Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases
Abstract
We previously identified a common set of genes, termed atrogenes, whose expression is coordinately induced or suppressed in muscle during systemic wasting states (fasting, cancer cachexia, renal failure, diabetes). To determine whether this transcriptional program also functions during atrophy resulting from loss of contractile activity and whether atrogene expression correlates with the rate of muscle weight loss, we used cDNA microarrays and RT‐polymerase chain reaction to analyze changes in mRNA from rat gastrocnemius during disuse atrophy induced by denervation or spinal cord isolation. Three days after Den or SI, the rate of muscle weight loss was greatest, and 78% of the atrogenes identified during systemic catabolic states were induced or repressed. Of particular interest were the large inductions of key ubiquitin ligases, atrogin‐1 (35‐to 44‐fold) and MuRF1 (12‐to 22‐fold), and the suppression of PGC‐1α and PGC‐1ᵦ coactivators (15‐fold). When atrophy slowed (day 14), the expression of 92% of these atrogenes returned toward basal levels. At 28 days, the atrophy‐inducing transcription factor, FoxO1, was still induced and may be important in maintaining the “atrophied” state. Thus, 1) the atrophy associated with systemic catabolic states and following disuse involves similar transcriptional adaptations; and 2) disuse atrophy proceeds through multiple phases corresponding to rapidly atrophying and atrophied muscles that involve distinct transcriptional patterns. Sacheck, J. M., Hyatt, J‐P. K., Raffaello, A., Jagoe, R. T., Roy, R. R., Edgerton, V. R., Lecker, S. H., Goldberg, A. L. Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases. FASEB J. 21, 140–155 (2007)
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Muscle atrophy requires activation of gene transcription programs that regulate expression of atrophy-related genes (atrogenes).
“Muscle atrophy requires the activation of gene transcription programs that regulate the expression of a subset of genes that are named atrophy-related genes or atrogenes [10–14].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [13]
Genes encoding glycolysis and oxidative phosphorylation enzymes are coordinately suppressed in atrophying muscles during denervation, disuse, diabetes, cancer, fasting, and chronic kidney disease.
“Genes encoding for glycolysis and oxidative phosphorylation enzymes are coordinately suppressed in atrophying muscles during denervation, disuse, diabetes, cancer, fasting, and chronic kidney disease [10, 11, 13, 20].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [13]
Cites
A new mathematical model for relative quantification in real-time RT-PCR
Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610 · see citing works
Church, G. M., & Gilbert, W. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.7.1991 · Cited by 8,213 · see citing works
Identification of ubiquitin ligases required for skeletal muscle atrophy.
Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521 · see citing works
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
Harding, H. P., Zhang, Y., Zeng, H., Novoa, I., Lu, P. D., Calfon, M. A., Sadri, N., Yun, C., Popko, B., Paules, R. S., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00105-9 · Cited by 3,336 · see citing works
Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00400-3 · Cited by 3,012 · see citing works
Self-citationTranscriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · see citing works
Functional Discovery via a Compendium of Expression Profiles
Hughes, T. R., Marton, M. J., Jones, A. R., Roberts, C. J., Stoughton, R. B., Armour, C. D., Bennett, H. A., Coffey, E. M., Dai, H. A., He, Y. D., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00015-5 · Cited by 2,534 · see citing works
Stitt, T. N., Drujan, D., Clarke, B. A., Panaro, F., Timofeyva, Y., Kline, W. O., Gonzalez, M., Yancopoulos, G. D., & Glass, D. J. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00211-4 · Cited by 1,964 · see citing works
Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy
Gomes, M. D., Lecker, S. H., Jagoe, R. T., Navon, A., & Goldberg, A. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251541198 · Cited by 1,774 · see citing works
Self-citationMultiple types of skeletal muscle atrophy involve a common program of changes in gene expression
Lecker, S. H., Jagoe, R. T., Gilbert, A., Gomes, M., Baracos, V., Bailey, J., Price, S. R., Mitch, W. E., & Goldberg, A. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-0610com · Cited by 1,539 · see citing works
Self-citationIKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
Cai, D., Frantz, J. D., Tawa, N. E., Melendez, P. A., Oh, B.-C., Lidov, H. G. W., Hasselgren, P.-O., Frontera, W. R., Lee, J., Glass, D. J., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.027 · Cited by 1,367 · see citing works
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1
Baar, K., Wende, A. R., Jones, T. E., Marison, M., Nolte, L. A., Chen, M., Kelly, D. P., & Holloszy, J. O. (2002) · The FASEB Journal · doi:10.1096/fj.02-0367com · Cited by 1,020 · see citing works
Sandri, M., Lin, J., Handschin, C., Yang, W., Arany, Z. P., Lecker, S. H., Goldberg, A. L., & Spiegelman, B. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607795103 · Cited by 974 · see citing works
Self-citationThe elusive function of metallothioneins
Palmiter, R. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8428 · Cited by 681 · see citing works
Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death
Perillo, N. L., Marcus, M. E., & Baum, L. G. (1998) · Journal of Molecular Medicine · doi:10.1007/s001090050232 · Cited by 640 · see citing works
Atrophy of the soleus muscle by hindlimb unweighting
Thomason, D. B., & Booth, F. W. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.68.1.1 · Cited by 631 · see citing works
Sacheck, J. M., Ohtsuka, A., McLary, S. C., & Goldberg, A. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00073.2004 · Cited by 606 · see citing works
Self-citationKamei, Y., Miura, S., SUZUKI, M. T., Kai, Y., Mizukami, J., Taniguchi, T., Mochida, K., Tomoko, H. A. T. A., Matsuda, J., Aburatani, H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400674200 · Cited by 574 · see citing works
Latres, E., Amini, A. R., Amini, A. A., Griffiths, J. S., Martin, F. J., Wei, Y., Lin, H. C., Yancopouloš, G., & Glass, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m407517200 · Cited by 514 · see citing works
Atherton, P. J., Babraj, J. A., Smith, K., Singh, J., Rennie, M. J., & Wackerhage, H. (2005) · The FASEB Journal · doi:10.1096/fj.04-2179fje · Cited by 475 · see citing works
Tumor necrosis factor-α and muscle wasting: a cellular perspective
Reid, M. B., & Li, Y. (2001) · Respiratory Research · doi:10.1186/rr67 · Cited by 458 · see citing works
Bailey, J. L., Wang, X., England, B. K., Price, S. R., Ding, X., & Mitch, W. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118566 · Cited by 455 · see citing works
Russell, A. P., Feilchenfeldt, J. W., Schreiber, S., Praz, M., Crettenand, A., Gobelet, C., Meier, C. A., Bell, D., Kralli, A., Giacobino, J., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.12.2874 · Cited by 451 · see citing works
Solomon, V., & Goldberg, A. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.43.26690 · Cited by 432 · see citing works
Self-citationMechanisms of disuse muscle atrophy: role of oxidative stress
Powers, S. K., Kavazis, A. N., & DeRuisseau, K. C. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00469.2004 · Cited by 368 · see citing works
Price, S. R., Bailey, J. L., Wang, X., Jurkovitz, C. T., England, B. K., Ding, X., Phillips, L. S., & Mitch, W. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118968 · Cited by 348 · see citing works
Patterns of gene expression in atrophying skeletal muscles: response to food deprivation
Jagoe, R. T., Lecker, S. H., Gomes, M., & Goldberg, A. L. (2002) · The FASEB Journal · doi:10.1096/fj.02-0312com · Cited by 344 · see citing works
Self-citationLiver-Specific igf-1 Gene Deletion Leads to Muscle Insulin Insensitivity
Yakar, S., Liu, J., Fernandez, A. M., Wu, Y., Schally, A. V., Frystyk, J., Chernausek, S. D., Mejía, W., & Roith, D. L. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1110 · Cited by 343 · see citing works
Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles.
Tawa, N. E., Odessey, R., & Goldberg, A. L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119513 · Cited by 322 · see citing works
Self-citationProtein Turnover in Skeletal Muscle
Goldberg, A. L. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93117-0 · Cited by 320 · see citing works
Self-citationSpherical reflector as an electromagnetic-missile launcher
Shen, H.-M. (1990) · Journal of Applied Physics · doi:10.1063/1.347115 · Cited by 307 · see citing works
Furuno, K., Goodman, M. N., & Goldberg, A. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38923-9 · Cited by 300 · see citing works
Self-citationGlucocorticoids and muscle catabolism
Hasselgren, P.-O. (1999) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-199905000-00002 · Cited by 297 · see citing works
Medina, R., Wing, S. S., & Goldberg, A. L. (1995) · Biochemical Journal · doi:10.1042/bj3070631 · Cited by 294 · see citing works
Self-citationEffects of food deprivation on protein synthesis and degradation in rat skeletal muscles
Li, J., & Goldberg, A. (1976) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1976.231.2.441 · Cited by 288 · see citing works
Self-citationAdams, G. R., & Haddad, F. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.6.2509 · Cited by 287 · see citing works
Activation of an alternative NF‐ΚB pathway in skeletal muscle during disuse atrophy
Hunter, R. B., Stevenson, E. J., Koncarevic, A., Mitchell-Felton, H., Essig, D. A., & Kandarian, S. C. (2002) · The FASEB Journal · doi:10.1096/fj.01-0866com · Cited by 281 · see citing works
Baracos, V., DeVivo, C., Hoyle, D., & Goldberg, A. (1995) · American Journal of Physiology · doi:10.1152/ajpendo.1995.268.5.e996 · Cited by 275 · see citing works
Self-citationGlobal analysis of gene expression patterns during disuse atrophy in rat skeletal muscle
Stevenson, E. J., Giresi, P. G., Koncarevic, A., & Kandarian, S. C. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00033.x · Cited by 270 · see citing works
PGC-1α mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle
Norrbom, J., Sundberg, C. J., Rundqvist, H., Kraus, W. E., Jansson, E., & Gustafsson, T. P. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00765.2003 · Cited by 263 · see citing works
Identification of a molecular signature of sarcopenia
Giresi, P. G., Stevenson, E. J., Theilhaber, J., Koncarevic, A., Parkington, J. D., Fielding, R. A., & Kandarian, S. C. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00249.2004 · Cited by 263 · see citing works
Evaluation of signals activating ubiquitin-proteasome proteolysis in a model of muscle wasting
Mitch, W. E., Bailey, J. L., Wang, X., Jurkovitz, C. T., Newby, D. E., & Price, S. R. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.5.c1132 · Cited by 237 · see citing works
Ladner, K. J., Caligiuri, M. A., & D, D. C. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207129200 · Cited by 233 · see citing works
Wing, S. S., Haas, A. L., & Goldberg, A. L. (1995) · Biochemical Journal · doi:10.1042/bj3070639 · Cited by 222 · see citing works
Self-citationProtein Turnover in Skeletal Muscle
Goldberg, A. L. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93116-9 · Cited by 221 · see citing works
Self-citationSepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle
Wray, C. J., Mammen, J. M. V., Hershko, D., & Hasselgren, P. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00341-2 · Cited by 218 · see citing works
Phan, J., Péterfy, M., & Reue, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403506200 · Cited by 205 · see citing works
Protein metabolism and beta-myosin heavy-chain mRNA in unweighted soleus muscle
Thomason, D. B., Biggs, R. B., & Booth, F. W. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.257.2.r300 · Cited by 201 · see citing works
Denervation supersensitivity in skeletal muscle: analysis with a cloned cDNA probe.
Merlie, J. P., Isenberg, K. E., Russell, S. D., & Sanes, J. R. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.99.1.332 · Cited by 190 · see citing works
Lecker, S. H., Solomon, V., Price, S. R., Kwon, Y. T., Mitch, W. E., & Goldberg, A. L. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7300 · Cited by 178 · see citing works
Self-citationMarszalek, J. R., Weiner, J. A., Farlow, S. J., Chun, J. J. M., & Goldstein, L. S. B. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.3.469 · Cited by 167 · see citing works
Atrophy responses to muscle inactivity. II. Molecular markers of protein deficits
Haddad, F., Roy, R. R., Zhong, H., Edgerton, V. R., & Baldwin, K. M. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01113.2002 · Cited by 164 · see citing works
Self-citationSchulze, P. C., Fang, J. S., Kassik, K. A., Gannon, J., Cupesi, M., MacGillivray, C., Lee, R. T., & Rosenthal, N. A. (2005) · Circulation Research · doi:10.1161/01.res.0000179580.72375.c2 · Cited by 133 · see citing works
Hyatt, J. K., Roy, R. R., Baldwin, K. M., & Edgerton, V. R. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00128.2003 · Cited by 127 · see citing works
Self-citationAltered responses in skeletal muscle protein turnover during aging in anabolic and catabolic periods
Attaix, D., Mosoni, L., Dardevet, D., Combaret, L., Mirand, P. P., & Grizard, J. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.04.009 · Cited by 123 · see citing works
Adams, L., Carlson, B. M., Henderson, L., & Goldman, D. J. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.5.1341 · Cited by 123 · see citing works
Marino, J. H., Cook, P., & Miller, K. S. (2003) · Journal of Immunological Methods · doi:10.1016/s0022-1759(03)00103-0 · Cited by 116 · see citing works
A possible role for glucocorticoids in denervation atrophy
DuBois, D. C., & Almon, R. R. (1981) · Muscle & Nerve · doi:10.1002/mus.880040504 · Cited by 114 · see citing works
Bey, L., Akunuri, N., Zhao, P., Hoffman, E. P., Hamilton, D. G., & Hamilton, M. T. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00001.2002 · Cited by 106 · see citing works
Trace element movement and oxidative stress in skeletal muscle atrophied by immobilization
Kondo, H., Miura, M., Nakagaki, I., Sasaki, S., & Itokawa, Y. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.5.e583 · Cited by 102 · see citing works
Tupling, A. R., Asahi, M., & MacLennan, D. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206171200 · Cited by 98 · see citing works
Function and structure in the chronically isolated lumbo‐sacral spinal cord of the dog
Tower, S. S. (1937) · The Journal of Comparative Neurology · doi:10.1002/cne.900670107 · Cited by 95 · see citing works
Tischler, M. E., Rosenberg, S. B., Satarug, S., Henriksen, E. J., Kirby, C. R., Tome, M. E., & Chase, P. (1990) · Metabolism · doi:10.1016/0026-0495(90)90113-q · Cited by 94 · see citing works
Cell proliferation in denervated muscle: Identity and origin of dividing cells
Murray, M. A., & Robbins, N. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90040-9 · Cited by 93 · see citing works
Novel aspects on the regulation of muscle wasting in sepsis
Hasselgren, P.-O., Menconi, M. J., Fareed, M. U., Yang, H., Wei, W., & Evenson, A. R. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.01.017 · Cited by 85 · see citing works
P311 induces a TGF-β1–independent, nonfibrogenic myofibroblast phenotype
Pan, D., Zhe, X., Jakkaraju, S., Taylor, G. A., & Schuger, L. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15614 · Cited by 79 · see citing works
Metallothionein in human disease.
Simpkins, C. (2000) · PubMed · Cited by 78 · see citing works
Raffaello, A., Laveder, P., Romualdi, C., Bean, C., Toniolo, L., Germinario, E., Megighian, A., Danieli‐Betto, D., Reggiani, C., & Lanfranchi, G. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00051.2005 · Cited by 73 · see citing works
Self-citationDenervation‐induced alterations in gene expression in mouse skeletal muscle
Magnusson, C., Svensson, A., Christerson, U., & Tågerud, S. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03855.x · Cited by 65 · see citing works
Temporal effects of inactivty on myosin heavy chain gene expression in rat slow muscle
Huey, K. A., Roy, R. R., Baldwin, K. M., & Edgerton, V. R. (2001) · Muscle & Nerve · doi:10.1002/mus.1035 · Cited by 62 · see citing works
Self-citationFischer, D., Sun, X., Gang, G., Pritts, T. A., & Hasselgren, P.-O. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1987 · Cited by 55 · see citing works
Gardiner, P. F., Hibl, B., Simpson, D. R., Roy, R. R., & Edgerton, V. R. (1980) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00588695 · Cited by 51 · see citing works
Self-citationMechanical properties of the electrically silent adult rat soleus muscle
Roy, R. R., Zhong, H., Monti, R. J., Vallance, K. A., & Edgerton, V. R. (2002) · Muscle & Nerve · doi:10.1002/mus.10219 · Cited by 45 · see citing works
Self-citationRole of glucocorticoids in the response of rat leg muscles to reduced activity
Jaspers, S. R., & Tischler, M. E. (1986) · Muscle & Nerve · doi:10.1002/mus.880090613 · Cited by 39 · see citing works
Regulation of TG-interacting factor by transforming growth factor-beta
Feifei, C. H. E. N., Ogawa, K., Nagarajan, R. P., Zhang, M., Kuang, C., & Chen, Y. (2003) · Biochemical Journal · doi:10.1042/bj20030095 · Cited by 31 · see citing works
Neuromyotonia in mice with hereditary myelinopathies
Zielasek, J., Martini, R., Suter, U., & Toyka, K. V. (2000) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(200005)23:5 · Cited by 30 · see citing works
Self-citationThe effect of endotoxin on skeletal muscle protein gene expression in the rat
Macallan, D. C., Eb, C., Preedy, V. R., & Griffin, G. E. (1996) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/1357-2725(95)00170-0 · Cited by 18 · see citing works
Price, S. R., Jl, B., & Bk, E. (1996) · PubMed · Cited by 17 · see citing works
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Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953 · see citing works
Self-citationRapid Disuse Atrophy of Diaphragm Fibers in Mechanically Ventilated Humans
Levine, S., Nguyen, T., Taylor, N. E., Friscia, M. E., Budak, M. T., Rothenberg, P., Zhu, J., Sachdeva, R., Sonnad, S. S., Kaiser, L. R., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa070447 · Cited by 1,580 · see citing works
Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.004 · Cited by 1,489 · see citing works
Self-citationMechanisms regulating skeletal muscle growth and atrophy
Schiaffino, S., Dyar, K. A., Ciciliot, S., Blaauw, B., & Sandri, M. (2013) · The FEBS Journal · doi:10.1111/febs.12253 · Cited by 1,492 · see citing works
Cellular and molecular mechanisms of muscle atrophy
Bonaldo, P., & Sandri, M. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.010389 · Cited by 1,284 · see citing works
Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1
Bodine, S. C., & Baehr, L. M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00204.2014 · Cited by 1,117 · see citing works
Muscle wasting in disease: molecular mechanisms and promising therapies
Cohen, S., Nathan, J. A., & Goldberg, A. L. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4467 · Cited by 1,089 · see citing works
Self-citationSandri, M., Lin, J., Handschin, C., Yang, W., Arany, Z. P., Lecker, S. H., Goldberg, A. L., & Spiegelman, B. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607795103 · Cited by 974 · see citing works
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Sandri, M. (2008) · Physiology · doi:10.1152/physiol.00041.2007 · Cited by 830 · see citing works
Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size
Trendelenburg, A. U., Meyer, A., Rohner, D., Boyle, J., Hatakeyama, S., & Glass, D. J. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00105.2009 · Cited by 792 · see citing works
Milan, G., Romanello, V., Pescatore, F., Armani, A., Paik, J.-H., Frasson, L., Seydel, A., Zhao, J., Abraham, R., Goldberg, A. L., et al. (2015) · Nature Communications · doi:10.1038/ncomms7670 · Cited by 709 · see citing works
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Ciciliot, S., Rossi, C. A., Dyar, K. A., Blaauw, B., & Schiaffino, S. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.05.016 · Cited by 626 · see citing works
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Romanello, V., Guadagnin, E., Gomes, L., Roder, I., Sandri, C., Petersen, Y., Milan, G., Masiero, E., Del Piccolo, P., Foretz, M., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.60 · Cited by 596 · see citing works
Cohen, S., Brault, J. J., Gygi, S. P., Glass, D. J., Valenzuela, D. M., Gartner, C. A., Latres, E., & Goldberg, A. L. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200901052 · Cited by 584 · see citing works
Self-citationThe role of FoxO in the regulation of metabolism
Gross, D. N., van den Heuvel, A. P. J., & Birnbaum, M. J. (2008) · Oncogene · doi:10.1038/onc.2008.25 · Cited by 555 · see citing works
Smad2 and 3 transcription factors control muscle mass in adulthood
Sartori, R., Milan, G., Patron, M., Mammucari, C., Blaauw, B., Abraham, R., & Sandri, M. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00104.2009 · Cited by 517 · see citing works
Autophagy in health and disease: A comprehensive review
Saha, S., Panigrahi, D. P., Patil, S., & Bhutia, S. K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.007 · Cited by 514 · see citing works
BMP signaling controls muscle mass
Sartori, R., Schirwis, E., Blaauw, B., Bortolanza, S., Zhao, J., Enzo, E., Stantzou, A., Mouisel, E., Toniolo, L., Ferry, A., et al. (2013) · Nature Genetics · doi:10.1038/ng.2772 · Cited by 467 · see citing works
Self-citationSandri, M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.056 · Cited by 451 · see citing works
Myogenin and Class II HDACs Control Neurogenic Muscle Atrophy by Inducing E3 Ubiquitin Ligases
Moresi, V., Williams, A. H., Meadows, E., Flynn, J. M., Potthoff, M. J., McAnally, J., Shelton, J. M., Backs, J., Klein, W. H., Richardson, J. A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.004 · Cited by 445 · see citing works
Cancer cachexia: Developing multimodal therapy for a multidimensional problem
Fearon, K. C. H. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.02.033 · Cited by 444 · see citing works
Mitochondrial quality control and muscle mass maintenance.
Romanello, V., & Sandri, M. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2015.00422 · Cited by 434 · see citing works
Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting
Tintignac, L. A. J., Brenner, H.-R., & Rüegg, M. A. (2015) · Physiological Reviews · doi:10.1152/physrev.00033.2014 · Cited by 422 · see citing works
Glover, E. I., Phillips, S. M., Oates, B. R., Tang, J. E., Tarnopolsky, M. A., Selby, A., Smith, K., & Rennie, M. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.160333 · Cited by 414 · see citing works
Joseph, A., Adhihetty, P. J., Buford, T. W., Wohlgemuth, S. E., Lees, H. A., Nguyen, L. M. ‐., Aranda, J. M., Sandesara, B. D., Pahor, M., Manini, T. M., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00844.x · Cited by 395 · see citing works
Villena, J. A. (2014) · FEBS Journal · doi:10.1111/febs.13175 · Cited by 404 · see citing works
Bodine, S. C. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.011 · Cited by 392 · see citing works
The impact of extended bed rest on the musculoskeletal system in the critical care environment
Parry, S. M., & Puthucheary, Z. A. (2015) · Extreme Physiology & Medicine · doi:10.1186/s13728-015-0036-7 · Cited by 383 · see citing works
Atrogin-1, MuRF-1, and sarcopenia
Gumucio, J. P., & Mendias, C. L. (2012) · Endocrine · doi:10.1007/s12020-012-9751-7 · Cited by 368 · see citing works
Kunkel, S. D., Suneja, M., Ebert, S. M., Bongers, K. S., Fox, D. K., Malmberg, S. E., Alipour, F., Shields, R. K., & Adams, C. M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.020 · Cited by 345 · see citing works
“As discussed above, atrogin-1 and MuRF1 are transcriptionally upregulated by atrophy-inducing stresses (Sacheck et al., 2007; and Figure 1B), and they are required for muscle atrophy (Bodine et al., 2001a).”
Boer, M. D. D., Selby, A., Atherton, P. J., Smith, K., Seynnes, O., Maganaris, C. N., Maffulli, N., Movin, T., Narici, M. V., & Rennie, M. J. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.142828 · Cited by 344 · see citing works
Lagirand-Cantaloube, J., Offner, N., Csibi, A., Leibovitch, M.-P., Batonnet‐Pichon, S., Tintignac, L. A. J., Segura, C. T., & Leibovitch, S. A. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.52 · Cited by 328 · see citing works
Alterations of protein turnover underlying disuse atrophy in human skeletal muscle
Phillips, S. M., Glover, E. I., & Rennie, M. J. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00452.2009 · Cited by 322 · see citing works
Myostatin/activin pathway antagonism: molecular basis and therapeutic potential
Han, H. Q., Zhou, X., Mitch, W. E., & Goldberg, A. L. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.05.019 · Cited by 314 · see citing works
Self-citationBuford, T. W., Anton, S. D., Judge, A. R., Marzetti, E., Wohlgemuth, S. E., Carter, C. S., Leeuwenburgh, C., Pahor, M., & Manini, T. M. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.004 · Cited by 295 · see citing works
Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle
Mammucari, C., Schiaffino, S., & Sandri, M. (2008) · Autophagy · doi:10.4161/auto.5905 · Cited by 295 · see citing works
The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity
Hanai, J., Cao, P., Tanksale, P., Imamura, S., Koshimizu, E., Zhao, J., Kishi, S., Yamashita, M., Phillips, P. S., Sukhatme, V. P., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32741 · Cited by 281 · see citing works
Self-citationThe regulation of muscle mass by endogenous glucocorticoids
Braun, T. P., & Marks, D. L. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00012 · Cited by 273 · see citing works
Muscle Atrophy Induced by Mechanical Unloading: Mechanisms and Potential Countermeasures
Gao, Y., Arfat, Y., Wang, H., & Goswami, N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00235 · Cited by 275 · see citing works
Ibebunjo, C., Chick, J. M., Kendall, T., Eash, J. K., Li, C., Zhang, Y., Vickers, C., Wu, Z., Clarke, B. A., Shi, J., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01036-12 · Cited by 267 · see citing works
Costa, A., Toschi, A., Murfuni, I., Pelosi, L., Sica, G., Adamo, S., & Scicchitano, B. M. (2014) · BioMed Research International · doi:10.1155/2014/235426 · Cited by 247 · see citing works
PGC-1 coactivators and skeletal muscle adaptations in health and disease
Arany, Z. P. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.07.018 · Cited by 244 · see citing works
Stress-induced Skeletal Muscle Gadd45a Expression Reprograms Myonuclei and Causes Muscle Atrophy
Ebert, S. M., Dyle, M. C., Kunkel, S. D., Bullard, S. A., Bongers, K. S., Fox, D. K., Dierdorff, J. M., Foster, E. D., & Adams, C. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.374777 · Cited by 221 · see citing works
Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength
Palla, A. R., Ravichandran, M., Wang, Y. X., Alexandrova, L., Yang, A. V., Kraft, P., Holbrook, C. A., Schürch, C. M., Ho, A. T. V., & Blau, H. M. (2021) · Science · doi:10.1126/science.abc8059 · Cited by 232 · see citing works
Doyle, A., Zhang, G., Fattah, E. A. A., Eissa, N. T., & Li, Y. (2011) · The FASEB Journal · doi:10.1096/fj.10-164152 · Cited by 256 · see citing works
Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids
Baehr, L. M., Furlow, J. D., & Bodine, S. C. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.212845 · Cited by 234 · see citing works
Altun, M., Besche, H. C., Overkleeft, H. S., Piccirillo, R., Edelmann, M. J., Kessler, B. M., Goldberg, A. L., & Ulfhake, B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.129718 · Cited by 226 · see citing works
Self-citationSex Differences in Muscle Wasting
Anderson, L. J., Liu, H. M., & Garcia, J. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_9 · Cited by 222 · see citing works
Cannavino, J., Brocca, L., Sandri, M., Bottinelli, R., & Pellegrino, M. A. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.275545 · Cited by 220 · see citing works
Brault, J. J., Jespersen, J. G., & Goldberg, A. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.113092 · Cited by 217 · see citing works
Self-citationSignaling Pathways That Control Muscle Mass
Vainshtein, A., & Sandri, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134759 · Cited by 213 · see citing works
Braun, T. P., Zhu, X., Szumowski, M., Scott, G. D., Grossberg, A. J., Levasseur, P. R., Graham, K., Khan, S., Damaraju, S., Colmers, W. F., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20111020 · Cited by 213 · see citing works
Lee, D., & Goldberg, A. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.489716 · Cited by 211 · see citing works
Self-citationCohen, S., Zhai, B., Gygi, S. P., & Goldberg, A. L. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201110067 · Cited by 205 · see citing works
Self-citationThe microRNA miR-696 regulates PGC-1α in mouse skeletal muscle in response to physical activity
Aoi, W., Naito, Y., Mizushima, K., Takanami, Y., Kawai, Y., Ichikawa, H., & Yoshikawa, T. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00448.2009 · Cited by 206 · see citing works
Age-related changes in skeletal muscle: changes to life-style as a therapy
McCormick, R., & Vasilaki, A. (2018) · Biogerontology · doi:10.1007/s10522-018-9775-3 · Cited by 210 · see citing works
Muscle metabolism and atrophy: let’s talk about sex
Rosa-Caldwell, M. E., & Greene, N. P. (2019) · Biology of Sex Differences · doi:10.1186/s13293-019-0257-3 · Cited by 202 · see citing works
Wada, S., Kato, Y., Okutsu, M., Miyaki, S., Suzuki, K., Yan, Z., Schiaffino, S., Asahara, H., Ushida, T., & Akimoto, T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.271270 · Cited by 200 · see citing works
Romanello, V., & Sandri, M. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03662-0 · Cited by 197 · see citing works
FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70.
Senf, S. M., Dodd, S., & Judge, A. (2010) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.00315.2009 · Cited by 208 · see citing works
Brocca, L., Cannavino, J., Coletto, L., Biolo, G., Sandri, M., Bottinelli, R., & Pellegrino, M. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.240267 · Cited by 190 · see citing works
Baumert, P., Lake, M., Stewart, C. E., Drust, B., & Erskine, R. M. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3411-1 · Cited by 194 · see citing works
Abadi, A., Glover, E. I., Isfort, R. J., Raha, S., Safdar, A., Yasuda, N., Kaczor, J. J., Melov, S., Hubbard, A., Qu, X., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006518 · Cited by 189 · see citing works
Bone and muscle loss after spinal cord injury: organ interactions
Qin, W., Bauman, W. A., & Cardozo, C. P. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05806.x · Cited by 189 · see citing works
Nakao, R., Hirasaka, K., Goto, J., Ishidoh, K., Yamada, C., Ohno, A., Okumura, Y., Nonaka, I., Yasutomo, K., Baldwin, K. M., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01347-08 · Cited by 188 · see citing works
Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass
Goodman, C. A., Mayhew, D. L., & Hornberger, T. A. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.07.013 · Cited by 178 · see citing works
Raue, U., Slivka, D. R., Jemioło, B., Hollon, C. J., & Trappe, S. W. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.12.1407 · Cited by 172 · see citing works
Fredriksson, K., Tjäder, I., Keller, P., Petrovič, N., Ahlman, B. H. J., Scheele, C. C., Wernerman, J., Timmons, J. A., & Rooyackers, O. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003686 · Cited by 168 · see citing works
FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy
O’Neill, B. T., Bhardwaj, G., Penniman, C. M., Krumpoch, M. T., Suarez Beltran, P. A., Klaus, K., Poro, K., Li, M., Pan, H., Dreyfuss, J. M., et al. (2019) · Diabetes · doi:10.2337/db18-0416 · Cited by 167 · see citing works
Atherton, P. J., Greenhaff, P. L., Phillips, S. M., Bodine, S. C., Adams, C. M., & Lang, C. H. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00257.2016 · Cited by 166 · see citing works
Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor
Zhao, J., Brault, J. J., Schild, A., & Goldberg, A. L. (2008) · Autophagy · doi:10.4161/auto.5633 · Cited by 164 · see citing works
Self-citationUnravelling the mechanisms regulating muscle mitochondrial biogenesis
Hood, D. A., Tryon, L. D., Carter, H. N., Kim, Y., & Chen, C. C. W. (2016) · Biochemical Journal · doi:10.1042/bcj20160009 · Cited by 159 · see citing works
JunB transcription factor maintains skeletal muscle mass and promotes hypertrophy
Raffaello, A., Milan, G., Masiero, E., Carnio, S., Lee, D., Lanfranchi, G., Goldberg, A. L., & Sandri, M. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201001136 · Cited by 156 · see citing works
Self-citationAging Affects the Transcriptional Regulation of Human Skeletal Muscle Disuse Atrophy
Suetta, C., Frandsen, U., Jensen, L., Jensen, M. M., Jespersen, J. G., Hvid, L. G., Bayer, M. L., Petersson, S. J., Schrøder, H. D., Andersen, J. L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051238 · Cited by 160 · see citing works
Baldwin, K., Haddad, F., Pandorf, C., Roy, R. R., & Edgerton, V. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00284 · Cited by 113 · see citing works
Self-citationEffect of Prehabilitation on the Outcome of Anterior Cruciate Ligament Reconstruction
Shaarani, S. R., O’Hare, C., Quinn, A., Moyna, N. M., Moran, R., & O’Byrne, J. (2013) · The American Journal of Sports Medicine · doi:10.1177/0363546513493594 · Cited by 160 · see citing works
Involvement of MicroRNAs in the Regulation of Muscle Wasting during Catabolic Conditions
Soares, R., Cagnin, S., Chemello, F., Silvestrin, M., Musarò, A., Pittà, C. D., Lanfranchi, G., & Sandri, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.561845 · Cited by 155 · see citing works
A Review of the Pharmacological Properties of Psoralen
Ren, Y., Song, X., Tan, L., Guo, C., Wang, M., Liu, H., Cao, Z., Li, Y., & Peng, C. Y. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.571535 · Cited by 158 · see citing works
Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs
Bowman, C. J., Ayer, D. E., & Dynlacht, B. D. (2014) · Nature Cell Biology · doi:10.1038/ncb3062 · Cited by 153 · see citing works
Mechanisms of skeletal muscle aging: insights from <i>Drosophila</i> and mammalian models
Demontis, F., Piccirillo, R., Goldberg, A. L., & Perrimon, N. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.012559 · Cited by 238 · see citing works
Self-citationCellular and molecular events controlling skeletal muscle mass in response to altered use
Favier, F. B., Benoit, H., & Freyssenet, D. G. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0423-z · Cited by 149 · see citing works
Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass
Sakuma, K., & Yamaguchi, A. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-011-0052-4 · Cited by 137 · see citing works
Mechanisms of muscle growth and atrophy in mammals and Drosophila
Piccirillo, R., Demontis, F., Perrimon, N., & Goldberg, A. L. (2013) · Developmental Dynamics · doi:10.1002/dvdy.24036 · Cited by 145 · see citing works
Self-citationHudson, M. B., Woodworth-Hobbs, M. E., Zheng, B., Rahnert, J. A., Blount, M. A., Gooch, J. L., Searles, C. D., & Price, S. R. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00266.2013 · Cited by 137 · see citing works
Dyle, M. C., Ebert, S. M., Cook, D. P., Kunkel, S. D., Fox, D. K., Bongers, K. S., Bullard, S. A., Dierdorff, J. M., & Adams, C. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.556241 · Cited by 138 · see citing works
Autophagy in health and disease. 3. Involvement of autophagy in muscle atrophy
Sandri, M. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00531.2009 · Cited by 152 · see citing works
C/EBPβ mediates tumour‐induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting
Zhang, G., Jin, B., & Li, Y. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.292 · Cited by 136 · see citing works
Sáinz, N., Rodríguez, A., Catalán, V., Becerril, S., Ramírez, B., Gómez-Ambrosi, J., & Frühbeck, G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006808 · Cited by 135 · see citing works
Effects of 3 days unloading on molecular regulators of muscle size in humans
Gustafsson, T. P., Österlund, T., Flanagan, J. N., von Walden, F., Trappe, T. A., Linnehan, R. M., & Tesch, P. A. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00110.2009 · Cited by 132 · see citing works
Wollersheim, T., Woehlecke, J., Krebs, M., Hamati, J., Lodka, D., Luther-Schroeder, A., Langhans, C., Haas, K., Radtke, T., Kleber, C., et al. (2014) · Intensive Care Medicine · doi:10.1007/s00134-014-3224-9 · Cited by 143 · see citing works
A centronuclear myopathy-dynamin 2 mutation impairs skeletal muscle structure and function in mice
Durieux, A., Vignaud, A., Prudhon, B., Bui, M. T., Beuvin, M., Vassilopoulos, S., Fraysse, B., Ferry, A., Lainé, J., Romero, N. B., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq413 · Cited by 131 · see citing works
The Transcription Factor ATF4 Promotes Skeletal Myofiber Atrophy during Fasting
Ebert, S. M., Monteys, A. M., Fox, D. K., Bongers, K. S., Shields, B. E., Malmberg, S. E., Davidson, B. L., Suneja, M., & Adams, C. M. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0345 · Cited by 130 · see citing works
HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy
Beharry, A. W., Sandesara, P. B., Roberts, B. M., Ferreira, L. F., Senf, S. M., & Judge, A. R. (2014) · Journal of Cell Science · doi:10.1242/jcs.136390 · Cited by 128 · see citing works
Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic Apc Min/+ mouse
Baltgalvis, K. A., Berger, F. G., Peña, M. M. O., Davis, J. M., White, J. P., & Carson, J. A. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0574-6 · Cited by 125 · see citing works
Coffey, V. G., Jemiolo, B., Edge, J., Garnham, A. P., Trappe, S. W., & Hawley, J. A. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00351.2009 · Cited by 120 · see citing works
Quy, P. N., Kuma, A., Pierre, P., & Mizushima, N. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.399949 · Cited by 118 · see citing works
White, Z. R., Terrill, J. R., White, R. B., McMahon, C., Sheard, P., Grounds, M. D., & Shavlakadze, T. (2016) · Skeletal Muscle · doi:10.1186/s13395-016-0117-3 · Cited by 119 · see citing works
Metabolic benefits of resistance training and fast glycolytic skeletal muscle
LeBrasseur, N. K., Walsh, K. X., & Arany, Z. P. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00512.2010 · Cited by 119 · see citing works
Fox, D. K., Ebert, S. M., Bongers, K. S., Dyle, M. C., Bullard, S. A., Dierdorff, J. M., Kunkel, S. D., & Adams, C. M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00010.2014 · Cited by 119 · see citing works
Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle
Coffey, V. G., Pilegaard, H., Garnham, A. P., O'Brien, B. J., & Hawley, J. A. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91221.2008 · Cited by 116 · see citing works
- Authors
- Sacheck, J. M., Hyatt, J. K., Raffaello, A., Thomas Jagoe, R., Roy, R. R., Reggie Edgerton, V., Lecker, S. H., & Goldberg, A. L.
- Affiliations
- Harvard University (US)
- Georgetown University (US)
- Pulmonary and Rehabilitation Research Group, Department of Medicine University Hospital Aintree Liverpool UK
- University of California, Los Angeles (US)
- Department of Physiological Sciences and Brain Research Institute University of California Los Angeles California USA
- Beth Israel Deaconess Medical Center (US)
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2006-11-20
- Volume
- 21
- Issue
- 1
- Pages
- 140-155
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2014899456
- Cited by
- 585
- References
- 80
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 13 · 2023: 21 · 2022: 22 · 2021: 25 · 2020: 33 · 2019: 31 · 2018: 30 · 2017: 28 · 2016: 30 · 2015: 36 · 2014: 43 · 2013: 40 · 2012: 50
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- National Institutes of Health (NS16333, DK6230701)
- Muscular Dystrophy Association
- National Space Biomedical Research Institute
- Lawrence Ellison Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Keywords
- muscle atrophy, disuse atrophy, denervation, atrogenes, ubiquitin ligase, atrogin-1, MuRF1, PGC-1α, PGC-1β, FOXO1, gastrocnemius, transcriptional regulation
- MeSH terms
- Animals, Cachexia, Denervation, Female, Humans, Transcription, Genetic, Blotting, Northern, Rats, Sprague-Dawley, Muscle, Skeletal, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Rats
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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