The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Endurance training-induced changes in insulin sensitivity and gene expression
Abstract
The beneficial effects of regular physical activity on insulin sensitivity (SI) and glucose tolerance are well documented, with considerable heterogeneity in responsiveness to exercise training (ET). To find novel candidate genes for ET-induced improvement in SI, we used microarray technology. Total RNA was isolated from vastus lateralis muscle before and after 20 wk of exercise from individuals participating in the HERITAGE Family Study. SI index was derived from a frequently sampled intravenous glucose tolerance test using MINMOD Millennium software. Sixteen subjects were selected: eight showing no changes in SI (low responders, LSIR) and eight displaying marked improvement in SI (high responders, HSIR) with ET. The SI increase was about four times greater in HSIR compared with LSIR (+3.6 +/- 0.5 vs. -1.2 +/- 0.5 microU.ml(-1).min(-1), mean +/- SE), whereas age, body mass index, percent body fat, and baseline SI were similar between the groups. Triplicate microarrays were performed, comparing pooled RNA with HSIR and LSIR individuals for differences in gene expression before and after ET using in situ-generated microarrays (18, 861 genes). Array data were validated by quantitative RT-PCR. Almost twice as many genes showed at least twofold differences between HSIR and LSIR after training compared with pretraining. We identified differentially expressed genes involved in energy metabolism and signaling, novel structural genes, and transcripts of unknown function. Genes of interest upregulated in HSIR include V-Ski oncogene, four-and-a-half LIM domain 1, and titin. Further study of these novel candidate genes should provide a better understanding of molecular mechanisms involved in the improvement in insulin sensitivity in response to regular exercise.
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“transcriptomic results from the 20-week HERITAGE cardiovascular training study indicated that certain ribosomal mRNAs in the vastus lateralis were downregulated from pre-to post-training (Teran-Garcia et al., 2005)”
From Skeletal Muscle Ribosome and Mitochondrial Biogenesis in Response to Different Exercise Training Modalities (2021) · cites this paper as Teran-Garcia et al., 2005
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Cites
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“THE BENEFICIAL EFFECTS of regular physical activity on insulin sensitivity (SI) and glucose metabolism are well documented (26, 54).”
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Mitochondrial dysfunction in the elderly: possible role in insulin resistance
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Exercise, Glucose Transport, and Insulin Sensitivity
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Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
Pillon, N. J., Gabriel, B. M., Dollet, L., Smith, J. A. B., Sardón Puig, L., Botella, J., Bishop, D. J., Krook, A., & Zierath, J. R. (2020) · Nature Communications · doi:10.1038/s41467-019-13869-w · Cited by 457
Chibalin, A. V., Leng, Y., Vieira, E., Krook, A., Björnholm, M., Long, Y. C., Kotova, O., Zhong, Z., Sakane, F., Steiler, T., et al. (2008) · Cell · doi:10.1016/j.cell.2007.12.035 · Cited by 232
Variability in training-induced skeletal muscle adaptation
Timmons, J. A. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00934.2010 · Cited by 205
Genomics and Genetics in the Biology of Adaptation to Exercise
Bouchard, C., Rankinen, T., & Timmons, J. A. (2011) · Comprehensive physiology · doi:10.1002/cphy.c100059 · Cited by 222
Self-citationGill, J. M. R., & Malkova, D. (2006) · Clinical Science · doi:10.1042/cs20050207 · Cited by 173
Metadata
- Authors
- Teran-Garcia, M., Rankinen, T., Koza, R. A., Rao, D. C., & Bouchard, C.
- Affiliations
- Pennington Biomedical Research Center (US)
- Washington University in St. Louis (US)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2005-06
- Volume
- 288
- Issue
- 6
- Pages
- E1168-E1178
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2123179027
- Cited by
- 116
- References
- 63
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 7
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 45670, R01HL045670)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK072476)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- endurance training, insulin sensitivity, gene expression, vastus lateralis, glucose tolerance, energy metabolism, titin, candidate genes, HERITAGE Family Study
- MeSH terms
- Adult, Female, Gene Expression Regulation, Glucose, Glucose Tolerance Test, Humans, Insulin, Male, Physical Endurance, RNA, Muscle, Skeletal, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Biopsy, Fine-Needle
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