Energy expenditure during normo- and overfeeding in peripubertal children of lean and obese Pima Indians
Abstract
We investigated the hypothesis that peripubertal children born to obese parents have a lower 24-h energy expenditure during "weight maintenance" and/or in response to overfeeding when compared with children born to normal-weight parents. Sixteen Southwestern American Indians (12.4 +/- 1.4 yr, 55.5 +/- 14.1 kg, 30 +/- 8% body fat), eight offspring from obese parents [body mass index (BMI) = 40 +/- 6 kg/m2], and eight offspring from thin parents (BMI = 24 +/- 3 kg/m2) were admitted for 8 days to our metabolic ward. The 24-h energy expenditure was measured under eucaloric conditions and on the 3rd day of progressive overfeeding of a mixed diet, i.e., 150, 200, and 200% of weight maintenance on day 1, 2, and 3 of overfeeding. At base line, offspring of obese parents were heavier (64 +/- 15 vs. 47 +/- 6 kg, P less than 0.05) and tended to be fatter (34 +/- 8 vs. 26 +/- 9% body fat, P = 0.07), with a higher absolute fat mass (22 +/- 9 vs. 13 +/- 4 kg body fat, P less than 0.05) when compared with offspring of thin parents. During both normo- and over-feeding, the larger part of the variance in 24-h energy expenditure in the conditions of a respiratory chamber was accounted for by differences in fat-free body mass (54 and 68%, respectively), whereas differences in the level of spontaneous physical activity accounted for another 19 and 21%.(ABSTRACT TRUNCATED AT 250 WORDS)
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Both controlled studies suggest similar metabolic flexibility to carbohydrate-enriched diets in obese and lean individuals.
“Both studies suggest similar metabolic flexibility to carbohydrate- enriched diets in obese and lean individuals.”
From Metabolic flexibility and insulin resistance (2008) · cites this paper as [12]
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Metabolic flexibility and insulin resistance
Galgani, J. E., Moro, C., & Ravussin, E. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90558.2008 · Cited by 532 · see citing works
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- Authors
- Freymond, D., Larson, K., Bogardus, C., & Ravussin, E.
- Affiliations
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Clinical Diabetes and Nutrition Section, National Institute ofDiabetes and Digestive and Kidney Diseases, Phoenix, Arizona 85016.
- ORCID
- Bogardus, C.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 1989-11-01
- Volume
- 257
- Issue
- 5
- Pages
- E647-E653
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2401335508
- Cited by
- 16
- References
- 14
- Citations by year
- 2025: 1 · 2020: 1 · 2016: 1 · 2012: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- energy expenditure, overfeeding, peripubertal children, Pima Indians, parental obesity, fat-free mass, spontaneous physical activity, fat mass, weight maintenance, respiratory chamber
- MeSH terms
- Adolescent, Catecholamines, Child, Eating, Energy Metabolism, Humans, Indians, North American, Nutritional Physiological Phenomena, Obesity, Puberty, Reference Values
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