The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: evidence of a mitochondrial lactate oxidation complex
Abstract
Results of previous studies suggested a role of mitochondria in intracellular and cell-cell lactate shuttles. Therefore, by using a rat-derived L6 skeletal muscle cell line and confocal laser-scanning microscopy (CLSM), we examined the cellular locations of mitochondria, lactate dehydrogenase (LDH), the lactate-pyruvate transporter MCT1, and CD147, a purported chaperone protein for MCT1. CLSM showed that LDH, MCT1, and CD147 are colocalized with the mitochondrial reticulum. Western blots showed that cytochrome oxidase (COX), NADH dehydrogenase, LDH, MCT1, and CD147 are abundant in mitochondrial fractions of L6 cells. Interactions among COX, MCT1, and CD147 in mitochondria were confirmed by immunoblotting after immunoprecipitation. These findings support the presence of a mitochondrial lactate oxidation complex associated with the COX end of the electron transport chain that might explain the oxidative catabolism of lactate and, hence, mechanism of the intracellular lactate shuttle.
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Cites
Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1
Brooks, G. A., Brown, M. A., Butz, C. E., Sicurello, J. P., & Dubouchaud, H. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.5.1713 · Cited by 185
Self-citationMitochondrial reticulum in limb skeletal muscle
Kirkwood, S. P., Munn, E. A., & Brooks, G. A. (1986) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1986.251.3.c395 · Cited by 179
Self-citationMitochondrial tissue specificity of substrates utilization in rat cardiac and skeletal muscles
Ponsot, E., Zoll, J., N'Guessan, B., Ribera, F., Lampert, E., Richard, R., Veksler, V., Ventura‐Clapier, R., & Mettauer, B. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20245 · Cited by 83
Cited by
Cancer cell metabolism: warburg and beyond
Hsu, P. P., & Sabatini, D. M. (2008) · Cell · doi:10.1016/j.cell.2008.08.021 · Cited by 2,452
“Transported by several monocarboxylate transporters, lactate may be shared and metabolized among cells, although the idea is still controversial (Hashimoto et al., 2006; Yoshida et al., 2007).”
BackgroundTargeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
Sonveaux, P., Végran, F., Schroeder, T., Wergin, M. C., Verrax, J., Rabbani, Z. N., De Saedeleer, C. J., Kennedy, K. M., Diepart, C., Jordan, B. F., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36843 · Cited by 1,624
The Science and Translation of Lactate Shuttle Theory
Brooks, G. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.008 · Cited by 1,486
Self-citationLactate metabolism in human health and disease
Li, X., Yang, Y., Zhang, B., Lin, X., Fu, X., An, Y., Zou, Y., Wang, J.-X., Wang, Z., & Yu, T. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01151-3 · Cited by 1,454
Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
de la Cruz-López, K. G., Castro-Muñoz, L. J., Reyes-Hernández, D. O., García-Carrancá, A., & Manzo-Merino, J. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01143 · Cited by 940
Metadata
- Authors
- Hashimoto, T., Hussien, R., & Brooks, G. A.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2006-06
- Volume
- 290
- Issue
- 6
- Pages
- E1237-E1244
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2125035313
- Cited by
- 250
- References
- 3
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hashimoto, T., Hussien, R., & Brooks, G. A. (2006). Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: evidence of a mitochondrial lactate oxidation complex. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00594.2005
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