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Cited by 134Adrenal Hormones and DisordersDiabetes Management and ResearchPancreatic function and diabetes

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Contribution of cortisol to glucose counterregulation in humans

De Feo, P., Perriello, G., Torlone, E., Ventura, M. M., Fanelli, C., Santeusanio, F., Brunetti, P., Gerich, J. E., Bolli, G. B.·1989·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.1989.257.1.e35
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Abstract

To test the hypothesis that cortisol secretion plays a counterregulatory role in hypoglycemia in humans, four studies were performed in eight normal subjects. In all studies, insulin (15 mU.m-2.min-1) was infused subcutaneously (plasma insulin 27 +/- 1 microU/ml). In study 1, plasma glucose concentration and glucose fluxes [( 3-3H]glucose), substrate, and counterregulatory hormone concentrations were simply monitored, and plasma glucose decreased from 89 +/- 2 to 52 +/- 2 mg/dl for 12 h. In study 2, (pituitary-adrenal-pancreatic clamp), insulin and counterregulatory hormone secretion (except for catecholamines) was prevented by somatostatin (0.5 mg/h, iv) and metyrapone (0.5 g/4 h, per os), and glucagon, cortisol, and growth hormone were infused to reproduce the concentrations of study 1. In study 3 (lack of cortisol increase), the pituitary-adrenal-pancreatic clamp was performed with maintenance of plasma cortisol at basal levels, and glucose was infused, whenever needed, to reproduce plasma glucose concentration of study 2. Study 4 was identical to study 3, but exogenous glucose was not infused. Isolated lack of cortisol increase caused a approximately 22% decrease in hepatic glucose production (P less than 0.01) and a approximately 15% increase in peripheral glucose utilization (P less than 0.01), which resulted in greater hypoglycemia (37 +/- 2 vs. 52 +/- 2 mg/dl, P less than 0.01) despite compensatory increases in plasma epinephrine. Lack of cortisol response also reduce…

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Research works printed but not linked: 12

  1. 1984, J. Med., 310, 1706
  2. 1986, MetaboZism, 35, 404
  3. 1963, Horm. Res., 19, 445
  4. 10.2337/diabetes.35.5.563 · DOI
  5. J. BioZ. Chem., 235, 2595
  6. GERICH J., J., 1979, Metab. Gastrointest. Physiol. 5), E380
  7. GERICH J., M., 1981, MD: University Park, 419
  8. LECAVALIER L., 1988, Diabetes, 37, 73A
  9. LONG C., 1960, Wolstenholm and M. Conner. London: Churchill, 121
  10. LOWRY O., 1972, New York: Academic, 148
  11. MATTINGLY D, 1964, J. CZin. Pathol., 15, 374
  12. PEAKE G, 1974, Jaffe and H. Behrman. New York: Academic, 103

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Metadata

Authors
De Feo, P., Perriello, G., Torlone, E., Ventura, M. M., Fanelli, C., Santeusanio, F., Brunetti, P., Gerich, J. E., & Bolli, G. B.
Affiliations
  • Istituto di Patologia Medica, Universita di Perugia, Italy.
  • University of Perugia (IT)
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
1989-07-01
Volume
257
Issue
1
Pages
E35-E42
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.1989.257.1.e35
OpenAlex
W1952942405
Cited by
134
References
21
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 1 · 2014: 5 · 2013: 9 · 2012: 1
FWCI
1.46
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (DK-20411)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords
cortisol, glucose counterregulation, hypoglycemia, hepatic glucose production, peripheral glucose utilization, lipolysis, epinephrine, somatostatin, metyrapone, glucagon, growth hormone, free fatty acids, beta-hydroxybutyrate, glycerol, insulin-induced hypoglycemia
MeSH terms
Adult, Alanine, Blood Glucose, C-Peptide, Epinephrine, Fatty Acids, Nonesterified, Female, Glucagon, Glycerol, Humans, Hydrocortisone, Hydroxybutyrates, Insulin, Kinetics, Lactates, Male, Portal Vein, Growth Hormone, Lactic Acid, 3-Hydroxybutyric Acid

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