Sympathetic Activation in Chronic Renal Failure
Abstract
The potential involvement of sympathetic overactivity has been neglected in this population despite accumulating experimental and clinical evidence suggesting a crucial role of sympathetic activation for both progression of renal failure and the high rate of cardiovascular events in patients with chronic kidney disease. The contribution of sympathetic neural mechanisms to the occurrence of cardiac arrhythmias, the development of hypertension, and the progression of heart failure are well established; however, the exact mechanisms contributing to heightened sympathetic tone in patients with chronic kidney disease are unclear. This review analyses potential mechanisms underlying sympathetic activation in chronic kidney disease, the range of adverse consequences associated with this activation, and potential therapeutic implications resulting from this relationship.
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Sympathetic nervous system activation is present in patients with chronic kidney disease.
“Sympathetic nervous system activation is present in patients with chronic kidney disease, intimated first with the finding of elevated plasma norepinephrine concentrations100–101, then more definitively with demonstration of whole-body norepinephrine spillover measurements and increased sympathetic nerve firing recorded with clinical microneurography48–51,102.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [102]
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Role of the sympathetic nervous system in regulation of the sodium glucose cotransporter 2
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Self-citationIndoxyl Sulfate: A Novel Cardiovascular Risk Factor in Chronic Kidney Disease
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Self-citationRenal denervation: a potential new treatment modality for polycystic ovary syndrome?
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International Expert Consensus Statement
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Self-citationRenal denervation prevents long-term sequelae of ischemic renal injury
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Self-citationFGF23-Mediated Activation of Local RAAS Promotes Cardiac Hypertrophy and Fibrosis
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The Role of Renal Denervation in the Treatment of Heart Failure
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Improvement of albuminuria after renal denervation
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Renal Denervation and Hypertension
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Self-citationActivation of afferent renal nerves modulates RVLM-projecting PVN neurons
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- Authors
- Schlaich, M. P., Socratous, F., Hennebry, S., Eikelis, N., Lambert, E. A., Straznicky, N., Esler, M. D., & Lambert, G. W.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- Corresponding author
- Schlaich, Markus P.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2009-05
- Volume
- 20
- Issue
- 5
- Pages
- 933-939
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2150333966
- Cited by
- 408
- References
- 77
- Citations by year
- 2025: 12 · 2024: 12 · 2023: 25 · 2022: 14 · 2021: 17 · 2020: 20 · 2019: 25 · 2018: 17 · 2017: 36 · 2016: 34 · 2015: 21 · 2014: 32 · 2013: 44 · 2012: 35
- FWCI
- 17.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Society of Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- sympathetic activation, chronic kidney disease, sympathetic hyperactivity, cardiovascular events, cardiac arrhythmias, hypertension, heart failure, renal failure progression, therapeutic target
- MeSH terms
- Animals, Cardiovascular Diseases, Catecholamines, Clonidine, Debrisoquin, Disease Models, Animal, Efferent Pathways, Humans, Hypertension, Kidney, Kidney Failure, Chronic, Monoamine Oxidase, Nerve Fibers, Nitric Oxide, Norepinephrine, Sympathetic Nervous System
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