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Decreased Mitochondrial Proton Leak and Reduced Expression of Uncoupling Protein 3 in Skeletal Muscle of Obese Diet-Resistant Women

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Effects of Adenoviral Overexpression of Uncoupling Protein-2 and -3 on Mitochondrial Respiration in Insulinoma Cells**This work was supported by V.A. Medical Research Funds and NIH Grants DK-25295 and HD-29569.

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Important Trends in UCP3 Investigation

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Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance

Dulloo, A. G., Seydoux, J., & Jacquet, J. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.07.028 · Cited by 100 · see citing works

Physiological Levels of Mammalian Uncoupling Protein 2 Do Not Uncouple Yeast Mitochondria

Stuart, J. A., Harper, J. A., Brindle, K. M., Jekabsons, M. B., & Brand, M. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011566200 · Cited by 99 · see citing works

Putative function and physiological relevance of the mitochondrial uncoupling protein-3: Involvement in fatty acid metabolism?

Schrauwen, P., Joris Hoeks, J., & Hesselink, M. K. C. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.11.001 · Cited by 97 · see citing works

Sex-related differences in energy balance in response to caloric restriction.

Valle, A., Català-Niell, A., Colom, B., García-Palmer, F., Oliver, J., & Roca, P. (2005) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00553.2004 · Cited by 103 · see citing works

Thyroid hormones as molecular determinants of thermogenesis

Silvestri, E., Schiavo, L., Lombardi, A., & Goglia, F. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2005.01463.x · Cited by 94 · see citing works

The transcription factor Nrf2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress

Anedda, A., López-Bernardo, E., Acosta‐Iborra, B., Suleiman, M. S., Landázuri, M. O., & Cadenas, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.007 · Cited by 92 · see citing works

T3 increases mitochondrial ATP production in oxidative muscle despite increased expression of UCP2 and -3

Short, K. R., Nygren, J., Barazzoni, R., Levine, J. A., & Nair, K. S. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e761 · Cited by 90 · see citing works

Skeletal muscle of female rats exhibit higher mitochondrial mass and oxidative-phosphorylative capacities compared to males

Colom, B., Alcolea, M., Valle, A., Oliver, J., Roca, P., & García-Palmer, F. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000099208 · Cited by 89 · see citing works

Mitochondrial DNA alterations and reduced mitochondrial function in aging

Hebert, S. L., Lanza, I. R., & Nair, K. S. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.03.007 · Cited by 90 · see citing works

The transcriptomic signature of fasting murine liver

Sokolović, M., Sokolović, A., Wehkamp, D., van Themaat, E. V. L., de Waart, D. R., Gilhuijs-Pederson, L. A., Nikolsky, Y., van Kampen, A. H. C., Hakvoort, T. B. M., & Lamers, W. H. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-528 · Cited by 88 · see citing works

Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria

HARPER, J. A., STUART, J. A., JEKABSONS, M. B., ROUSSEL, D., BRINDLE, K. M., DICKINSON, K., JONES, R. B., & BRAND, M. D. (2002) · Biochemical Journal · doi:10.1042/bj3610049 · Cited by 87 · see citing works

Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus sungorus.

Fromme, T., Reichwald, K., Platzer, M., Li, X., & Klingenspor, M. (2007) · BMC Molecular Biology · doi:10.1186/1471-2199-8-1 · Cited by 87 · see citing works

Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning

Özcan, C., Palmeri, M., Horváth, T. L., Russell, K. S., & Russell, R. R. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00592.2012 · Cited by 86 · see citing works

Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice.

Bézaire, V., Hofmann, W. E., Kramer, J. K. G., Kozak, L. P., & Harper, M.-E. (2001) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.5.e975 · Cited by 90 · see citing works

Leptin stimulates uncoupling protein‐2 mRNA expression and Krebs cycle activity and inhibits lipid synthesis in isolated rat white adipocytes

Ceddia, R. B., William, W. N., Lima, F. B., Flandin, P., Curi, R., & Giacobino, J. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01664.x · Cited by 83 · see citing works

Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo

Hesselink, M. K. C., Greenhaff, P. L., Constantin-Teodosiu, D., Hultman, E., Saris, W. H. M., Nieuwlaat, R., Schaart, G., Kornips, E., & Schrauwen, P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16653 · Cited by 82 · see citing works

Impact of endotoxin on UCP homolog mRNA abundance, thermoregulation, and mitochondrial proton leak kinetics

Yu, X. X., Barger, J. L., Boyer, B. B., Brand, M. D., Pan, G., & Adams, S. H. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.2.e433 · Cited by 81 · see citing works

Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition

Vargas-Mendoza, N., Ángeles-Valencia, M., Morales‐González, Á., Madrigal‐Santillán, E., Morales-Martínez, M., Madrigal‐Bujaidar, E., Álvarez‐González, I., Gutiérrez‐Salinas, J., Esquivel-Chirino, C., Chamorro, G., et al. (2021) · Life · doi:10.3390/life11111269 · Cited by 83 · see citing works

Sequential changes in the signal transduction responses of skeletal muscle following food deprivation

de Lange, P., Farina, P., Moreno, M., Ragni, M., Lombardi, A., Silvestri, E., Burrone, L., Lanni, A., & Goglia, F. (2006) · The FASEB Journal · doi:10.1096/fj.06-6025fje · Cited by 78 · see citing works

Mitochondrial proton leak: a role for uncoupling proteins 2 and 3?

Porter, R. K. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00246-2 · Cited by 78 · see citing works

Superoxide and Respiratory Coupling in Mitochondria of Insulin-Deficient Diabetic Rats

Herlein, J. A., Fink, B. D., O'Malley, Y., & Sivitz, W. I. (2009) · Endocrinology · doi:10.1210/en.2008-0404 · Cited by 77 · see citing works

Possible role of avian uncoupling protein in down‐regulating mitochondrial superoxide production in skeletal muscle of fasted chickens

Abe, T., Mujahid, A., Sato, K., Akiba, Y., & Toyomizu, M. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.07.070 · Cited by 76 · see citing works

Uncoupling Protein Homologs: Emerging Views of Physiological Function

Adams, S. H. (2000) · Journal of Nutrition · doi:10.1093/jn/130.4.711 · Cited by 74 · see citing works

UCP2-dependent Proton Leak in Isolated Mammalian Mitochondria

Fink, B. D., Hong, Y.-S., Mathahs, M. M., SCHOLZ, T. D., Dillon, J. S., & Sivitz, W. I. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107955200 · Cited by 74 · see citing works

Potential involvement of mammalian and avian uncoupling proteins in the thermogenic effect of thyroid hormones

Collin, A., Cassy, S., Buyse, J. G., Decuypere, E. M. P., & Damon, M. (2005) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2005.02.007 · Cited by 74 · see citing works

Increased fatty acid oxidation in transgenic mice overexpressing UCP3 in skeletal muscle

Wang, S., Subramaniam, A., Cawthorne, M. A., & Clapham, J. C. (2003) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2003.00273.x · Cited by 74 · see citing works

Altered Skeletal Muscle Subsarcolemmal Mitochondrial Compartment During Catch-Up Fat After Caloric Restriction

Crescenzo, R., Lionetti, L., Mollica, M. P., Ferraro, M., D’Andrea, E., Mainieri, D., Dulloo, A. G., Liverini, G., & Iossa, S. (2006) · Diabetes · doi:10.2337/db06-0312 · Cited by 72 · see citing works

UCP3 protein expression is lower in type I, IIa and IIx muscle fiber types of endurance-trained compared to untrained subjects

Russell, A. P., Wadley, G. D., Hesselink, M. K. C., Schaart, G., Lo, S. K., Léger, B., GARNHAM, A. P., Moonen‐Kornips, E., Cameron‐Smith, D., Giacobino, J., et al. (2003) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-002-0943-5 · Cited by 72 · see citing works

Uncoupling Proteins: Role in Insulin Resistance and Insulin Insufficiency

B.Chan, C., & Harper, M.-E. (2006) · Current Diabetes Reviews · doi:10.2174/157339906777950660 · Cited by 71 · see citing works

Role of Uncoupling Proteins in Cancer

Valle, A., Oliver, J., & Roca, P. (2010) · Cancers · doi:10.3390/cancers2020567 · Cited by 67 · see citing works

Population Genetic Analysis of the Uncoupling Proteins Supports a Role for UCP3 in Human Cold Resistance

Hancock, A. M., Clark, V. J., Qian, Y., & Rienzo, A. D. (2010) · Molecular Biology and Evolution · doi:10.1093/molbev/msq228 · Cited by 66 · see citing works

Combined cDNA array/RT‐PCR analysis of gene expression profile in rat gastrocnemius muscle: relation to its adaptive function in energy metabolism during fasting

de Lange, P., Ragni, M., Silvestri, E., Moreno, M., Schiavo, L., Lombardi, A., Farina, P., Feola, A., Goglia, F., & Lanni, A. (2003) · The FASEB Journal · doi:10.1096/fj.03-0342fje · Cited by 66 · see citing works

Links between fatty acids and expression of UCP2 and UCP3 mRNAs

Thompson, M. P., & Kim, D. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.05.011 · Cited by 65 · see citing works

Mitochondrial uncoupling protein 3 and its role in cardiac- and skeletal muscle metabolism

Nabben, M., & Joris Hoeks, J. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.039 · Cited by 65 · see citing works

Long-term high-fat feeding induces greater fat storage in mice lacking UCP3

Costford, S. R., Chaudhry, S. N., Crawford, S. A., Salkhordeh, M., & Harper, M.-E. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00779.2007 · Cited by 64 · see citing works

Superoxide activates a GDP-sensitive proton conductance in skeletal muscle mitochondria from king penguin (Aptenodytes patagonicus)

Talbot, D. A., Hanuise, N., Rey, B., Rouanet, J., Duchamp, C., & Brand, M. D. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.022 · Cited by 64 · see citing works

Differences in proton leak kinetics, but not in UCP3 protein content, in subsarcolemmal and intermyofibrillar skeletal muscle mitochondria from fed and fasted rats

Iossa, S., Lionetti, L., Mollica, M. P., Crescenzo, R., Botta, M., Samec, S., Dulloo, A. G., & Liverini, G. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02772-7 · Cited by 24 · see citing works

The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3

Cadenas, S., Echtay, K. S., Harper, J. A., Jekabsons, M. B., Buckingham, J. A., Grau, E., Abuin, A., Chapman, H., Clapham, J. C., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109736200 · Cited by 199 · see citing works

Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria

Parker, N., Affourtit, C., Vidal‐Puig, A., & Brand, M. D. (2008) · Biochemical Journal · doi:10.1042/bj20080006 · Cited by 73 · see citing works

Absence of uncoupling protein-3 leads to greater activation of an adenine nucleotide translocase-mediated proton conductance in skeletal muscle mitochondria from calorie restricted mice

Bevilacqua, L., Seifert, E. L., Estey, C., Gerrits, M. F., & Harper, M. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.02.018 · Cited by 27 · see citing works

Acute starvation in C57BL/6J mice increases myocardial UCP2 and UCP3 protein expression levels and decreases mitochondrial bio-energetic function

Wang, C., Almsherqi, Z. A., McLachlan, C. S., Matthews, S. T., Ramachandran, M., Tay, S. K. H., & Deng, Y. (2010) · Stress · doi:10.3109/10253890.2010.506931 · Cited by 10 · see citing works