Cited by 408Chronic Kidney Disease and DiabetesBlood Pressure and Hypertension StudiesDialysis and Renal Disease Management

Sympathetic Activation in Chronic Renal Failure

Schlaich, Markus P., Socratous, Flora, Hennebry, Sarah, Eikelis, Nina, Lambert, Elisabeth A., Straznicky, Nora, Esler, Murray D., Lambert, Gavin W.·2009·Journal of the American Society of Nephrology

Abstract

The potential involvement of sympathetic overactivity has been neglected in this population despite accumulating experimental and clinical evidence suggesting a crucial role of sympathetic activation for both progression of renal failure and the high rate of cardiovascular events in patients with chronic kidney disease. The contribution of sympathetic neural mechanisms to the occurrence of cardiac arrhythmias, the development of hypertension, and the progression of heart failure are well established; however, the exact mechanisms contributing to heightened sympathetic tone in patients with chronic kidney disease are unclear. This review analyses potential mechanisms underlying sympathetic activation in chronic kidney disease, the range of adverse consequences associated with this activation, and potential therapeutic implications resulting from this relationship.

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Registry

Crossref · 10.1681/asn.2008040402

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77 of 77 references verified0 citation errors · 0 not checkable

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  • Sympathetic nervous system activation is present in patients with chronic kidney disease.

    “Sympathetic nervous system activation is present in patients with chronic kidney disease, intimated first with the finding of elevated plasma norepinephrine concentrations100–101, then more definitively with demonstration of whole-body norepinephrine spillover measurements and increased sympathetic nerve firing recorded with clinical microneurography48–51,102.”

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Authors
Schlaich, M. P., Socratous, F., Hennebry, S., Eikelis, N., Lambert, E. A., Straznicky, N., Esler, M. D., & Lambert, G. W.
Affiliations
Baker Heart and Diabetes Institute (AU)
Corresponding author
Schlaich, Markus P.
Venue
Journal of the American Society of Nephrology
Published
2009-05
Volume
20
Issue
5
Pages
933-939
ISSN
1046-6673 (ISSN-L)
OpenAlex
W2150333966
Cited by
408
References
77
Citations by year
2025: 12 · 2024: 12 · 2023: 25 · 2022: 14 · 2021: 17 · 2020: 20 · 2019: 25 · 2018: 17 · 2017: 36 · 2016: 34 · 2015: 21 · 2014: 32 · 2013: 44 · 2012: 35
FWCI
17.16
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the American Society of Nephrology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Keywords
sympathetic activation, chronic kidney disease, sympathetic hyperactivity, cardiovascular events, cardiac arrhythmias, hypertension, heart failure, renal failure progression, therapeutic target
MeSH terms
Animals, Cardiovascular Diseases, Catecholamines, Clonidine, Debrisoquin, Disease Models, Animal, Efferent Pathways, Humans, Hypertension, Kidney, Kidney Failure, Chronic, Monoamine Oxidase, Nerve Fibers, Nitric Oxide, Norepinephrine, Sympathetic Nervous System

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