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Cited by 36Pancreatic function and diabetesDiabetes Management and ResearchMetabolism, Diabetes, and Cancer

Effect of sequential infusions of glucagon and epinephrine on glucose turnover in the dog.

Saccà, L, Sherwin, R, Felig, P·1978·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.1978.235.3.e287
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Abstract

Conscious dogs were infused with 1) glucagon (3 ng/kg.min) alone for 120 min followed by glucagon plus epinephrine (0.1 microgram/kg.min) for 60 min and 2) epinephrine alone (150 min) followed by epinephrine plus glucagon for 90 min. Glucagon alone caused a 10--15 mg/dl rise in plasma glucose and a 45% increase in glucose production that returned to baseline by 75--120 min. After addition of epinephrine, glucose production rose again by 80%. Infusion of epinephrine alone resulted in unchanged plasma glucagon levels, a 60--70 mg/dl rise in plasma glucose, and an 80--100% rise in glucose production that returned to baseline by 60--120 min. When glucagon was added, glucose output promptly rose again by 85%. When glucagon was infused alone, there was a rise in glucose uptake, whereas, with epinephrine, glucose uptake failed to rise and glucose clearance fell by 35--50%. We conclude that 1) hepatic refractoriness to persistent elevations of glucagon or epinephrine is specific for the hormone infused; 2) epinephrine stimulates glucose production in the conscious dog in the absence of a rise in plasma glucagon; 3) the hyperglycemic response to glucagon or epinephrine is determined in part by accompanying changes in glucose utilization.

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Registry

Crossref · 10.1152/ajpendo.1978.235.3.e287

Cites

15 of 15 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Epinephrine inhibits insulin secretion.

    “Several studies have documented that epinephrine inhibits insulin secretion (1–5)”

    From Epinephrine-induced insulin resistance in man (1980) · cites this paper as [1]

  • An in vivo effect of epinephrine on peripheral glucose metabolism independent of changes in plasma insulin levels has not been conclusively documented.

    “an in vivo effect of epinephrine on peripheral glucose metabolism independent of changes in plasma insulin levels has not been conclusively documnented.”

    From Epinephrine-induced insulin resistance in man (1980) · cites this paper as [1]

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Related

Authors
Saccà, L., Sherwin, R., & Felig, P.
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
1978-09-01
Volume
235
Issue
3
Pages
E287
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.1978.235.3.e287
OpenAlex
W2461016652
Cited by
36
References
15
Citations by year
2018: 1
FWCI
7.28
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
glucagon, epinephrine, glucose turnover, hepatic glucose production, hepatic glucose uptake, glucose clearance, hyperglycemia, plasma glucose, dogs
MeSH terms
Animals, Dogs, Epinephrine, Glucagon, Glucose, Infusions, Parenteral, Liver, Male

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