Psoas and paraspinous muscle index as a predictor of mortality in African American men with type 2 diabetes mellitus
Open accessAbstract
Aim Recent studies revealed a correlation between skeletal muscle mass index and density with longevity; these studies largely evaluated appendicular skeletal muscles in older Caucasians. This retrospective cohort study assessed the association between axial skeletal muscles size and density with survival in African Americans with type 2 diabetes mellitus.Methods Psoas and paraspinous muscle mass index (cross sectional area/height 2) and radiographic density (in Hounsfield Units) were measured using computed tomography in African American-Diabetes Heart Study participants, 314 women and 256 men, with median (25th, 75th quartile) age 55.0(48.0, 62.0) and 57.0(50.0, 64.0) years, respectively. Covariates in fully-adjusted model included age, sex, BMI, smoking, hormone replacement therapy (women), cardiovascular disease, hypertension, coronary artery calcified plaque mass, carotid artery calcified plaque mass, and African ancestry proportion.Results After median of 7.1(5.9, 8.2) years follow-up, 30(9.6%) of women and 49(19.1%) of men were deceased. In fully-adjusted models, psoas muscle mass index and paraspinous muscle mass index were inversely associated with mortality in men (psoas muscle mass index, hazard ratio [HR] = 0.61, P = 0.004; paraspinous muscle mass index, HR = 0.64, P = 0.004), but not in women. Psoas and paraspinous muscle densities did not associate with all-cause mortality. A penalized Cox regression that involved all covariates and predictors associated with mortality showed that only paraspinous muscle mass index remained a significant predictor of mortality (HR = 0.65, P = 0.02).Conclusion Independent from established risk factors for mortality, higher psoas and paraspinous muscle index associate with reduced all-cause mortality in middle-aged African American men with type 2 diabetes mellitus.
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Some studies have reported no association between mortality and myosteatosis.
“Not all studies, however, have found this relationship as some have reported no association between mortality and myosteatosis (Cesari et al., 2009; Murea et al., 2018).”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Murea et al., 2018
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- Authors
- Murea, M., Lenchik, L., Register, T. C., Russell, G. B., Xu, J., Smith, S. C., Bowden, D. W., Divers, J., & Freedman, B. I.
- Affiliations
- Atrium Health Wake Forest Baptist (US)
- Wake Forest University Health Sciences (US)
- Corresponding author
- Murea, Mariana
- Freedman, Barry I.
- ORCID
- Venue
- Journal of Diabetes and its Complications
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 32
- Issue
- 6
- Pages
- 558-564
- ISSN
- 0891-6632 (ISSN-L)
- 1056-8727
- PMC
- PMC5970956
- OpenAlex
- W2790780496
- Cited by
- 22
- References
- 41
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 2
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Diabetes and its Complications (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Health (R01 DK071891, HL67348)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- psoas muscle mass index, skeletal muscle density, all-cause mortality, type 2 diabetes, African American men, middle-aged adults, mortality prediction, sex differences
- MeSH terms
- Black or African American, Body Composition, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Health Status Indicators, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Tomography, X-Ray Computed, Survival Analysis, Psoas Muscles, Paraspinal Muscles
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