Cerebrospinal-fluid vasopressin in neurological and psychiatric-disorders
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Vasopressin was determined in CSF and plasma of 243 patients with different neurological and psychiatric disorders, including control patients. CSF vasopressin was significantly higher in patients with high pressure hydrocephalus, intracranial tumour, benign intracranial hypertension, intracranial haemorrhage, ischaemic stroke, and craniocerebral trauma. In patients with primary degenerative dementia, CSF vasopressin was lower than in control patients. Among patients with psychiatric disorders, CSF vasopressin was increased in manic patients, while in patients with depression CSF concentration of this hormone did not differ from that found in controls. However, an increase in CSF vasopressin level was found in patients recovering from a depression. The clinical significance of changes in CSF vasopressin concentrations in groups of patients with neurological and psychiatric disorders is still unknown.
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In the MDD subgroup, sensitivity analysis revealed that overall plasma level of ADH were affected by inclusion of Sorensen et al. (1985).
“In the MDD subgroup, sensitivity analysis revealed that overall plasma level of ADH were affected by inclusion of Sorensen et al. (1985).”
From Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis (2016) · cites this paper as Sorensen et al. (1985)
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- Authors
- Sorensen, P. S., Gjerris, A., & Hammer, M.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1985-01-01
- Volume
- 48
- Issue
- 1
- Pages
- 50-57
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC1028182
- OpenAlex
- W2048921697
- Cited by
- 103
- References
- 46
- Citations by year
- 2026: 2 · 2024: 2 · 2021: 2 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 1 · 2014: 5 · 2013: 2 · 2012: 2
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- vasopressin, cerebrospinal fluid, plasma vasopressin, intracranial tumors, idiopathic intracranial hypertension, intracranial hemorrhage, ischemic stroke, traumatic brain injury, degenerative dementia, mania, depression, recovery from depression
- MeSH terms
- Adult, Aged, Arginine Vasopressin, Basal Ganglia Diseases, Mental Disorders, Bipolar Disorder, Brain Diseases, Brain Neoplasms, Cerebral Hemorrhage, Cerebral Infarction, Dementia, Depressive Disorder, Female, Humans, Hydrocephalus, Hydrocephalus, Normal Pressure, Intracranial Pressure, Male, Middle Aged, Multiple Sclerosis, Pseudotumor Cerebri, Schizophrenia
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