Defective prolactin signaling impairs pancreatic β-cell development during the perinatal period
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Prolactin (PRL) and placental lactogens stimulate β-cell replication and insulin production in pancreatic islets and insulinoma cells through binding to the PRL receptor (PRLR). However, the contribution of PRLR signaling to β-cell ontogeny and function in perinatal life and the effects of the lactogens on adaptive islet growth are poorly understood. We provide evidence that expansion of β-cell mass during both embryogenesis and the postnatal period is impaired in the PRLR−/−mouse model. PRLR−/−newborns display a 30% reduction of β-cell mass, consistent with reduced proliferation index at E18.5. PRL stimulates leucine incorporation and S6 kinase phosphorylation in INS-1 cells, supporting a role for β-cell mTOR signaling in PRL action. Interestingly, a defect in the development of acini is also observed in absence of PRLR signaling, with a sharp decline in cellular size in both endocrine and exocrine compartments. Of note, a decrease in levels of IGF-II, a PRL target, in the Goto-Kakizaki (GK) rat, a spontaneous model of type 2 diabetes, is associated with a lack of PRL-mediated β-cell proliferation in embryonic pancreatic buds. Reduced pancreatic IGF-II expression in both rat and mouse models suggests that this factor may constitute a molecular link between PRL signaling and cell ontogenesis. Together, these results provide evidence that PRL signaling is essential for pancreas ontogenesis during the critical perinatal window responsible for establishing functional β-cell reserve.
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Prolactin is essential for adequate β-cell proliferation, as demonstrated in mouse knockouts of the prolactin receptor.
“Prolactin is also essential for adequate β-cell proliferation, as demonstrated in mouse knockouts of the prolactin receptor (PrlR−/−) [80].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [80]
Cites
Bôle-Feysot, C., Goffin, V., Edery, M., Binart, N., & Kelly, P. (1998) · Endocrine reviews · doi:10.1210/edrv.19.3.0334 · Cited by 1,973 · see citing works
Self-citationPancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
Talchai, C., Xuan, S., Lin, H. V., Sussel, L., & Accili, D. (2012) · Cell · doi:10.1016/j.cell.2012.07.029 · Cited by 1,415 · see citing works
Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.
Böhni, R., Riesgo-Escovar, J., Oldham, S., Brogiolo, W., Stocker, H., Andruss, B., Beckingham, K., & Hafen, E. (1999) · Cell · doi:10.1016/s0092-8674(00)80799-0 · Cited by 863 · see citing works
Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse.Preprint
Ormandy, C. J., Camus, A., Barra, J., Damotte, D., Lucas, B., Buteau, H., Edery, M., Brousse, N., Babinet, C., Binart, N., et al. (1997) · Genes & Development · doi:10.1101/gad.11.2.167 · Cited by 806 · see citing works
Self-citationMeier, J. J., Butler, A. E., Saisho, Y., Monchamp, T., Galasso, R., Bhushan, A., Rizza, R. A., & Butler, P. C. (2008) · Diabetes · doi:10.2337/db07-1369 · Cited by 683 · see citing works
Serotonin regulates pancreatic beta cell mass during pregnancy
Kim, H., Toyofuku, Y., Lynn, F. C., Chak, E., Uchida, T., Mizukami, H., Fujitani, Y., Kawamori, R., Miyatsuka, T., Kosaka, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2173 · Cited by 586 · see citing works
What Can We Learn from Rodents about Prolactin in Humans?
Ben‐Jonathan, N., LaPensee, C. R., & LaPensee, E. W. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0017 · Cited by 527 · see citing works
Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα
Tuttle, R. L., Gill, N. S., Pugh, W., Lee, J.-P., Koeberlein, B., Furth, E. E., Polonsky, K. S., Naji, A., & Birnbaum, M. J. (2001) · Nature Medicine · doi:10.1038/nm1001-1133 · Cited by 511 · see citing works
Placental hormones and the control of maternal metabolism and fetal growth
Newbern, D., & Freemark, M. (2011) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e32834c800d · Cited by 487 · see citing works
Self-citationHypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
Pende, M., Kozma, S. C., Jaquet, M., Oorschot, V. M. J., Burcelin, R., MARCHAND‐BRUSTEL, Y. L., Klumperman, J., Thorens, B., & Thomas, G. W. (2000) · Nature · doi:10.1038/35050135 · Cited by 452 · see citing works
Prolactin: The New Biology of an Old Hormone
Goffin, V., Binart, N., Touraine, P. A., & Kelly, P. A. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.131049 · Cited by 416 · see citing works
Self-citationBrelje, T. C., Scharp, D. W., Lacy, P. E., Ogren, L., Talamantes, F. J., Robertson, M. C., Friesen, H. G., & Sorenson, R. L. (1993) · Endocrinology · doi:10.1210/endo.132.2.8425500 · Cited by 409 · see citing works
Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
Verdú, J., Buratovich, M., Wilder, E., & Birnbaum, M. (1999) · Nature Cell Biology · doi:10.1038/70293 · Cited by 397 · see citing works
Production of Spontaneous Diabetic Rats by Repetition of Selective Breeding
Gotō, Y., KAKIZAKI, M., & MASAKI, N. (1976) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.119.85 · Cited by 389 · see citing works
Karnik, S. K., Chen, H., McLean, G. W., Heit, J. J., Gu, X., Zhang, A. Y., Fontaine, M., Yen, M. H., & Kim, S. K. (2007) · Science · doi:10.1126/science.1146812 · Cited by 353 · see citing works
Miralles, F., Czernichow, P., & Scharfmann, R. (1998) · Development · doi:10.1242/dev.125.6.1017 · Cited by 276 · see citing works
Huang, C., Snider, F., & Cross, J. C. (2009) · Endocrinology · doi:10.1210/en.2008-1003 · Cited by 275 · see citing works
Freemark, M. (2002) · Endocrinology · doi:10.1210/en.143.4.1378 · Cited by 258 · see citing works
Self-citationVasavada, R. C., Garcia-Ocaña, A., Zawalich, W. S., Sorenson, R. L., Dann, P., Syed, M., Ogren, L., Talamantes, F., & Stewart, A. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.15399 · Cited by 212 · see citing works
Pdx1 restores β cell function in Irs2 knockout mice
Kushner, J. A., Ye, J., Schubert, M., Burks, D. J., Dow, M. A., Flint, C. L., Dutta, S., Wright, C. V. E., Montminy, M., & White, M. F. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14439 · Cited by 186 · see citing works
IGF-2 Is a Mediator of Prolactin-Induced Morphogenesis in the Breast
Brisken, C., Ayyanan, A., Nguyen, B.-C., Heineman, A., Reinhardt, F., Jan, T., Dey, S. K., Dotto, G. P., & Weinberg, R. A. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00365-9 · Cited by 175 · see citing works
Growth hormone regulates the abundance of insulin-like growth factor I RNA in adult rat liver.
Roberts, C. T., Brown, A. L., Graham, D. E., et al. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67484-8 · Cited by 174 · see citing works
Zhang, H., Zhang, J., Pope, C. F., Crawford, L. A., Vasavada, R. C., Jagasia, S. M., & GANNON, M. A. (2009) · Diabetes · doi:10.2337/db09-0050 · Cited by 172 · see citing works
Molecular Mechanisms of Prolactin and Its Receptor
Brooks, C. L. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1040 · Cited by 169 · see citing works
Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy
Schraenen, A., Lemaire, K., de Faudeur, G., Hendrickx, N., Granvik, M., Lommel, L. V., Mallet, J. J., Vodjdani, G., Gilon, P., Binart, N., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1913-7 · Cited by 142 · see citing works
Self-citationSpecifying pancreatic endocrine cell fates.
Collombat, P., Hecksher-Sørensen, J., Serup, P., & Mansouri, A. (2006) · Mechanisms of Development · doi:10.1016/j.mod.2006.05.006 · Cited by 142 · see citing works
Neurogenin3: A master regulator of pancreatic islet differentiation and regeneration
Rukstalis, J. M., & Habener, J. F. (2009) · Islets · doi:10.4161/isl.1.3.9877 · Cited by 131 · see citing works
Impact of prolactin receptor isoforms on reproduction
Binart, N., Bachelot, A., & Bouilly, J. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.01.008 · Cited by 119 · see citing works
Self-citationCritical roles for the TSC-mTOR pathway in β-cell function
Mori, H., Inoki, K., Opland, D. M., Münzberg, H., Villanueva, E. C., Faouzi, M., Ikenoue, T., Kwiatkowski, D. J., MacDougald, O. A., Myers, M. G., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00262.2009 · Cited by 103 · see citing works
Freemark, M., Driscoll, P., Maaskant, R. A., Petryk, A., & Kelly, P. A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119239 · Cited by 103 · see citing works
Self-citationLactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation
Fujinaka, Y., Takane, K., Yamashita, H., & Vasavada, R. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702607200 · Cited by 92 · see citing works
Placental Hormones and the Control of Fetal Growth
Freemark, M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0517 · Cited by 87 · see citing works
Self-citationGraham, D. E., Rechler, M. M., Brown, A. L., et al. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4519 · Cited by 78 · see citing works
Caldérari, S., Gangnerau, M.-N., Thibault, M., Meile, M.-J., Kassis, N., Álvarez, C., Portha, B., & Serradas, P. (2007) · Diabetologia · doi:10.1007/s00125-007-0676-2 · Cited by 75 · see citing works
Viengchareun, S., Servel, N., Fève, B., Freemark, M., Lombès, M., & Binart, N. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001535 · Cited by 74 · see citing works
Self-citationProlactin signaling mechanisms in ovary
Bouilly, J., Sonigo, C., Auffret, J., Gibori, G., & Binart, N. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.05.004 · Cited by 70 · see citing works
Self-citationFreemark, M., Kirk, K., Pihoker, C., et al. (1993) · Endocrinology · doi:10.1210/en.133.4.1830 · Cited by 65 · see citing works
Self-citationArumugam, R., Horowitz, E., Lu, D., Collier, J. J., Ronnebaum, S. M., Fleenor, D., & Freemark, M. (2008) · Endocrinology · doi:10.1210/en.2008-0051 · Cited by 61 · see citing works
Self-citationEffect of forkhead box O1 (FOXO1) on beta cell development in the human fetal pancreas
Al‐Masri, M., Krishnamurthy, M., Li, J., Fellows, G. F., Dong, H. H., Goodyer, C. G., & Wang, R. (2009) · Diabetologia · doi:10.1007/s00125-009-1632-0 · Cited by 56 · see citing works
Mechanisms of KGF Mediated Signaling in Pancreatic Duct Cell Proliferation and Differentiation
Uzan, B., Figeac, F., Portha, B., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004734 · Cited by 52 · see citing works
Self-citationLui, J. C. K., & Baron, J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219079110 · Cited by 51 · see citing works
Movassat, J., Bailbé, D., Lubrano-Berthelier, C., Picarel-Blanchot, F., Bertin, É., Mourot, J., & Portha, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00501.2007 · Cited by 51 · see citing works
Self-citationFang, L., Wang, L. Y., Wang, N., Li, L., Li, L. J., Zheng, Y., Lou, H., Liu, X. Z., Xu, X. R., Sheng, J. Z., et al. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.112.106070 · Cited by 44 · see citing works
Fleenor, D., Petryk, A., Driscoll, P., & Freemark, M. (2000) · Pediatric Research · doi:10.1203/00006450-200001000-00023 · Cited by 44 · see citing works
Self-citationKondegowda, N. G., Mozar, A., Chin, C., Otero, P. A., Garcı́a-Ocaña, A., & Vasavada, R. C. (2012) · Diabetologia · doi:10.1007/s00125-012-2501-9 · Cited by 35 · see citing works
Arumugam, R., Fleenor, D. E., Lu, D., & Freemark, M. (2011) · Endocrinology · doi:10.1210/en.2010-1258 · Cited by 28 · see citing works
Self-citationEnhanced cell proliferation by hyperprolactinemia in both exocrine and endocrine pancreas in mice
Matsuda, M., Mori, T., Park, M. K., et al. (1994) · European Journal of Endocrinology · doi:10.1530/eje.0.1300187 · Cited by 19 · see citing works
Flagged first, then by citations
1 of the 48 references couldn’t be matched to a known paper.
Cited by
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The Pathophysiology of Gestational Diabetes Mellitus
Plows, J. F., Stanley, J. L., Baker, P. N., Reynolds, C. M., & Vickers, M. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113342 · Cited by 1,874 · see citing works
“Prolactin is also essential for adequate β-cell proliferation, as demonstrated in mouse knockouts of the prolactin receptor (PrlR−/−) [80].”
BackgroundOn being the right (cell) size
Ginzberg, M., Kafri, R., & Kirschner, M. (2015) · Science · doi:10.1126/science.1245075 · Cited by 390 · see citing works
Prolactin — a pleiotropic factor in health and disease
Bernard, V., Young, J., & Binart, N. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0194-6 · Cited by 283 · see citing works
Self-citationNew insights in prolactin: pathological implications
Bernard, V., Young, J., Chanson, P., & Binart, N. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.36 · Cited by 244 · see citing works
Self-citationNatural history of β-cell adaptation and failure in type 2 diabetes
Alejandro, E. U., Gregg, B. E., Blandino-Rosano, M., CRAS-MÉNEUR, C. M. H., & Bernal‐Mizrachi, E. (2014) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.002 · Cited by 235 · see citing works
Time for a New Perspective on Prolactin in Metabolism
Macotela, Y., Triebel, J., & Clapp, C. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.01.004 · Cited by 133 · see citing works
Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells
Banerjee, R. R., Cyphert, H. A., Walker, E. M., Chakravarthy, H., Peiris, H., Gu, X., Liu, Y., Conrad, E., Goodrich, L., Stein, R. W., et al. (2016) · Diabetes · doi:10.2337/db15-1527 · Cited by 131 · see citing works
“Additional studies have indicated a role for PRLR signaling in fetal and early postnatal islet development (35).”
BackgroundPostolache, T. T., del Bosque‐Plata, L., Jabbour, S. A., Vergare, M. J., Wu, R., & Gragnoli, C. (2019) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32712 · Cited by 107 · see citing works
“NPY is implicated in the SCZ-T2D pathway and/or comorbidity (Lin & Shuldiner, 2010; Liu et al., 2013).”
BackgroundInfluentialDeep Insight of the Pathophysiology of Gestational Diabetes Mellitus
Sharma, A. K., Singh, S., Singh, H., Mahajan, D., Kolli, P., Mandadapu, G., Kumar, B., Kumar, D., Kumar, S., & Jena, M. K. (2022) · Cells · doi:10.3390/cells11172672 · Cited by 114 · see citing works
“The β-cell proliferation is also supported by the infusion of prolactin, as observed in a mouse knock-out model of the prolactin receptor [61].”
BackgroundHuang, C. L., Walker, E. M., Dadi, P. K., Hu, R., Xu, Y., Zhang, W., Sanavia, T., Mun, J., Liu, J., Nair, G. G., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.03.013 · Cited by 97 · see citing works
“Interestingly, prolactin receptor-mediated signaling, required for perinatal β-cell development (Auffret et al., 2013), positively regulates Syt4 expression (Cunha et al.”
BackgroundMetabolic functions of prolactin: Physiological and pathological aspects
Lopez‐Vicchi, F., Winne, C. D., Brie, B., Sorianello, E. M., Ladyman, S. R., & Becú‐Villalobos, D. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12888 · Cited by 95 · see citing works
Marrif, H. I., & Alsunousi, S. I. A. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00083 · Cited by 69 · see citing works
“…and function Hui and Perfetti, 2002 Growth hormone (GH) β cell proliferation Nielsen et al., 1989 Prolactin (PRL) β cell differentiation and morphogenesis Auffret et al., 2013 Placental lactogen (PL) β cell proliferation and phenotype Fleenor et al., 2000 Parathyroid hormone-related protein…”
BackgroundGlintborg, D., Altinok, M., Mumm, H., Buch, K., Ravn, P., & Andersen, M. (2014) · Human Reproduction · doi:10.1093/humrep/deu133 · Cited by 65 · see citing works
“Balbach et al. (2013) investigated a population-based cohort of 2027 women and reported an inverse association between prolactin and type 2 diabetes risk; however, this was not retained after correcting for age, BMI and smoking status.”
BackgroundIslet cell plasticity and regeneration
Migliorini, A., Bader, E., & Lickert, H. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.01.010 · Cited by 59 · see citing works
“5 [86], but the”
The beneficial metabolic actions of prolactin
Macotela, Y., Ruíz‐Herrera, X., Vázquez-Carrillo, D. I., Ramírez‐Hernández, G., de la Escalera, G. M., & Clapp, C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1001703 · Cited by 60 · see citing works
“PRL stimulates the proliferation and survival of b-cells (53, 54), promotes glucose-induced insulin secretion (53), stimulates pancreas development during the perinatal stage (55), and is essential for b-cell expansion during pregnancy (18, 19, 56).”
BackgroundRomer, A. I., Singer, R. A., Sui, L., et al. (2019) · Diabetes · doi:10.2337/db19-0117 · Cited by 52 · see citing works
Gragnoli, C., Reeves, G. M., Reazer, J., & Postolache, T. T. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.50 · Cited by 41 · see citing works
Yang, H., Lin, J., Li, H., Liu, Z., Chen, X., & Chen, Q. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.571229 · Cited by 38 · see citing works
Goyvaerts, L., Lemaire, K., Arijs, I., Auffret, J., Granvik, M., Lommel, L. V., Binart, N., Veld, P. I. '., Schuit, F. C., & Schraenen, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121868 · Cited by 38 · see citing works
“Recently, it was shown that the beta cell mass of these Prlr-deficient mice is already impaired during embryogenesis [36].”
BackgroundSelf-citationKang, T., Jensen, P., Huang, H., Christensen, G. L., Billestrup, N., & Larsen, M. R. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra117.000217 · Cited by 34 · see citing works
Immunomodulatory role of decidual prolactin on the human fetal membranes and placenta
Flores‐Espinosa, P., Méndez, I. G., Irles, C., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1212736 · Cited by 28 · see citing works
Beta cell adaptation to pregnancy requires prolactin action on both beta and non-beta cells
Shrivastava, V., Lee, M., Lee, D., Pretorius, M., Radford, B. N., Makkar, G., & Huang, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-89745-9 · Cited by 24 · see citing works
Metformin in Gestational Diabetes Mellitus: To Use or Not to Use, That Is the Question
Tocci, V., Mirabelli, M., Salatino, A., Sicilia, L., Giuliano, S., Brunetti, F. S., CHIEFARI, E. D., Sarro, G. D., FOTI, D. P., & Brunetti, A. (2023) · Pharmaceuticals · doi:10.3390/ph16091318 · Cited by 31 · see citing works
“At this point, glucose homeostasis is ensured by maternal β -cell hypertrophy and hyperplasia, mainly supported by prolactin stimulation [17].”
BackgroundChhatriya, B., Mukherjee, M., Ray, S., et al. (2019) · BMC Cancer · doi:10.1186/s12885-019-6380-z · Cited by 23 · see citing works
Hyperprolactinemia induced by hCG leads to metabolic disturbances in female mice
Ratner, L. D., Stevens, G., Bonaventura, M. M., Lux-Lantos, V. A., POUTANEN, M. H., Calandra, R. S., Huhtaniemi, I. T., & Rulli, S. B. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0528 · Cited by 20 · see citing works
Metabolic targets of endocrine disrupting chemicals assessed by cord blood transcriptome profiling
Rémy, S., Govarts, E., Wens, B., et al. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.08.018 · Cited by 17 · see citing works
Serum Prolactin Levels and Mortality in Adults Without Prolactinoma: A Meta-Analysis
Papazoglou, Α. S., Leite, A. R., Moysidis, D. V., Anastasiou, V., Daios, S., Borges‐Canha, M., Γιαννόπουλος, Γ., Neves, J. S., Ziakas, A., & Giannakoulas, G. A. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae087 · Cited by 16 · see citing works
Prolactin effects on the pathogenesis of diabetes mellitus
Scairati, R., Auriemma, R. S., Vecchio, G. D., Meglio, S. D., Pivonello, R., & Colao, A. (2024) · European Journal of Clinical Investigation · doi:10.1111/eci.14190 · Cited by 14 · see citing works
Metabolic pathways in the periphery and brain: Contribution to mental disorders?
Nagalski, A., Koziński, K., & Wisniewska, M. B. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.09.012 · Cited by 14 · see citing works
Endocrinology of Fetal Development
Dattani, M., & Gevers, E. F. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00022-8 · Cited by 13 · see citing works
New insights into human prolactin pathophysiology: genomics and beyond
Chang, S., & Copperman, A. B. (2019) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000545 · Cited by 12 · see citing works
Harreiter, J., Vila, G., Leitner, K., Wattar, L., Leutner, M., Worda, C., Bancher‐Todesca, D., & Kautzky‐Willer, A. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.11.035 · Cited by 11 · see citing works
Fetal and Neonatal Endocrinology
Gevers, E. F., Fisher, D. A., & Dattani, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00145-1 · Cited by 11 · see citing works
Altered Pancreatic Growth and Insulin Secretion in WSB/EiJ Mice
Ho, M. M., Hu, X., Karunakaran, S., Johnson, J. D., & Clee, S. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088352 · Cited by 10 · see citing works
“Alterations, for example, in Wnt signaling can lead to markedly increased pancreatic weights when normalized to body weight [27], whereas defective prolactin signaling may also be a mechanism of reduced pancreatic growth affecting both acinar and exocrine tissue [29].”
BackgroundProlactin and pregnancy in mice and humans
Binart, N. (2016) · Annales d Endocrinologie · doi:10.1016/j.ando.2016.04.008 · Cited by 10 · see citing works
Self-citationBinart, N. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804169-7.00005-2 · Cited by 9 · see citing works
Self-citationRisk Assessment of Diabetes Mellitus During and After Pregnancy in Women With Prolactinomas
Scairati, R., Auriemma, R. S., Meglio, S. D., Vecchio, G. D., Pirchio, R., Graziadio, C., Pivonello, C., Pivonello, R., & Colao, A. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae289 · Cited by 8 · see citing works
Barbieri, R. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00010-x · Cited by 7 · see citing works
Paoli, M. D., Shah, D. N., Zakharia, A., Patel, Z., Patel, Z., Pakhi, P., & Werstuck, G. H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031816 · Cited by 7 · see citing works
“It should also be noted that prolactin is involved in the upregulation of pancreatic beta cell mass, stimulating pancreatic beta cell replication in pancreatic islets as well as insulinoma cells [37–39].”
BackgroundParagliola, R. M., Binart, N., & Salvatori, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99899-4.00025-1 · Cited by 6 · see citing works
Self-citationCell size regulates human endoderm specification through actomyosin-dependent AMOT-YAP signaling
Jiang, L., Yan, C., Yi, Y., et al. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.07.001 · Cited by 3 · see citing works
Katugampola, H., Gevers, E. F., & Dattani, M. (2019) · Wiley eBooks · doi:10.1002/9781119152712.ch3 · Cited by 2 · see citing works
Soni, A., Satyanarayana, P., & Yadav, B. (2024) · International Journal of Health Sciences and Research · doi:10.52403/ijhsr.20240241 · Cited by 1 · see citing works
Vázquez-Carrillo, D. I., Ocampo-Ruiz, A. L., Baez, A., Ramírez‐Hernández, G., Adán‐Castro, E., García-Rodrigo, J. F., Dena-Beltrán, J. L., Ríos, E. A. D. L., Sánchez-Martínez, M. K., Ortiz, M. G., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0301496 · Cited by 1 · see citing works
Regulation of islet function and gene expression by prolactin during pregnancyPreprint
Shrivastava, V., Lee, M., Pretorius, M., Makkar, G., & Huang, C. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/830836
“Prlr) has abnormal βcell mass expansion both embryonically and during perinatal life (2).”
BackgroundJin, Y., Jarmasz, J. S., Sultana, S., Cordero-Monroy, L., Taylor, C. G., Zahradka, P. C., Kardami, E., & Cattini, P. A. (2024) · Journal of Molecular Endocrinology · doi:10.1530/jme-24-0026
- Authors
- Auffret, J., Freemark, M., Carré, N., Mathieu, Y., Tourrel-Cuzin, C., Lombès, M., Movassat, J., & Binart, N.
- Affiliations
- Université Paris-Sud (FR)
- Duke University (US)
- Centre National de la Recherche Scientifique (FR)
- Université Paris Diderot, Sorbonne Paris Cité, CNRS EAC 4413, Équipe Biologie et Pathologie du Pancréas Endocrine, Paris, France; and
- Corresponding author
- Binart, Nadine
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2013-11-15
- Volume
- 305
- Issue
- 10
- Pages
- E1309-E1318
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- PMC
- PMC3840213
- OpenAlex
- W2044428487
- Semantic Scholar
- 9d7ea861f6a02239430b125d460756ef9482bfb5
- Cited by
- 46
- References
- 48
- Citations by year
- 2024: 8 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 8 · 2018: 3 · 2017: 2 · 2016: 8 · 2015: 4 · 2014: 4
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-09-BLAN-0246)
- Institut National de la Santé et de la Recherche Médicale
- Université Paris-Sud
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- prolactin signaling, prolactin receptor, pancreatic beta-cell development, beta-cell proliferation, perinatal period, mTOR signaling, insulin-like growth factor II, placental lactogen, type 2 diabetes, Goto-Kakizaki rats, embryonic pancreas
- MeSH terms
- Animals, Animals, Newborn, Cell Differentiation, Cells, Cultured, Embryo, Mammalian, Female, Pancreas, Pregnancy, Prolactin, Receptors, Prolactin, Signal Transduction, Rats, Wistar, Mice, Knockout, Insulin-Secreting Cells, Mice, Rats
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