Relationship between plasma osmolality and plasma vasopressin in human subjects.
Abstract
The relationship between plasma osmolality (pOsm) and plasma vasopressin (pAVP) was studied in 13 human subjects during dehydration. The fit of linear, log-linear, parabolic, and exponential models was tested. For all of the data, the nonlinear models had the best fit. However, when individual differences in either gain or threshold were allowed for, the linear models were better than log-linear models. Finally, analyses were made with individual data points. Linear models had the best fit in half of the subjects, whereas for the others the parabolic model gave the best fit. For those subjects investigated in the low range of the osmoregulatory curve, a linear relationship was found, whereas, for those having the most pronounced increase in pOsm, the most significant improvement was found with the parabolic model. This finding indicates that the relationship is not stable during dehydration in the whole range and that hypovolemia probably can influence the secretion rate and/or metabolic clearance rate and thereby the relationship.
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Antidiuretic hormone concentration is defined depending on serum osmolality, which value can be considered as function of plasma sodium concentration and levels of glucose and urea in blood.
“Antidiuretic hormone concentration is defined depending on serum osmolality (Hammer et al., 1980), which value can be considered as function of plasma sodium concentration and levels of glucose and urea in blood (Dorwart and Chalmers, 1975; Bhagat et al., 1984).”
From Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease (2021) · cites this paper as Hammer et al., 1980
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- Authors
- Hammer, M., Ladefoged, J., & Olgaard, K.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1980-04-01
- Volume
- 238
- Issue
- 4
- Pages
- E313-E317
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2406653149
- Cited by
- 52
- References
- 7
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 1 · 2015: 2 · 2014: 1 · 2012: 1
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- plasma osmolality, plasma vasopressin, dehydration, osmoregulation, vasopressin release, hypovolemia, nonlinear models, individual differences, metabolic clearance rate
- MeSH terms
- Adolescent, Adult, Dehydration, Female, Humans, Male, Middle Aged, Osmolar Concentration, Plasma, Radioimmunoassay, Sodium, Vasopressins
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