Activation of alternative NF-κB signaling during recovery of disuse-induced loss of muscle oxidative phenotype

Remels, A. H. V.; Pansters, N. A.; Gosker, H. R.; Schols, A. M. W. J.; Langen, R. C. J.

doi:10.1152/ajpendo.00452.2013

Cited by 16Muscle Physiology and DisordersSpaceflight effects on biologyAdipose Tissue and Metabolism

Activation of alternative NF-κB signaling during recovery of disuse-induced loss of muscle oxidative phenotype

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Remels, A. H. V., Pansters, N. A., Gosker, H. R., Schols, A. M. W. J., Langen, R. C. J.·2014·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00452.2013

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Abstract

Physical inactivity-induced loss of skeletal muscle oxidative phenotype (OXPHEN), often observed in chronic disease, adversely affects physical functioning and quality of life. Potential therapeutic targets remain to be identified, since the molecular mechanisms involved in reloading-induced recovery of muscle OXPHEN remain incompletely understood. We hypothesized a role for alternative NF-κB, as a recently identified positive regulator of muscle OXPHEN, in reloading-induced alterations in muscle OXPHEN. Markers and regulators (including alternative NF-κB signaling) of muscle OXPHEN were investigated in gastrocnemius muscle of mice subjected to a hindlimb suspension/reloading (HLS/RL) protocol. Expression levels of oxidative phosphorylation subunits and slow myosin heavy chain isoforms I and IIA increased rapidly upon RL. After an initial decrease upon HLS, mRNA levels of peroxisome proliferator-activated receptor (PPAR)-γ coactivator (PGC) molecules PGC-1α and PGC-1β and mRNA levels of mitochondrial transcription factor A (Tfam) and estrogen-related receptor α increased upon RL. PPAR-δ, nuclear respiratory factor 1 (NRF-1), NRF-2α, and sirtuin 1 mRNA levels increased during RL although expression levels were unaltered upon HLS. In addition, both Tfam and NRF-1 protein levels increased significantly during the RL period. Moreover, upon RL, IKK-α mRNA and protein levels increased, and phosphorylation of P100 and subsequent processing to P52 were elevated, reflecting alternative NF-κB activation. We conclude that RL-induced recovery of muscle OXPHEN is associated with activation of alternative NF-κB signaling.

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Authors: Remels, A. H. V., Pansters, N. A., Gosker, H. R., Schols, A. M. W. J., & Langen, R. C. J.
Affiliations: Maastricht University Medical Centre (NL)
Corresponding author: Remels, A. H. V.
ORCID: Gosker, H. R.
Schols, A. M. W. J.
Langen, R. C. J.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2014-03-15
Volume: 306
Issue: 6
Pages: E615-E626
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00452.2013
OpenAlex: W1980692604
Cited by: 16
References: 51
Citations by year: 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 3 · 2016: 1 · 2015: 3
FWCI: 0.55
Type: journal article
Language: en
Open access: green
cris.maastrichtuniversity.nl
Licence: other-oa
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion, other-oa)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology › Spaceflight effects on biology
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: skeletal muscle, hindlimb unloading, PGC-1α, PGC-1β, PPARδ, NRF1, Nrf2, SIRT1, p100 processing, IKKα, slow myosin heavy chain, mitochondrial biogenesis, gastrocnemius
MeSH terms: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, ERRalpha Estrogen-Related Receptor, Animals, Disease Models, Animal, DNA-Binding Proteins, Gene Expression Regulation, High Mobility Group Proteins, Immobilization, Mice, Inbred C57BL, Oxidative Phosphorylation, Random Allocation, Receptors, Estrogen, Transcription Factors, Signal Transduction, Biomarkers, NF-kappa B, Weight-Bearing, Muscle, Skeletal, Myosin Heavy Chains, Hindlimb Suspension, Muscular Disorders, Atrophic, Mitochondrial Proteins, Mice

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Activation of alternative NF-κB signaling during recovery of disuse-induced loss of muscle oxidative phenotype

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