The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function
Abstract
Male obesity is associated with reduced sperm motility and morphology and increased sperm DNA damage and oxidative stress; however, the reversibility of these phenotypes has never been studied. Therefore, the aim of this study was to assess the reversibility of obesity and its associated sperm physiology and function in mice in response to weight loss through diet and exercise. C57BL6 male mice ( n = 40) were fed either a control diet (CD; 6% fat) or a high-fat diet (HFD; 21% fat) for 10 wk before allocation to either diet and/or swimming exercise interventions for 8 wk. Diet alone reduced adiposity (1.6-fold) and serum cholesterol levels (1.7-fold, P < 0.05), while exercise alone did not alter these, but exercise plus diet also improved glucose tolerance (1.3-fold, P < 0.05). Diet and/or exercise improved sperm motility (1.2-fold) and morphology (1.1-fold, P < 0.05), and reduced sperm DNA damage (1.5-fold), reactive oxygen species (1.1-fold), and mitochondrial membrane potential (1.2-fold, P < 0.05) and increased sperm binding (1.4-fold) ( P < 0.05). Sperm parameters were highly correlated with measures of glycemia, insulin action, and serum cholesterol (all P < 0.05) regardless of adiposity or intervention, suggesting a link between systemic metabolic status and sperm function. This is the first study to show that the abnormal sperm physiology resulting from obesity can be reversed through diet and exercise, even in the presence of ongoing obesity, suggesting that diet and lifestyle interventions could be a combined approach to target subfertility in overweight and obese men.
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Cites
Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
Ng, S.-F., Lin, R. C. Y., Laybutt, D. R., Barres, R., Owens, J. A., & Morris, M. J. (2010) · Nature · doi:10.1038/nature09491 · Cited by 1,327
Self-citationWeight loss, exercise, or both and physical function in obese older adults
Villareal, D. T., Chode, S., Parimi, N., Sinacore, D. R., Hilton, T., Armamento-Villareal, R., Napoli, N., Qualls, C., & Shah, K. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1008234 · Cited by 1,096
Nguyen, D. M., & El-Serag, H. B. (2010) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2009.12.014 · Cited by 531
Rector, R. S., Thyfault, J. P., Morris, R. T., Laye, M. J., Borengasser, S. J., Booth, F. W., & Ibdah, J. A. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00428.2007 · Cited by 321
Treatment of male infertility secondary to morbid obesity
Roth, M. Y., Amory, J. K., & Page, S. T. (2008) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0844 · Cited by 115
Effect of Massive Weight Loss on Hypothalamic Pituitary-Gonadal Function in Obese Men*
STRAIN, G. W., ZUMOFF, B., MILLER, L. K., ROSNER, W., LEVIT, C., KALIN, M., HERSHCOPF, R. J., & ROSENFELD, R. S. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-5-1019 · Cited by 103
Cited by
Origins of lifetime health around the time of conception: causes and consequences
Fleming, T. P., Watkins, A. J., Velazquez, M. A., Mathers, J. C., Prentice, A. M., Stephenson, J., Barker, M., Saffery, R., Yajnik, C. S., Eckert, J. J., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30312-x · Cited by 1,147
Lifestyle factors and reproductive health: taking control of your fertility
Sharma, R., Biedenharn, K. R., Fedor, J. M., & Agarwal, A. (2013) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-11-66 · Cited by 845
Fullston, T., Teague, E. M. C. O., Palmer, N. O., DeBlasio, M. J., Mitchell, M., Corbett, M., Print, C. G., Owens, J. A., & Lane, M. (2013) · The FASEB Journal · doi:10.1096/fj.12-224048 · Cited by 600
Self-citationSalas-Huetos, A., Bulló, M., & Salas-Salvadó, J. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx006 · Cited by 491
Causes and consequences of oxidative stress in spermatozoa
Aitken, R. J., Gibb, Z., Baker, M. A., Drevet, J., & Gharagozloo, P. (2015) · Reproduction, Fertility and Development · doi:10.1071/rd15325 · Cited by 428
Metadata
- Authors
- Palmer, N. O., Bakos, H. W., Owens, J. A., Setchell, B. P., & Lane, M.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2012-04-01
- Volume
- 302
- Issue
- 7
- Pages
- E768-E780
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2168777985
- Cited by
- 217
- References
- 6
- FWCI
- 16.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Palmer, N. O., Bakos, H. W., Owens, J. A., Setchell, B. P., & Lane, M. (2012). Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00401.2011
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