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Cited by 194Growth Hormone and Insulin-like Growth FactorsRegulation of Appetite and ObesityPancreatic function and diabetes

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Effects of a growth hormone pulse on total and forearm substrate fluxes in humans

Moller, N., Jorgensen, J. O., Schmitz, O., Moller, J., Christiansen, J., Alberti, K. G., Orskov, H.·1990·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.1990.258.1.e86
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Abstract

Under physiological circumstances growth hormone (GH) is secreted in bursts after the onset of sleep and a few hours postprandially. Because most relevant studies have employed constant or repeated infusion of high doses of GH, the possible metabolic effects of such bursts are largely unknown. We have studied seven healthy, male subjects for 7 h after an intravenous bolus of 1) 140 micrograms GH and 2) saline. When injected, serum GH rose to a peak of 21 +/- 3 micrograms/l 10 min after injection. GH caused 1) a rapid, sustained 55% decrease in forearm glucose uptake (P less than 0.05) followed by increases toward control values, 2) a delayed 5 mg/100 ml decrease in plasma glucose (P less than 0.05), and 3) significant 60-250% increases (P less than 0.05) in all measured lipid intermediates (nonesterified fatty acids, 3-hydroxybutyrate, and glycerol) 120-160 min after administration followed by decreases to below control values (P less than 0.05). GH did not influence circulating levels of insulin, C-peptide, glucagon, or insulin-like growth factor I (IGF-I), or isotopically determined glucose turnover. Physiological bursts of GH secretion appear to have acute insulin antagonistic effects with maximal effect on lipolysis after 2 h. These effects are reversed after 4 h. Therefore, GH could play a key role in regulation of diurnal rhythms of substrate levels and fuel utilization in humans.

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Crossref · 10.1152/ajpendo.1990.258.1.e86

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21 of 21 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 7

  1. DAGENAIS G. R., 1976, J. Clin. Invest., 421
  2. WALESKY R. S., 1979, Raven, 143
  3. 1986, Metab. 13), E686
  4. HANSEN I., E., 1986, Metab. 13), E269
  5. LLOYD B., J., 1978, CZin. Chem., 24, 1724
  6. SIREK A., M, Am. J. Physiol., 237
  7. VAITKUS P., A., Am. J. Physiol., 246

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Metadata

Authors
Moller, N., Jorgensen, J. O., Schmitz, O., Moller, J., Christiansen, J., Alberti, K. G., & Orskov, H.
Affiliations
  • Second University Clinic of Internal Medicine, Aarhus, Denmark.
  • Aarhus University (DK)
ORCID
Christiansen, J.
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
1990-01-01
Volume
258
Issue
1
Pages
E86-E91
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.1990.258.1.e86
OpenAlex
W1870120585
Semantic Scholar
7c789df8e99e99d123e8060df65caa9dfebbf2b1
Cited by
194
References
21
Citations by year
2026: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 3 · 2013: 6 · 2012: 7
FWCI
5.66
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords
growth hormone, glucose uptake, lipolysis, free fatty acids, beta-hydroxybutyrate, glycerol, insulin antagonism, plasma glucose, diurnal cycle, substrate utilization, insulin-like growth factor I
MeSH terms
Adult, Analysis of Variance, Blood Glucose, C-Peptide, Fatty Acids, Nonesterified, Forearm, Glucagon, Glycerol, Humans, Hydroxybutyrates, Injections, Intravenous, Insulin, Kinetics, Male, Regional Blood Flow, Growth Hormone, Time Factors, 3-Hydroxybutyric Acid

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