The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Exercise training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects: a 12-week randomized intervention study
Abstract
The purpose of this study was to investigate the effect of exercise training and diet-induced weight loss alone or in combination on inflammatory markers in circulation, in adipose tissue (AT) and in skeletal muscle (SM) in obese subjects. Seventy-nine obese subjects were randomized into a 12-wk intervention: 1) exercise only (EXO), 2) diet-induced weight loss using a very low energy diet (DIO), and 3) exercise and diet-induced weight-loss combined (DEX). Blood samples (metabolic and inflammatory markers) and AT and SM biopsies (mRNA expression) were collected at baseline and after 12 wk. In the EXO group the weight loss was 3.5 kg and in the DIO and DEX groups it was 12 kg in both. Vo(2max) was increased by 14-18% in the EXO and DEX groups with no changes in the DIO group. In the DIO and DEX groups, circulating levels of MCP-1, MIP-1alpha, IL-15, and IL-18 were decreased, and adiponectin was increased (P < 0.05 for all). In the EXO group, MCP-1 was decreased with 10% (P = 0.06). By combining the weight loss in all three groups, we found a correlation between the degree of weight loss and improvement in several of the inflammatory markers (P < 0.05). In AT biopsies, subjects in the DIO and DEX groups achieved a general beneficial but nonsignificant effect on the gene expression of inflammatory markers. In the EXO group, no changes in AT adipokine mRNA were found except for an increment of adiponectin (P < 0.05). In SM, the only observed change was that the gene expression of IL-6 was increased in all three groups (P < 0.05). In conclusion, rather large weight losses (>5-7%) were found to have beneficial effects on circulating inflammatory markers in these obese subjects. Aerobic exercise for 12 wk, which increased Vo(2max), was found to have no effects on circulating inflammatory markers in these obese patients. It is suggested that more intensive exercise may be necessary to affect systemic inflammation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Therefore, in humans, when IL-10 is added to the culture medium of mononuclear cells and circulating neutrophils stimulated with lipopolysaccharide(LPS), the synthesis of proinflammatory cytokines (TNF-α, IL-1β, IL-6) is inhibited through post-transcriptional mechanisms, a direct consequence of a higher mRNA degradation rate of the corresponding genes (Christiansen et al., 2010).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Christiansen et al., 2010
Citations
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
The anti-inflammatory effect of exercise
Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100 · cited 2×
“Skeletal muscle (SM) expresses IL-6, IL-8, and IL-15 (41) and as the increase in plasma IL-6 during strenuous exercise is followed by increased levels of the anti-inflammatory protein IL-10, it is suggested that the muscle-derived IL-6 could be involved in mediating an antiinflammatory environment (42).”
BackgroundMuscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Inflammation: the link between insulin resistance, obesity and diabetes
Dandona, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2003.10.013 · Cited by 2,170
XENical in the Prevention of Diabetes in Obese Subjects (XENDOS) Study
Torgerson, J. S., Hauptman, J., Boldrin, M. N., & Sjöström, L. (2004) · Diabetes Care · doi:10.2337/diacare.27.1.155 · Cited by 1,915
Lindström, J., Ilanne-Parikka, P., Peltonen, M., Aunola, S., Eriksson, J. G., Hemiö, K., Hämäläinen, H., Härkönen, P., Keinänen-Kiukaanniemi, S., Laakso, M., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69701-8 · Cited by 1,799
Fain, J. N., Madan, A. K., Hiler, M. L., Cheema, P. S., & Bahouth, S. W. (2004) · Endocrinology · doi:10.1210/en.2003-1336 · Cited by 1,619
Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
Hotamışlıgil, G. S., Murray, D. L., Choy, L., & Spiegelman, B. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4854 · Cited by 1,220
Cancello, R., Henegar, C., Viguerie, N., Taleb, S., Poitou, C., Rouault, C., Coupaye, M., Pelloux, V., Hugol, D., Bouillot, J.-L., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2277 · Cited by 1,164
Advances in Male Contraception
Page, S. T., Amory, J. K., & Bremner, W. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0041 · Cited by 1,138
The Perfect Storm: Obesity, Adipocyte Dysfunction, and Metabolic Consequences
de Ferranti, S. D., & Mozaffarian, D. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.100156 · Cited by 755
Weight loss regulates inflammation‐related genes in white adipose tissue of obese subjects
ClÉment, K., Viguerie, N., Poitou, C., Carette, C., Pelloux, V., Curat, C. A., Sicard, A., Rome, S., Benis, A., Zucker, J., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2204com · Cited by 640
Adipose Tissue-Derived Factors: Impact on Health and Disease
Trujillo, M. E., & Scherer, P. E. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0033 · Cited by 624
Gielen, S., Adams, V., Möbius-Winkler, S., Linke, A., Erbs, S., Yu, J., Kempf, W., Schubert, A., Schuler, G., & Hambrecht, R. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00848-9 · Cited by 613 · cited 1×
“Subjects in the present study were obese but, as mentioned, metabolically rather healthy, whereas in studies showing an exercise-induced anti-inflammatory effect in SM the subjects had more metabolic diseases like type 2 diabetes (45), were frail or elderly, or had chronic heart failure (21, 34).”
MethodAbramson, J. L., & Vaccarino, V. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.11.1286 · Cited by 513
Inflammation and Atherosclerosis
Stoll, G., & Bendszus, M. (2006) · Stroke · doi:10.1161/01.str.0000226901.34927.10 · Cited by 506
Resistance exercise decreases skeletal muscle tumor necrosis factor α in frail elderly humans
GREIWE, J. S., CHENG, B., RUBIN, D. C., YARASHESKI, K. E., & SEMENKOVICH, C. F. (2001) · The FASEB Journal · doi:10.1096/fj.00-0274com · Cited by 454
Nicklas, B. J., Ambrosius, W., Messier, S. P., Miller, G. D., Penninx, B. W., Loeser, R. F., Palla, S., Bleecker, E., & Pahor, M. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.4.544 · Cited by 443
Bruun, J. M., Helge, J. W., Richelsen, B., & Stallknecht, B. M. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00506.2005 · Cited by 437
Christiansen, T., Richelsen, B., & Bruun, J. M. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802839 · Cited by 424
Targeting the Metabolic Syndrome with Exercise: Evidence from the HERITAGE Family Study
Katzmarzyk, P. T., Leon, A. S., Wilmore, J. H., Skinner, J. S., Rao, D. C., Rankinen, T., & Bouchard, C. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000089337.73244.9b · Cited by 396
Obesity and inflammation: the effects of weight loss
Forsythe, L. K., Wallace, J. M. W., & Livingstone, M. B. E. (2008) · Nutrition Research Reviews · doi:10.1017/s0954422408138732 · Cited by 381 · cited 1×
“Degree of weight loss has previously been shown to be of importance for the improvement in circulating inflammatory markers (20), and in accord with this we found that subjects achieving weight losses above 14% (highest tertile of weight reduction) had a more pronounced decrement in circulating proinflammatory adipoki…”
ResultPhysical training reduces peripheral markers of inflammation in patients with chronic heart failure
Adamopoulos, S. N. (2001) · European Heart Journal · doi:10.1053/euhj.2000.2285 · Cited by 373
Huber, J., Kiefer, F. W., Zeyda, M., Ludvik, B. H., Silberhumer, G. R., Prager, G., Zlabinger, G. J., & Stulnig, T. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2630 · Cited by 365
Exercise training modulates cytokines activity in coronary heart disease patients
Goldhammer, E., Tanchilevitch, A., Maor, I., Beniamini, Y., Rosenschein, U., & Sagiv, M. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.08.073 · Cited by 363
The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus
Kadoglou, N. P. E., Iliadis, F., Angelopoulou, N., Perrea, D., Ampatzidis, G., Liapis, C. D., & Alevizos, M. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3282efaf50 · Cited by 337
Blüher, M., Bullen, J. W., Lee, J. H., Kralisch, S., Fasshauer, M., Klöting, N., Niebauer, J., Schön, M. R., Williams, C. J., & Mantzoros, C. S. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2556 · Cited by 293
The role of physical activity in producing and maintaining weight loss
Catenacci, V. A., & Wyatt, H. R. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0554 · Cited by 279
Oversecretion of interleukin-15 from skeletal muscle reduces adiposity
Quinn, L. S., Anderson, B. G., Strait-Bodey, L., Stroud, A. M., & Argilés, J. M. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90506.2008 · Cited by 267 · cited 1×
“IL-15 has been found to be highly expressed in muscle tissue, and it is suggested to have regulatory effects on the amount of body fat, maybe particularly through a reduction of the trunk fat mass that has been found at least in mice overexpressing IL-15 in skeletal muscle (44).”
BackgroundLambert, C. P., Wright, N. R., Finck, B. N., & Villareal, D. T. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00006.2008 · Cited by 249
Varma, V., Yao-Borengasser, A., Rasouli, N., Nolen, G. T., Phanavanh, B., Starks, T., Gurley, C., Simpson, P., McGehee, R. E., Kern, P. A., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90885.2008 · Cited by 229
Polak, J., Klimčáková, E., Moro, C., Viguerie, N., Berlan, M., Hejnová, J., Richterova, B., Kraus, I., Langin, D., & Štich, V. (2006) · Metabolism · doi:10.1016/j.metabol.2006.06.008 · Cited by 224
Effect of Exercise on Circulating Adipokine Levels in Obese Young Women
KONDO, T., Kobayashi, I., & Murakami, M. (2006) · Endocrine Journal · doi:10.1507/endocrj.53.189 · Cited by 217
Madsen, E. L., Rissanen, A., Bruun, J. M., Skogstrand, K., Tonstad, S., Hougaard, D. M., & Richelsen, B. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0721 · Cited by 201
Oberbach, A., Tönjes, A., Klöting, N., Faßhauer, M., Kratzsch, J., Busse, M. W., Paschke, R., Stümvoll, M., & Blüher, M. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02127 · Cited by 199
Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass
Nielsen, A. R., Højman, P., Erikstrup, C., Fischer, C. P., Plomgaard, P., Mounier, R., Mortensen, O. H., Broholm, C., Taudorf, S., Krogh‐Madsen, R., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2561 · Cited by 194
Kopp, H., Krzyżanowska, K., Möhlig, M., Spranger, J., Pfeiffer, A. F. H., & Schernthaner, G.-H. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802983 · Cited by 190
Trøseid, M. (2004) · European Heart Journal · doi:10.1016/j.ehj.2003.12.006 · Cited by 188
Local Expression of Inflammatory Cytokines in Human Atherosclerotic Plaques
Wilcox, J. N., Nelken, N. A., Coughlin, S. R., Gordon, D., & Schall, T. J. (1994) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat1994.1.supplemment1_s10 · Cited by 177
Dekker, M. J., Lee, S., HUDSON, R. W., Kilpatrick, K., Graham, T. E., Ross, R., & Robinson, L. E. (2007) · Metabolism · doi:10.1016/j.metabol.2006.10.015 · Cited by 176
Carbó, N., López-Soriano, J., Costelli, P., Alvarez, B., Busquets, S., Baccino, F. M., Quinn, L. S., López-Soriano, F. J., & Argilés, J. M. (2001) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(00)00188-4 · Cited by 174 · cited 1×
“IL-15 is suggested to act as an antiadipogenic cytokine, since cell culture studies have shown that IL-15 inhibits preadipocyte differentiation, and administration of IL-15 to rodents is shown to be associated with a decrease in fat mass (9).”
BackgroundKlimčáková, E., Polak, J., Moro, C., Hejnová, J., Majercik, M., Viguerie, N., Berlan, M., Langin, D., & Štich, V. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0382 · Cited by 163
Sriwijitkamol, A., Christ-Roberts, C. Y., Berria, R., Eagan, P. A., Pratipanawatr, T., DeFronzo, R. A., Mandarino, L. J., & Musi, N. (2006) · Diabetes · doi:10.2337/diabetes.55.03.06.db05-0677 · Cited by 146
Interleukin-15 contributes to the regulation of murine adipose tissue and human adipocytes
Barra, N. G., Reid, S., MacKenzie, R., Werstuck, G., Trigatti, B. L., Richards, C., Holloway, A. C., & Ashkar, A. A. (2010) · Obesity · doi:10.1038/oby.2009.445 · Cited by 116
Strączkowski, M., Kowalska, I., Dzienis-Straczkowska, S., Stępień, A., Skibinska, E., Szelachowska, M., & Kinalska, I. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1450273 · Cited by 101
Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells
Bilan, P. J., Samokhvalov, V., Koshkina, A., Schertzer, J. D., Samaan, M. C., & Klip, A. (2009) · Archives of Physiology and Biochemistry · doi:10.1080/13813450903079314 · Cited by 88
Christiansen, T., Paulsen, S. K., Bruun, J. M., Overgaard, K., Ringgaard, S., Pedersen, S. B., Positano, V., & Richelsen, B. (2009) · European Journal of Endocrinology · doi:10.1530/eje-08-1009 · Cited by 74
Carroll, H. P., Paunović, V., & Gadina, M. (2008) · Lara D. Veeken · doi:10.1093/rheumatology/ken257 · Cited by 71
de Jager, S. C. A., Kraaijeveld, A. O., Grauss, R. W., de Jager, W., Liem, S., van der Hoeven, B. L., Prakken, B. J., Putter, H., van Berkel, T. J. C., Atsma, D. E., et al. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.06.003 · Cited by 70
Interleukin-15 Expression in Atherosclerotic Plaques
Houtkamp, M., van der Wal, A. C., de Boer, O. J., van der Loos, C. M., de Boer, P. A. J., Moorman, A. F. M., & Becker, A. E. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0701.092162 · Cited by 61
Serum Interleukin-15 Concentration in Patients With Essential Hypertension
Kaibe, M., Ohishi, M., Ito, N., Ma, Y., TAKAGI, T., TERAI, M., Tatara, Y., Komai, N., Rakugi, H., & Ogihara, T. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.02.014 · Cited by 36
Research works printed but not linked: 1
- Barra NG, 2009, Obesity (Silver Spring)
Cited by
Sorted by citations
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
Pedersen, B. K. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120033 · Cited by 516
Physical Activity and Exercise in the Regulation of Human Adipose Tissue Physiology
Thompson, D., Karpe, F., Lafontan, M., & Frayn, K. N. (2012) · Physiological Reviews · doi:10.1152/physrev.00012.2011 · Cited by 425
“In a separate report from this investigation (39), there was no change in abdominal SCAT gene expression (mRNA) for various adipokines (IL-6, MCP-1, MIP-1 , TNF- , leptin) and no change in markers of macrophage accumulation (CD68 and CD14) with regular exercise training (samples collected 24–48 h after the last bout o…”
BackgroundLeal, L. G., Lopes, M. A., & Batista, M. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01307 · Cited by 382
“Therefore, in humans, when IL-10 is added to the culture medium of mononuclear cells and circulating neutrophils stimulated with lipopolysaccharide(LPS), the synthesis of proinflammatory cytokines (TNF-α, IL-1β, IL-6) is inhibited through post-transcriptional mechanisms, a direct consequence of a higher mRNA degradati…”
BackgroundThe effect of physical activity on mediators of inflammation
Nimmo, M. A., Leggate, M., Viana, J. L., & King, J. A. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12156 · Cited by 311
Metadata
- Authors
- Christiansen, T., Paulsen, S. K., Bruun, J. M., Pedersen, S. B., & Richelsen, B.
- Affiliations
- Aarhus University Hospital (DK)
- Corresponding author
- Christiansen, Tore
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2010-04
- Volume
- 298
- Issue
- 4
- Pages
- E824-E831
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2111106822
- Cited by
- 255
- References
- 55
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 12 · 2023: 13 · 2022: 14 · 2021: 19 · 2020: 15 · 2019: 11 · 2018: 18 · 2017: 18 · 2016: 19 · 2015: 22 · 2014: 21 · 2013: 25 · 2012: 18
- FWCI
- 14.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- obesity, exercise training, diet-induced weight loss, very low calorie diet, inflammatory markers, adipose tissue inflammation, skeletal muscle inflammation, adiponectin, MCP-1, MIP-1α, IL-15, IL-18, interleukin-6, aerobic exercise, VO2max, metabolic risk factors
- MeSH terms
- Adipose Tissue, Adolescent, Adult, Blood Glucose, Blood Pressure, Blood Proteins, Body Weight, Diet, Reducing, Female, Humans, Inflammation, Insulin, Lipids, Male, Middle Aged, Obesity, Physical Education and Training, Risk Factors, Anaerobic Threshold, Biomarkers, Weight Loss, Exercise, Gene Expression, Muscle, Skeletal, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
