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Cited by 255Adipokines, Inflammation, and Metabolic DiseasesExercise and Physiological ResponsesAdipose Tissue and Metabolism

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Exercise training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects: a 12-week randomized intervention study

Christiansen, Tore, Paulsen, Søren K., Bruun, Jens M., Pedersen, Steen B., Richelsen, Bjørn·2010·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.00574.2009
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Abstract

The purpose of this study was to investigate the effect of exercise training and diet-induced weight loss alone or in combination on inflammatory markers in circulation, in adipose tissue (AT) and in skeletal muscle (SM) in obese subjects. Seventy-nine obese subjects were randomized into a 12-wk intervention: 1) exercise only (EXO), 2) diet-induced weight loss using a very low energy diet (DIO), and 3) exercise and diet-induced weight-loss combined (DEX). Blood samples (metabolic and inflammatory markers) and AT and SM biopsies (mRNA expression) were collected at baseline and after 12 wk. In the EXO group the weight loss was 3.5 kg and in the DIO and DEX groups it was 12 kg in both. Vo(2max) was increased by 14-18% in the EXO and DEX groups with no changes in the DIO group. In the DIO and DEX groups, circulating levels of MCP-1, MIP-1alpha, IL-15, and IL-18 were decreased, and adiponectin was increased (P < 0.05 for all). In the EXO group, MCP-1 was decreased with 10% (P = 0.06). By combining the weight loss in all three groups, we found a correlation between the degree of weight loss and improvement in several of the inflammatory markers (P < 0.05). In AT biopsies, subjects in the DIO and DEX groups achieved a general beneficial but nonsignificant effect on the gene expression of inflammatory markers. In the EXO group, no changes in AT adipokine mRNA were found except for an increment of adiponectin (P < 0.05). In SM, the only observed change was that the gene expression of IL-6 was increased in all three groups (P < 0.05). In conclusion, rather large weight losses (>5-7%) were found to have beneficial effects on circulating inflammatory markers in these obese subjects. Aerobic exercise for 12 wk, which increased Vo(2max), was found to have no effects on circulating inflammatory markers in these obese patients. It is suggested that more intensive exercise may be necessary to affect systemic inflammation.

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Crossref · 10.1152/ajpendo.00574.2009

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  1. Barra NG, 2009, Obesity (Silver Spring)

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Metadata

Authors
Christiansen, T., Paulsen, S. K., Bruun, J. M., Pedersen, S. B., & Richelsen, B.
Affiliations
Aarhus University Hospital (DK)
Corresponding author
Christiansen, Tore
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
2010-04
Volume
298
Issue
4
Pages
E824-E831
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.00574.2009
OpenAlex
W2111106822
Cited by
255
References
55
Citations by year
2026: 5 · 2025: 5 · 2024: 12 · 2023: 13 · 2022: 14 · 2021: 19 · 2020: 15 · 2019: 11 · 2018: 18 · 2017: 18 · 2016: 19 · 2015: 22 · 2014: 21 · 2013: 25 · 2012: 18
FWCI
14.65
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords
obesity, exercise training, diet-induced weight loss, very low calorie diet, inflammatory markers, adipose tissue inflammation, skeletal muscle inflammation, adiponectin, MCP-1, MIP-1α, IL-15, IL-18, interleukin-6, aerobic exercise, VO2max, metabolic risk factors
MeSH terms
Adipose Tissue, Adolescent, Adult, Blood Glucose, Blood Pressure, Blood Proteins, Body Weight, Diet, Reducing, Female, Humans, Inflammation, Insulin, Lipids, Male, Middle Aged, Obesity, Physical Education and Training, Risk Factors, Anaerobic Threshold, Biomarkers, Weight Loss, Exercise, Gene Expression, Muscle, Skeletal, Young Adult

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