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Proton magnetic resonance spectroscopy shows lower intramyocellular lipid accumulation in middle-aged subjects predisposed to familial longevity
Abstract
Families predisposed to longevity show enhanced glucose tolerance and skeletal muscle insulin sensitivity compared with controls, independent of body composition and physical activity. Intramyocellular lipid (IMCL) accumulation in skeletal muscle has been associated with insulin resistance. Here, we assessed whether subjects enriched for familial longevity have lower IMCL levels. We determined IMCL levels in 48 subjects from the Leiden Longevity Study, comprising 24 offspring of nonagenarian siblings and 24 partners thereof as control subjects. IMCL levels were assessed noninvasively using short echo time proton magnetic resonance spectroscopy ((1)H-MRS) of the tibialis anterior muscle with a 7 Tesla human MR scanner. IMCL levels were calculated relative to the total creatine (tCr) CH3 signal. Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ). After correction for age, sex, BMI, and physical activity, offspring of long-lived nonagenarian siblings tended to show lower IMCL levels compared with controls (IMCL/tCr: 3.1 ± 0.5 vs. 4.5 ± 0.5, respectively, P = 0.051). In a pairwise comparison, this difference reached statistical significance (P = 0.038). We conclude that offspring of nonagenarian siblings predisposed to longevity show lower IMCL levels compared with environmentally matched control subjects. Future research should focus on assessing what mechanisms may explain the lower IMCL levels in familial longevity.
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Offspring of Caucasian nonagenarian siblings predisposed to longevity had lower myosteatosis compared to matched controls.
“This study revealed that offspring of Caucasian nonagenarian siblings predisposed to longevity had lower myosteatosis compared to matched controls.”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Wijsman et al., 2012
Myosteatosis is a novel marker of impaired survival.
“As first suggested by the Leiden Longevity Study, myosteatosis is a novel marker of impaired survival (Wijsman et al., 2012).”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Wijsman et al., 2012
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Metadata
- Authors
- Wijsman, C. A., van Opstal, A. M., Kan, H. E., Maier, A. B., Westendorp, R. G. J., Slagboom, P. E., Webb, A. G., Mooijaart, S. P., & van Heemst, D.
- Affiliations
- Department of Gerontology and Geriatrics;
- C. J. Gorter Center for High Field MRI, Department of Radiology;
- Netherlands Consortium for Healthy Ageing (NL)
- Leiden University Medical Center (NL)
- ORCID
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2012-02
- Volume
- 302
- Issue
- 3
- Pages
- E344-E348
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W1997137435
- Cited by
- 24
- References
- 33
- Citations by year
- 2026: 1 · 2022: 1 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- VU Research Portal (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- intramyocellular lipid, familial longevity, skeletal muscle, insulin sensitivity, insulin resistance, glucose tolerance, tibialis anterior, 1H NMR, physical activity, Leiden Longevity Study
- MeSH terms
- Aged, Family Health, Female, Humans, Insulin Resistance, Leg, Longevity, Male, Middle Aged, Motor Activity, Netherlands, Magnetic Resonance Spectroscopy, Surveys and Questionnaires, Cohort Studies, Body Mass Index, Matched-Pair Analysis, Muscle Fibers, Skeletal, Adult Children, Siblings, Lipid Metabolism
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