Cited by 194Growth Hormone and Insulin-like Growth FactorsRegulation of Appetite and ObesityPancreatic function and diabetes

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Effects of a growth hormone pulse on total and forearm substrate fluxes in humans

Moller, N., Jorgensen, J. O., Schmitz, O., Moller, J., Christiansen, J., Alberti, K. G., Orskov, H.·1990·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.1990.258.1.e86

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Abstract

Under physiological circumstances growth hormone (GH) is secreted in bursts after the onset of sleep and a few hours postprandially. Because most relevant studies have employed constant or repeated infusion of high doses of GH, the possible metabolic effects of such bursts are largely unknown. We have studied seven healthy, male subjects for 7 h after an intravenous bolus of 1) 140 micrograms GH and 2) saline. When injected, serum GH rose to a peak of 21 +/- 3 micrograms/l 10 min after injection. GH caused 1) a rapid, sustained 55% decrease in forearm glucose uptake (P less than 0.05) followed by increases toward control values, 2) a delayed 5 mg/100 ml decrease in plasma glucose (P less than 0.05), and 3) significant 60-250% increases (P less than 0.05) in all measured lipid intermediates (nonesterified fatty acids, 3-hydroxybutyrate, and glycerol) 120-160 min after administration followed by decreases to below control values (P less than 0.05). GH did not influence circulating levels of insulin, C-peptide, glucagon, or insulin-like growth factor I (IGF-I), or isotopically determined glucose turnover. Physiological bursts of GH secretion appear to have acute insulin antagonistic effects with maximal effect on lipolysis after 2 h. These effects are reversed after 4 h. Therefore, GH could play a key role in regulation of diurnal rhythms of substrate levels and fuel utilization in humans.

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Authors: Moller, N., Jorgensen, J. O., Schmitz, O., Moller, J., Christiansen, J., Alberti, K. G., & Orskov, H.
Affiliations: Second University Clinic of Internal Medicine, Aarhus, Denmark.
Aarhus University (DK)
ORCID: Christiansen, J.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 1990-01-01
Volume: 258
Issue: 1
Pages: E86-E91
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.1990.258.1.e86
OpenAlex: W1870120585
Semantic Scholar: 7c789df8e99e99d123e8060df65caa9dfebbf2b1
Cited by: 194
References: 21
Citations by year: 2026: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 3 · 2013: 6 · 2012: 7
FWCI: 5.66
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords: growth hormone, glucose uptake, lipolysis, free fatty acids, beta-hydroxybutyrate, glycerol, insulin antagonism, plasma glucose, diurnal cycle, substrate utilization, insulin-like growth factor I
MeSH terms: Adult, Analysis of Variance, Blood Glucose, C-Peptide, Fatty Acids, Nonesterified, Forearm, Glucagon, Glycerol, Humans, Hydroxybutyrates, Injections, Intravenous, Insulin, Kinetics, Male, Regional Blood Flow, Growth Hormone, Time Factors, 3-Hydroxybutyric Acid

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Effects of a growth hormone pulse on total and forearm substrate fluxes in humans

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