Expression of uncoupling protein 3 is upregulated in skeletal muscle during sepsis
Abstract
Uncoupling protein 3 (UCP3) is a member of the mitochondrial transporter superfamily that is expressed primarily in skeletal muscle. UCP3 is upregulated in various conditions characterized by skeletal muscle atrophy, including hyperthyroidism, fasting, denervation, diabetes, cancer, lipopolysaccharide (LPS), and treatment with glucocorticoids (GCs). The influence of sepsis, another condition characterized by muscle cachexia, on UCP3 expression and activity is not known. We examined UCP3 gene and protein expression in skeletal muscles from rats after cecal ligation and puncture and from sham-operated control rats. Sepsis resulted in a two- to threefold increase in both mRNA and protein levels of UCP3 in skeletal muscle. Treatment of rats with the glucocorticoid receptor antagonist RU-38486 prevented the sepsis-induced increase in gene and protein expression of UCP3. The UCP3 mRNA and protein levels were increased 2.4- to 3.6-fold when incubated muscles from normal rats were treated with dexamethasone (DEX) and/or free fatty acids (FFA ) ex vivo. In addition, UCP3 mRNA and protein levels were significantly increased in normal rat muscles in vivo with treatment of either DEX or FFA. The results suggest that sepsis upregulates the gene and protein expression of UCP3 in skeletal muscle, which may at least in part be mediated by GCs and FFA.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
UCP3 increases in skeletal muscle of mice during acute sepsis and inflammation as well as in skeletal muscle of NTIS patients, coinciding with increased DIO2 expression.
“UCP3, which is a T3 target gene, increases in skeletal muscle of mice during acute sepsis [42] and inflammation [43] as well as in skeletal muscle of NTIS patients, coinciding with increased DIO2 expression [44].”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [42]
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
Boss, O., Samec, S., Paoloni‐Giacobino, A., Rossier, C., Dulloo, A. G., Seydoux, J., Muzzin, P., & Giacobino, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00384-0 · Cited by 1,041 · see citing works
Gong, D., He, Y., Karas, M., & Reitman, M. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24129 · Cited by 740 · see citing works
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
Clapham, J. C., Arch, J. R. S., Chapman, H., Haynes, A., Lister, C., Moore, G. B. T., Piercy, V., Carter, S. A., Lehner, I., Smith, S. A., et al. (2000) · Nature · doi:10.1038/35019082 · Cited by 604 · see citing works
Wing, S. S., & Goldberg, A. L. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.4.e668 · Cited by 345 · see citing works
Effect of sepsis on tissue adenine nucleotide levels.
Chaudry, I. H., Wichterman, K. A., & Baue, A. E. (1979) · PubMed · Cited by 329 · see citing works
Weigle, D. S., Selfridge, L. E., Schwartz, M. W., Seeley, R. J., Cummings, D. E., Havel, P. J., Kuijper, J. L., & BeltrandelRio, H. (1998) · Diabetes · doi:10.2337/diab.47.2.298 · Cited by 325 · see citing works
Samec, S., Seydoux, J., & Dulloo, A. G. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.9.715 · Cited by 305 · see citing works
Muscle Cachexia: Current Concepts of Intracellular Mechanisms and Molecular Regulation
Hasselgren, P.-O., & Fischer, J. E. (2001) · Annals of Surgery · doi:10.1097/00000658-200101000-00003 · Cited by 278 · see citing works
Self-citationBaracos, V., DeVivo, C., Hoyle, D., & Goldberg, A. (1995) · American Journal of Physiology · doi:10.1152/ajpendo.1995.268.5.e996 · Cited by 275 · see citing works
The uncoupling proteins, a review
Boss, O., Muzzin, P., & Giacobino, J.-P. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1390001 · Cited by 264 · see citing works
Tiao, G. M., Fagan, J. M., Samuels, N., James, J. H., Hudson, K., Lieberman, M. A., Fischer, J. E., & Hasselgren, P.-O. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117588 · Cited by 255 · see citing works
Self-citationEnergy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.
Tiao, G. M., Fagan, J. M., Roegner, V., Lieberman, M. A., Wang, J. J., Fischer, J. E., & Hasselgren, P. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118421 · Cited by 248 · see citing works
Self-citationUCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged
Cadenas, S., Buckingham, J. A., Samec, S., Seydoux, J., Din, N., Dulloo, A. G., & Brand, M. D. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01540-9 · Cited by 227 · see citing works
Matsuda, J., Hosoda, K., Itoh, H., Son, C., Doi, K., Tanaka, T., Fukunaga, Y., Inoue, G., Nishimura, H., Yoshimasa, Y., et al. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01381-1 · Cited by 186 · see citing works
Baracos, V. E., & Goldberg, A. L. (1986) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1986.251.4.c588 · Cited by 185 · see citing works
The Human Uncoupling Protein-3 Gene
Solanes, G., Vidal‐Puig, A., Grujić, D., Flier, J. S., & Lowell, B. B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25433 · Cited by 172 · see citing works
James, J. H., Fang, C. H., Schrantz, S. J., Hasselgren, P.-O., Paul, R. J., & Fischer, J. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119052 · Cited by 153 · see citing works
Self-citationEffects of glucocorticoids on muscle protein turnover in perfused rat hemicorpus
Rannels, S. R., & Jefferson, L. S. (1980) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1980.238.6.e564 · Cited by 147 · see citing works
Hasselgren, P., James, J. H., Benson, D. W., Hall-Angerås, M., Angerås, U., Hiyama, D. T., Li, S., & Fischer, J. E. (1989) · Metabolism · doi:10.1016/0026-0495(89)90100-5 · Cited by 146 · see citing works
Self-citationUbiquitin gene expression is increased in skeletal muscle of tumour‐bearing rats
Llovera, M., Garcia‐Martínez, C., Agell, N., Marzábal, M., López-Soriano, F. J., & Argilés, J. M. A. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80290-4 · Cited by 133 · see citing works
Medina, R., Wing, S. S., Haas, A., & Goldberg, A. L. (1991) · PubMed · Cited by 119 · see citing works
The differing responses of four muscle types to dexamethasone treatment in the rat
Kelly, F. J., & Goldspink, D. F. (1982) · Biochemical Journal · doi:10.1042/bj2080147 · Cited by 116 · see citing works
Sabina, R. L., Kernstine, K. H., Boyd, R. L., Holmes, E. W., & Swain, J. L. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34001-8 · Cited by 107 · see citing works
Glucocorticoid action on protein synthesis and protein breakdown in isolated skeletal muscles
McGrath, J. A., & Goldspink, D. F. (1982) · Biochemical Journal · doi:10.1042/bj2060641 · Cited by 106 · see citing works
Son, C., Hosoda, K., Matsuda, J., Fujikura, J., Yonemitsu, S., Iwakura, H., Masuzaki, H., Ogawa, Y., Hayashi, T., Itoh, H., et al. (2001) · Endocrinology · doi:10.1210/endo.142.10.8446 · Cited by 94 · see citing works
Hildebrandt, A. L., & Neufer, P. D. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.6.e1078 · Cited by 93 · see citing works
Regulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation
Cortright, R. N., Zheng, D., Jones, J. P., Fluckey, J. D., DiCarlo, S. E., Grujić, D., Lowell, B. B., & Dohm, G. L. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.1.e217 · Cited by 88 · see citing works
Protein expression of UCP3 differs between human type 1, type 2a, and type 2b fibers
Hesselink, M. K. C., KEIZER, H. A., Borghouts, L. B., Schaart, G., Kornips, C. F. P., Slieker, L. J., Sloop, K. W., Saris, W. H. M., & Schrauwen, P. (2001) · The FASEB Journal · doi:10.1096/fj.00-0517fje · Cited by 87 · see citing works
Huppertz, C., Fischer, B., Kim, Y., Kotani, K., Vidal‐Puig, A., Slieker, L. J., Sloop, K. W., Lowell, B. B., & Kahn, B. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011708200 · Cited by 87 · see citing works
Yu, X. X., Barger, J. L., Boyer, B. B., Brand, M. D., Pan, G., & Adams, S. H. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.2.e433 · Cited by 81 · see citing works
Konagaya, M., Bernard, P. A., & Max, S. R. (1986) · Endocrinology · doi:10.1210/endo-119-1-375 · Cited by 80 · see citing works
Purine metabolism after in vivo ischemia and reperfusion in rat skeletal muscle
Idstrom, J. P., Soussi, B., Elander, A., & Bylund‐Fellenius, A. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.258.6.h1668 · Cited by 78 · see citing works
Muscle relaxation and sarcoplasmic reticulum function in different muscle types
Dux, L. (1993) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0035274 · Cited by 76 · see citing works
Nagase, I., Yoshida, S., Cañas, X., Irie, Y., Kimura, K., Yoshida, T., & Saito, M. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01477-5 · Cited by 74 · see citing works
Skeletal muscle UCP2 and UCP3 gene expression in a rat cancer cachexia model
Sanchı́s, D., Busquets, S., Alvarez, B., Ricquier, D., López-Soriano, F. J., & Argilés, J. M. A. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01178-8 · Cited by 73 · see citing works
Effect of the glucocorticoid receptor antagonist RU 38486 on muscle protein breakdown in sepsis.
Hall-Angerås, M., Angerås, U., Zamir, O., Hasselgren, P. O., & Je, F. (1991) · PubMed · Cited by 73 · see citing works
Self-citationUp-Regulation of Uncoupling Protein-3 by Fatty Acid in C2C12 Myotubes
Hwang, C.-S., & Lane, M. D. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0662 · Cited by 72 · see citing works
Triglyceride kinetics, tissue lipoprotein lipase, and liver lipogenesis in septic rats
Lanza‐Jacoby, S., & Tabares, A. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.4.e678 · Cited by 60 · see citing works
Fischer, D., Sun, X., Gang, G., Pritts, T. A., & Hasselgren, P.-O. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1987 · Cited by 55 · see citing works
Self-citationAlterations in calcium signaling and cellular responses in septic injury.
Mm, S. (1996) · PubMed · Cited by 54 · see citing works
Jucker, B. M., Ren, J., Dufour, S., Cao, X., Previs, S. F., Cadman, K. S., & Shulman, G. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007760200 · Cited by 51 · see citing works
Contribution of skeletal muscle and adipose tissue to adrenaline-induced thermogenesis in man.
Simonsen, L., Stallknecht, B. M., & Bülow, J. (1993) · PubMed · Cited by 51 · see citing works
Schrauwen, P., Schaart, G., Saris, W. H. M., Slieker, L. J., Glatz, J. F. C., Vidal, H., & Blaak, E. E. (2000) · Diabetologia · doi:10.1007/s001250051547 · Cited by 47 · see citing works
Jimenez, M., Yvon, C., Lehr, L., Léger, B., Keller, P., Russell, A. P., Kühne, F., Flandin, P., Giacobino, J., & Muzzin, P. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02953.x · Cited by 46 · see citing works
Hasselgren, P., Hall-Angerås, M., Angerås, U., Benson, D., James, J. H., & Fischer, J. E. (1990) · Biochemical Journal · doi:10.1042/bj2670037 · Cited by 46 · see citing works
Self-citationTriacylglycerol kinetics in endotoxic rats with suppressed lipoprotein lipase activity
Bagby, G. J., Corll, C. B., & Martínez, R. (1987) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1987.253.1.e59 · Cited by 45 · see citing works
Expression and binding activity of the glucocorticoid receptor are upregulated in septic muscle
Sun, X., Fischer, D. R., Pritts, T. A., Wray, C. J., & Hasselgren, P. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00509.2001 · Cited by 42 · see citing works
Self-citationSepsis is associated with increased ubiquitinconjugating enzyme E214k mRNA in skeletal muscle
Hobler, S. C., Wang, J. J., Williams, A. B., Melandri, F. D., Sun, X., Fischer, J. E., & Hasselgren, P.-O. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.2.r468 · Cited by 37 · see citing works
Self-citationYoshitomi, H., Yamazaki, K., & Tanaka, I. (1999) · Biochemical Journal · doi:10.1042/bj3400397 · Cited by 33 · see citing works
Utilization of Exogenous Fat Emulsion (Intralipid) in Septic Rats
Chen, W. J. (1984) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860718400800114 · Cited by 27 · see citing works
Zamir, O., Hasselgren, P.-O., Frederick, J. A., & Fischer, J. E. (1992) · Journal of Pediatric Surgery · doi:10.1016/0022-3468(92)90185-a · Cited by 25 · see citing works
Self-citationFang, C., Sun, X., Li, B.-G., Fischer, D. R., Pritts, T. A., Penner, G. C., & Hasselgren, P. (2000) · Journal of Burn Care & Rehabilitation · doi:10.1097/00004630-200021060-00010 · Cited by 25 · see citing works
Self-citationInhibition of muscular amino acid release by lipid infusion in man
WICKLMAYR, M., Kristian, R. E. T. T., Schwiegelshohn, B., Wolfram, G., Hailer, S., & Dietze, G. (1987) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1987.tb02191.x · Cited by 25 · see citing works
Tissue metabolite levels in different types of skeletal muscle during sepsis
Angerås, U., Hall-Angerås, M., Wagner, K. R., James, H. J., Hasselgren, P.-O., & Fischer, J. E. (1991) · Metabolism · doi:10.1016/0026-0495(91)90208-e · Cited by 24 · see citing works
Self-citationMuscle-Specific Up-Regulation of Rat UCP3 mRNA Expression by Long-Term Hindlimb Unloading
Denjean, F., Dominique Desplanches, C., Lachuer, J., Cohen-Adad, F., Mayet, M. H., & Duchamp, C. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1847 · Cited by 13 · see citing works
Intracellular Glutamine Concentration Does Not Decrease in All Muscles during Sepsis
James, J. H., Hasselgren, P., King, J.-K., James, L. E., & Fischer, J. E. (1993) · Journal of Surgical Research · doi:10.1006/jsre.1993.1085 · Cited by 13 · see citing works
Self-citationWeanling and adult rats differ in fatty acid and carnitine metabolism during sepsis
Linz, D. N., Garcia, V. F., Arya, G., Hug, G., Tombragel, E., Landrigan, E., Chuck, G., Tsoras, M., Ryan, M. H., & Ziegler, M. M. (1995) · Journal of Pediatric Surgery · doi:10.1016/0022-3468(95)90321-6 · Cited by 10 · see citing works
Chick Skeletal Muscle Proteolysisin vitroIncreased by Corticosterone
Ohtsuka, A., Tanaka, H., HIZAKI, K., & HAYASHI, K. (1998) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.62.1781 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Beyond Low Plasma T3: Local Thyroid Hormone Metabolism during Inflammation and Infection
Boelen, A., Kwakkel, J., & Fliers, E. (2011) · Endocrine Reviews · doi:10.1210/er.2011-0007 · Cited by 287 · see citing works
An update on non-thyroidal illness syndrome
Fliers, E., & Boelen, A. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01482-4 · Cited by 199 · see citing works
The Emerging Functions of UCP2 in Health, Disease, and Therapeutics
Mattiasson, G., & Sullivan, P. G. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1 · Cited by 176 · see citing works
Sjövall, F., Morota, S., Hansson, M. J., Friberg, H., Gnaiger, E., & Elmér, E. (2010) · Critical Care · doi:10.1186/cc9337 · Cited by 139 · see citing works
Sepsis induces brain mitochondrial dysfunction.
d’Avila, J. D. C. P., Santiago, A. P. S. A., Amâncio, R. T., Galina, A., Oliveira, M. F., & Bozza, F. A. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181760c4b · Cited by 134 · see citing works
Shabalina, I. G., Joris Hoeks, J., Kramarova, T. V., Schrauwen, P., Cannon, B., & Nedergaard, J. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.02.033 · Cited by 101 · see citing works
Alamdari, N., Aversa, Z., Castillero, E., Gurav, A., Petkova, V., Tizio, S., & Hasselgren, P.-O. J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.11.154 · Cited by 97 · see citing works
Self-citationBusquets, S., Almendro, V., Barreiro, E., Figueras, M., Argilés, J. M. A., & López-Soriano, F. J. (2005) · FEBS Letters · doi:10.1016/j.febslet.2004.12.050 · Cited by 56 · see citing works
Insulin resistance in critical illness
Dhar, A. V., & Castillo, L. (2011) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e3283464b3e · Cited by 49 · see citing works
The metabolic phenotype of rodent sepsis: cause for concern?
Zolfaghari, P., Pinto, B. B., Dyson, A., & Singer, M. (2013) · Intensive Care Medicine Experimental · doi:10.1186/2197-425x-1-6 · Cited by 42 · see citing works
Aguirre, E., & Cadenas, S. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.06.009 · Cited by 40 · see citing works
Zolfaghari, P., Carré, J. E., Parker, N., Curtin, N. A., Duchen, M. R., & Singer, M. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00562.2014 · Cited by 33 · see citing works
Variation in the uncoupling protein 2 and 3 genes and human performance
Dhamrait, S. S., Williams, A. G., Day, S. H., Skipworth, J. R. A., Payne, J. R., WORLD, M. J., Humphries, S. E., & Montgomery, H. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00766.2011 · Cited by 27 · see citing works
Sepsis Impairs Thyroid Hormone Signaling and Mitochondrial Function in the Mouse Diaphragm
Bloise, F. F., Santos, A. T., Brito, J., de Andrade, C. B. V., Oliveira, T. S., Souza, A. F. P., Fontes, K. N., Silva, J. D., Blanco, N. G., Silva, P. L., et al. (2020) · Thyroid · doi:10.1089/thy.2019.0124 · Cited by 27 · see citing works
Uncoupling protein‐3 sensitizes cells to mitochondrial‐dependent stimulus of apoptosis
Dejean, L. M., Cámara, Y., Sibille, B., Solanes, G., & Villarroya, F. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20048 · Cited by 24 · see citing works
Eskilsson, A., Shionoya, K., Enerbäck, S., Engblom, D., & Blomqvist, A. G. (2020) · The FASEB Journal · doi:10.1096/fj.201902945r · Cited by 23 · see citing works
Bloise, F. F., van der Spek, A. H., Surovtseva, O. V., Ortiga-Carvalho, T. M., Fliers, E., & Boelen, A. (2016) · Thyroid · doi:10.1089/thy.2015.0536 · Cited by 21 · see citing works
Towards Comprehension of the Physiological Role of UCP3
Hesselink, M. K. C., & Schrauwen, P. (2005) · Hormone and Metabolic Research · doi:10.1055/s-2005-870421 · Cited by 19 · see citing works
MAK, R. H. K., Gunta, S. S., OLIVEIRA, E. A., & Cheung, W. W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315310 · Cited by 18 · see citing works
Sex-specific molecular genetic response to UVB exposure in Xiphophorus maculatus skin
Boswell, W. T., Boswell, M., Titus, J. K., Savage, M. G., Lü, Y., Shen, J., & Walter, R. B. (2015) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2015.07.007 · Cited by 16 · see citing works
UCP3 in muscle wasting, a role in modulating lipotoxicity?
Minnaard, R., Schrauwen, P., Schaart, G., & Hesselink, M. K. C. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.08.066 · Cited by 16 · see citing works
Kelly, O. M., McNamara, Y. M., Manzke, L. H., Meegan, M. J., & Porter, R. K. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.03.011 · Cited by 11 · see citing works
Zhang, Q., Cao, H., Astrakas, L. G., Mintzopoulos, D., Mindrinos, M. N., Schulz, J., Tompkins, R. G., Rahme, L. G., & Tzika, A. A. (2006) · International Journal of Molecular Medicine · doi:10.3892/ijmm.18.6.1223 · Cited by 10 · see citing works
Badmus, K. A., ZULKIFLI, I., Goh, Y. M., & Kamalludin, M. H. (2021) · Animals · doi:10.3390/ani11113276 · Cited by 9 · see citing works
Yao, Z., Hoffman, E. P., Ghimbovschi, S. D., DuBois, D. C., Almon, R. R., & Jusko, W. J. (2008) · Gene Regulation and Systems Biology · doi:10.4137/grsb.s613 · Cited by 5 · see citing works
Stevens, J. L., McKenna, H., Minnion, M., Murray, A. J., Feelisch, M., & Martín, D. (2025) · Experimental Biology and Medicine · doi:10.3389/ebm.2025.10254 · Cited by 1 · see citing works
Semaglutide targets muscle mitochondria to regulate glutamine metabolism and treat osteoarthritis
Tian, Y.-C., Zheng, Z., Ma, Y.-Y., Ye, F., Pang, Y.-D., Zhang, Z.-C., Li, Z., Zhang, C., & Gao, J.-J. (2026) · iScience · doi:10.1016/j.isci.2026.116347 · Cited by 1 · see citing works
TaheriChadorneshin, H., Rostamkhani, F., & Shirvani, H. (2018) · Sport Sciences for Health · doi:10.1007/s11332-018-0480-z · Cited by 1 · see citing works
Mitochondrial function in sepsis - Temporal evolvement of respiratory capacity in human blood cells
Sjövall, F. (2013) · Lund University Publications (Lund University) · Cited by 1 · see citing works
Tesi doctoral presentada per En/Na
Ironia, E. I. (2002)
Gable, D. R. (2008) · OpenGrey (Institut de l'Information Scientifique et Technique)
Universidade Federal do Rio de Janeiro Instituto de Bioquímica Médica
Nakamura, A. (2008)
Inflammatory Signaling Across the Blood-Brain Barrier and the Generation of Fever
Eskilsson, A. (2020) · Linköping University medical dissertations · doi:10.3384/diss.diva-163003
- Authors
- Sun, X., Wray, C., Tian, X., Hasselgren, P.-O., & Lu, J.
- Affiliations
- University of Cincinnati (US)
- Harvard University (US)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2003-09
- Volume
- 285
- Issue
- 3
- Pages
- E512-E520
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2086800162
- Cited by
- 36
- References
- 60
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2018: 1 · 2016: 1 · 2015: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM008478)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 37908, R01DK037908)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- UCP3, sepsis, skeletal muscle, glucocorticoids, free fatty acids, dexamethasone, mifepristone, cecal ligation and puncture, gene expression, mitochondrial uncoupling
- MeSH terms
- Uncoupling Protein 3, Animals, Cachexia, Carrier Proteins, Dexamethasone, Fatty Acids, Nonesterified, Glucocorticoids, Ion Channels, Male, RNA, Messenger, Up-Regulation, Gene Expression, Rats, Sprague-Dawley, Muscle, Skeletal, Sepsis, Mitochondrial Proteins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
