173
Myocardin-Related Transcription Factor A Regulates Conversion of Progenitors to Beige Adipocytes
McDonald, M. E., Li, C., Bian, H.-J., Smith, B. D., Layne, M. D., & Farmer, S. R. (2015) · Cell · doi:10.1016/j.cell.2014.12.005 · Cited by 167
Adipose Organ Development and Remodeling
Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 197
Free radicals and male reproduction.
Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154
Between brown and white: Novel aspects of adipocyte differentiation
Cinti, S. (2011) · Annals of Medicine · doi:10.3109/07853890.2010.535557 · Cited by 169
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Asterholm, I. W., & Scherer, P. E. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090647 · Cited by 157
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Donato, M., Xu, Z., Tomoiaga, A. S., Granneman, J. G., MacKenzie, R. G., Bao, R., Than, N. G., Westfall, P. H., Romero, R. J., & Drăghici, S. (2013) · Genome Research · doi:10.1101/gr.153551.112 · Cited by 152
Self-citationCurcumin promotes browning of white adipose tissue in a norepinephrine-dependent way
Wang, S., Wang, X., Ye, Z., Xu, C., Zhang, M., Ruan, B., Wei, M., Jiang, Y., Zhang, Y., Wang, L., et al. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.09.018 · Cited by 150
Flachs, P., Rossmeisl, M., Kuda, O., & Kopecký, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.02.003 · Cited by 154
Li, P., Zhu, Z., Lu, Y., & Granneman, J. G. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00010.2005 · Cited by 143
Self-citationPerrone, C. E., Mattocks, D. A. L., Jarvis-Morar, M., Plummer, J. D., & Orentreich, N. (2010) · Metabolism · doi:10.1016/j.metabol.2009.10.023 · Cited by 136
β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity
Valentine, J. M., Ahmadian, M., Keinan, O., Abu-Odeh, M., Zhao, P., Zhou, X., Keller, M. P., Gao, H., Yu, R. T., Liddle, C., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci153357 · Cited by 152
LSD1 promotes oxidative metabolism of white adipose tissue
Duteil, D., Metzger, E., Willmann, D., Karagianni, P., Friedrichs, N., Greschik, H., Günther, T., Buettner, R., Talianidis, I., METZGER, D., et al. (2014) · Nature Communications · doi:10.1038/ncomms5093 · Cited by 129
Cinti, S. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.05.007 · Cited by 134
Pavlovic, Z., & Bakovic, M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14022529 · Cited by 113
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Singh, R., Barrios, A., Dirakvand, G., & Pervin, S. (2021) · Cells · doi:10.3390/cells10113030 · Cited by 114
Shen, W., Liu, K., Tian, C., Yang, L., Li, X., Ren, J., Packer, L., Cotman, C. W., & Liu, J. (2007) · Diabetologia · doi:10.1007/s00125-007-0852-4 · Cited by 101
Langin, D. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.09.008 · Cited by 107
Methionine restriction on lipid metabolism and its possible mechanisms
Zhou, X., He, L., Wan, D., HuanSheng, Y., Yao, K., Wu, G., Wu, X., & Yin, Y. (2016) · Amino Acids · doi:10.1007/s00726-016-2247-7 · Cited by 102
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Jash, S., Banerjee, S., Lee, M., Farmer, S. R., & Puri, V. (2019) · iScience · doi:10.1016/j.isci.2019.09.011 · Cited by 96
Plaisance, E. P., Henagan, T. M., Echlin, H., Boudreau, A., Hill, K. L., Lenard, N. R., Hasek, B. E., Orentreich∥, N., & Gettys, T. W. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00838.2009 · Cited by 95
Mottillo, E. P., Shen, X., & Granneman, J. G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.04.012 · Cited by 92
Self-citationWeiner, J., Kranz, M., Klöting, N., Kunath, A., Steinhoff, K. G., Rijntjes, E., Köhrle, J., Zeisig, V., Hankir, M. K., Gebhardt, C., et al. (2016) · Scientific Reports · doi:10.1038/srep38124 · Cited by 98
Koh, Y. J., Kang, S., Lee, H. J., Choi, T., Lee, H. S., Cho, C., & Koh, G. Y. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32504 · Cited by 93
Cattaneo, P., Mukherjee, D., Spinozzi, S., Zhang, L., Larcher, V., Stallcup, W. B., Kataoka, H., Chen, J., Dimmeler, S., Evans, S. Μ., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.046 · Cited by 89
β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity
Valentine, J. M., Ahmadian, M., Keinan, O., Abu-Odeh, M., Zhao, P., Zhou, X., Keller, M. P., Gao, H., Yu, R. T., Liddle, C., et al. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 89
Reversible physiological transdifferentiation in the adipose organ
Cinti, S. (2009) · Proceedings of The Nutrition Society · doi:10.1017/s0029665109990140 · Cited by 89
Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue
Wankhade, U. D., Shen, M., Yadav, H., & Thakali, K. M. (2016) · BioMed Research International · doi:10.1155/2016/2365609 · Cited by 91
Mitochondria and endocrine function of adipose tissue
Medina‐Gómez, G. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.06.002 · Cited by 92
Single cell approaches to address adipose tissue stromal cell heterogeneity
Rondini, E. A., & Granneman, J. G. (2020) · Biochemical Journal · doi:10.1042/bcj20190467 · Cited by 90
Self-citationIn Vivo Physiological Transdifferentiation of Adult Adipose Cells
Matteis, R. D., Zingaretti, M. C., Murano, I., Vitali, A., Frontini, A., Giannulis, I., Barbatelli, G., Marcucci, F., Bordicchia, M., Sarzani, R., et al. (2009) · Stem Cells · doi:10.1002/stem.197 · Cited by 83
Role of hormone-sensitive lipase in β-adrenergic remodeling of white adipose tissue
Mottillo, E. P., Shen, X., & Granneman, J. G. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00051.2007 · Cited by 86
Self-citationNeural control of white, beige and brown adipocytes
Bartness, T. J., & Ryu, V. (2015) · International Journal of Obesity Supplements · doi:10.1038/ijosup.2015.9 · Cited by 84
Adipocyte lipolysis-stimulated interleukin-6 production requires sphingosine kinase 1 activity
Zhang, W., Mottillo, E. P., Zhao, J., Gartung, A., VanHecke, G. C., Lee, J.-F., Maddipati, K. R., Xu, H., Ahn, Y.-H., Proia, R. L., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.601096 · Cited by 80
Self-citationConcise Review: Adipocyte Origins: Weighing the Possibilities
Majka, S. M., Barak, Y., & Klemm, D. J. (2011) · Stem Cells · doi:10.1002/stem.653 · Cited by 81
Contreras, G. A., Lee, Y., Mottillo, E. P., & Granneman, J. G. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00033.2014 · Cited by 75
Self-citationAdrenoceptors in white, brown, and brite adipocytes
Evans, B. A., Merlin, J., Bengtsson, T., & Hutchinson, D. S. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14631 · Cited by 81
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Kochetkova, M., & Samuel, M. S. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.11.008 · Cited by 76
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Pope, M., Budge, H., & Symonds, M. E. (2013) · Acta Physiologica · doi:10.1111/apha.12053 · Cited by 82
Butyrate and obesity: Current research status and future prospect
Peng, K., Dong, W., Luo, T., Tang, H., Zhu, W., Huang, Y., & Yang, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1098881 · Cited by 81
Contreras, G. A., Kabara, E. A., Brester, J. L., Neuder, L. M., & Kiupel, M. (2015) · Journal of Dairy Science · doi:10.3168/jds.2015-9370 · Cited by 76
Chang, J. S., Fernand, V. E., Zhang, Y., Shin, J., Jun, H., Joshi, Y., & Gettys, T. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.320200 · Cited by 75
Deficiency of TNFα Converting Enzyme (TACE/ADAM17) Causes a Lean, Hypermetabolic Phenotype in Mice
Gelling, R. W., Yan, W., Al‐Noori, S., Pardini, A. W., Morton, G. J., Ogimoto, K., Schwartz, M. W., & Dempsey, P. J. (2008) · Endocrinology · doi:10.1210/en.2008-0775 · Cited by 75
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Ariotti, N., Murphy, S., Hamilton, N., Wu, L., Green, K., Schieber, N. L., Li, P., Martin, S., & Parton, R. G. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0847 · Cited by 74
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Metadata
- Authors
- Granneman, J. G., Li, P., Zhu, Z., & Lu, Y.
- Affiliations
- Wayne State University (US)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2005-10
- Volume
- 289
- Issue
- 4
- Pages
- E608-E616
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W1981281539
- Cited by
- 298
- References
- 46
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 9 · 2023: 11 · 2022: 6 · 2021: 14 · 2020: 11 · 2019: 17 · 2018: 12 · 2017: 15 · 2016: 23 · 2015: 22 · 2014: 28 · 2013: 26 · 2012: 21
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r21dk066505-02)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 062292, DK 066505)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- beta3-adrenergic receptor, white adipose tissue remodeling, CL316,243, mitochondrial biogenesis, adipocyte lipolysis, fatty acid oxidation, PPARα, adipocyte inflammation, adipocyte proliferation, metabolic rate, anti-diabetic effects, adipocyte gene expression
- MeSH terms
- Adaptation, Physiological, Adipose Tissue, Animals, Dioxoles, Energy Metabolism, Male, Mice, Inbred C57BL, Mitochondria, Gene Expression Profiling, Receptors, Adrenergic, beta-3, Cell Size, Cell Proliferation, Mice, Adrenergic beta-3 Receptor Agonists
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